Hello all, I would really like to try GHK-Cu but I've read comment after comment about how awful the pain is using it. I have also read that adding either KPV or BPC-157 can help with the sting. I do not want to try either KLOW or GLOW at this time so I would like thoughts and advice. If I were to mix the GHK-Cu with either, now much BAC water would you use? Thanks for the guidance.
GHK-Cu Fears
- Thread starter HistLady
- Start date
Diamondd817
GLP-1 Apprentice
For starters you can reconstitute a 50mg vial into a 10ml sterile vial with 8ml of BAC and a 2.5mg dose would be 40 units.
Whichever concentration you decide on, you should inject it in your glutes (upper outer right or left quadrant). I tried everywhere on my body and the glutes are pain free and site reaction free.
Whichever concentration you decide on, you should inject it in your glutes (upper outer right or left quadrant). I tried everywhere on my body and the glutes are pain free and site reaction free.
FarmgirlRebel
GLP-1 Enthusiast
I no longer even feel it...you can dilute the vial or do what I do and just add extra bac water to the syringe after you draw the GHKcu. I have a designated bac vial just for this...but at this point, I don't even feel it when I do it straight w/o dilution.
The after burn can be real for some, but I never thought it was bad enough to discontinue. Your mileage may vary.
The after burn can be real for some, but I never thought it was bad enough to discontinue. Your mileage may vary.
sheilarae74
GLP-1 Enthusiast
The sting is really not that bad if you dilute it with enough bac water. I pin in the fattest part of my ass and it doesn't hurt at all.
Honestly, even if it sucks for you, it’ll suck for 24 hours but it’s not horrible. Maybe a sleepless night and plenty of time to question your life choices. But you might want to just try a small pin without anything extra to see how you react to it. You may be one of the very blessed who doesn’t feel any burn or post-injection pain. (And don’t declare victory immediately. For me, the pain starts after a few hours.)
My recommendations in order for mitigating pain are:
1) First try the extra BAC method.
2) Add GHK-Basic. Anywhere from a 1:1 ratio or a 5:1 ratio (Cu:basic) will usually take care of the issue.
3) Add some epi/lido. The lido will only help with any immediate injection site burn or pain you get but the epi will help mitigate the histamine response that causes most of the issue.
I rotate using BPC, KPV, and TB4 anyway, but none were ever sufficient to mitigate the Cu problems. Some people swear by it. One thing I’ve learned through reading dozens of discussions about this is that everyone reacts differently. My recommendations above are listed in order of ease and cost effectiveness.
For me, #2 is the most effective and the only thing I do at this point. (No extra BAC. No more epi/lido anymore.) GHK-Basic can sometimes be hard to come by but it’s pretty readily available at the moment. And a little bit goes a long way.
Good luck!
My recommendations in order for mitigating pain are:
1) First try the extra BAC method.
2) Add GHK-Basic. Anywhere from a 1:1 ratio or a 5:1 ratio (Cu:basic) will usually take care of the issue.
3) Add some epi/lido. The lido will only help with any immediate injection site burn or pain you get but the epi will help mitigate the histamine response that causes most of the issue.
I rotate using BPC, KPV, and TB4 anyway, but none were ever sufficient to mitigate the Cu problems. Some people swear by it. One thing I’ve learned through reading dozens of discussions about this is that everyone reacts differently. My recommendations above are listed in order of ease and cost effectiveness.
For me, #2 is the most effective and the only thing I do at this point. (No extra BAC. No more epi/lido anymore.) GHK-Basic can sometimes be hard to come by but it’s pretty readily available at the moment. And a little bit goes a long way.
Good luck!
leeann82
GLP-1 Apprentice
It sure can be a nasty one if you dont add enough bac. I used 10ml back in 70mg ghk. Doesn't hurt anymore...which is also think just got better with time...but it does still leave a bit of a lump for a couple days
RascalRaccoon
GLP-1 Enthusiast
Seconding what's already been said, you can also let it come to room temperature after drawing before pinning to help with the sting. That being said you may have no reaction at all like my partner. Everyone is different.
Personally I use an 8mm needle in my glute (upper outer quadrant sub-Q) and that has reduced the sting a lot (and dilute 7ml BAC water to 50mg GHK-CU). Most days I feel nothing at all, some days I may have a bit of a dull sting a couple hours later, but nothing at the time of injection. I dose 2mg/daily.
Personally I use an 8mm needle in my glute (upper outer quadrant sub-Q) and that has reduced the sting a lot (and dilute 7ml BAC water to 50mg GHK-CU). Most days I feel nothing at all, some days I may have a bit of a dull sting a couple hours later, but nothing at the time of injection. I dose 2mg/daily.
Thank you for the detailed reply. I am not sure I completely understand number 2--sorry if I am being obtuse.
HereKittyKitty
GLP-1 Enthusiast
I did my first couple of vials with a lot of bac water. I think I used 5-6ml reconned in a 10ml vial.
This current vial, I reconned one 50mg Cu with one 50mg Basic (no Cu), using 3 ml or so of bac, and it's nothing.
I also pin in the side of my butt. Alternating sides and in the same general area but do try to move the injection site around a bit. Fortunately, there's plenty of ass to choose from. 🤣🤣
I've noticed a HUGE improvement in my heels and my cuticles plus my complexion is more even and smooth.
This current vial, I reconned one 50mg Cu with one 50mg Basic (no Cu), using 3 ml or so of bac, and it's nothing.
I also pin in the side of my butt. Alternating sides and in the same general area but do try to move the injection site around a bit. Fortunately, there's plenty of ass to choose from. 🤣🤣
I've noticed a HUGE improvement in my heels and my cuticles plus my complexion is more even and smooth.
GHK-Basic is the same GHK tripeptide without the Cu bound to it. There are a few threads here and also on Peppy’s about it. When you blend some in with your GHK-Cu, it usually completely mitigates the pain or burn people feel with GHK-Cu. I think the theory is that the GHK will bind with some of the free copper.
I normally shoot for 1.5-2 mg/day of GHK-Cu. So, on the low end (just for an example), you can start with as little as 0.3 mg/day of basic to get the 5:1 ratio (5 times as much GHK-Cu as GHK-basic). If that doesn’t mitigate the issue, then you add more. Most people seem to do fine with a 3:1 or 5:1 ratio but some prefer to do equal amounts (1:1).
ETA - just to be clear, I do blend them into the same vial after I decide what ratio I want. (I use sterile vials and filter but that’s another discussion.)
Also, as someone mentioned above, longer needles also helps to get below the MAST layer. I use 12mm. I’ve never gotten a knot or lump.
Last edited:
Thank you for the explanation! I really appreciate it and will look into it.
HereKittyKitty
GLP-1 Enthusiast
ThatNextGril
GLP-1 Enthusiast
I've been pinning 2mg of GHK-cu daily for about 10 weeks now. I do the extra bac method (I add 3ml to the GHK to recon, then add that and another 3ml to a larger 10ml vial, and then transfer to carts for my pen). Since I use a pen, I prefer not to let it get to room temp (that would mean getting it to room temp and fridge temp over and over about 30 times, which wouldn't be great) but just pin straight away. I have to go slowly and then massage the glute where I pinned a little. Some days I feel nothing, other days (like today!) I feel a little bit of annoying burn, but it's truly annoying more than painful. I also get the red welts a few times a week. I wish I had no reaction to it, as I don;t plan to stop taking it any time in the future, and might look to the epi addition eventually to see if that does help.
In the end, there are definitely ways to manage or mitigate the sting of GHK-cu, so it's really down to how much you want to commit to it and what you feel the benefits are worth.
In the end, there are definitely ways to manage or mitigate the sting of GHK-cu, so it's really down to how much you want to commit to it and what you feel the benefits are worth.
bk0004
GLP-1 Novice
🚫No Source Discussion🚫
It really wasn't bad for me. I was terrified but the stinging was mild and welts were small. Reaction got less over time. Now I don't even feel it at all!
I just have to get brave this week.
grandpa_is_healthier
GLP-1 Apprentice
I’ll pile on here 😅 started pinning GHK CU just a week ago and after tons of research I went with 5ml of bac to 50mg. I alternate butt cheeks, no sting but I definitely get those welts of course I’m not bothered by that since I don’t regularly look at my butt cheeks😉. After this vial is spent to plan to add KPV to it. Two peps in one pin.
You got this!!
You got this!!
domin8brix
GLP-1 Apprentice
So is it like localized injection site pain or systemic pain?
In the abdomen it results in localized injection site pain that stings for hours, leaves red welts, and ugly painful bruises that take 7-10 days to resolve. In the butt it still stings a little but in comparison it is not even worth mentioning.
Optimistic3
Recently Joined
🚫No Source Discussion🚫
For me I have found that my right side of my body stings, and gets itchy and red even in the glute. However all the fattier sections I pinch and pin on my left side work perfect, little massage to the area right after pinning and no issues at all. It’s weird but for me my left side can take it. Also I let it come to room temperature before using it too. I did 4ml bac to 50mg ghk-cu
Last edited:
minipepbeast
GLP-1 Apprentice
It's a histamine reaction from your mast cells. Take an allergy medicine an hour or so before pinning. No extra bac required.
randompersonrandom
GLP-1 Specialist
Interestingly enough, I no longer get considerable pain OR the bruising, and I've gone back to a regular concentration.
The pain was not and never was the kind of scary "OWWWW" pain at pinning. It was soreness twelve hours later. Mentioning it because it's not the kind of pain to be fearful of, more of a hassle.
The pain was not and never was the kind of scary "OWWWW" pain at pinning. It was soreness twelve hours later. Mentioning it because it's not the kind of pain to be fearful of, more of a hassle.
I took my first pin of Glow two days ago in my upper glute area. No problem. No sting.
Last night took the second in my inner thigh fat. One hour later the spice started. It hurt like a bitch and it still aches 24 hours later. Tonight I added more Bac to my syringe and went back to the glute area and also used a longer needle. Not quite and hour in but so far so good.
Last night took the second in my inner thigh fat. One hour later the spice started. It hurt like a bitch and it still aches 24 hours later. Tonight I added more Bac to my syringe and went back to the glute area and also used a longer needle. Not quite and hour in but so far so good.
How long of a needle? And thanks for the info.
I ordered some 1/2" from Amazon. It's a bit intimidating but was actually no big deal putting in a good fatty spot that I pinched up. And I can report this morning still no bite, sting, welt or ache!
rkbleddyn
GLP-1 Apprentice
Yeah, I get it. Same here. I just keep looking at mine and have yet to reconstitute it. I think the best idea I have seen is: Draw up your dose and then fill the rest of the syringe with BAC water to dilute it and inject slowly.
I use the smaller 30 unit syringes with the 5/16" needle when I can, for small doses like 500mcg or less. For the GHK cu I am likely to use the 100 unit syringe because then I can dilute it more, at least for a first attempt. The needle is 1/2" but not an issue. I like the 30 unit syringe for small doses because it's quicker to get more accuracy.
I use the smaller 30 unit syringes with the 5/16" needle when I can, for small doses like 500mcg or less. For the GHK cu I am likely to use the 100 unit syringe because then I can dilute it more, at least for a first attempt. The needle is 1/2" but not an issue. I like the 30 unit syringe for small doses because it's quicker to get more accuracy.
Last edited:
rkbleddyn
GLP-1 Apprentice
Funny how when you are searching online when you first learn about peptides, they are all blue, but I think GHK cu is the only one that is actually supposed to be blue 😎. I hope they are not putting any blue food coloring in my 99% pure peptides. So far, so good, no blue peptides until I reconstitute the GHK anyway.
Ruckus4519
GLP-1 Enthusiast
Really not that bad, prolly after using 8mL BAC and a longer needle. I think it was mostly psych during pinning
I will say the ISRs look concerning though.
I will say the ISRs look concerning though.
amosmylove
GLP-1 Enthusiast
I noticed a sting the first and second time I used it, but I didn't even pinpoint that it was from the ghkcu at the time. I haven't had any issues since and I don't and never have diluted it. I take 2.5mg in 5 units of bac water daily with zero pain or issues.
I usually draw it up in the same syringe as 10 units of Bpc157.
I wouldn't assume that it will be painful unless it lasts past several days of initial use.
I usually draw it up in the same syringe as 10 units of Bpc157.
I wouldn't assume that it will be painful unless it lasts past several days of initial use.
Last edited:
