Diamondd817
GLP-1 Apprentice
I just started. I got the Tesa/Imp 10/3mg Blend. I am taking 2/.6 mg dose in the am when I wake up. Too early to see results but I have my fingers crossed.
Any Tesamorelin users in here.
- Thread starter Whiynot20026
- Start date
Ticks
GLP-1 Apprentice
For those of you wondering about night or morning, especially with reta, here is the conclusion of my research.
1. IGF-1 output tracks GH pulse amplitude, and meal-induced insulin blunts that pulse at the pituitary — so protecting the fasted state outranks protecting circadian timing.
2. IGF-1 is timing-insensitive anyway (long half-life, integrates GH exposure across the day, builds to steady state over ~2 weeks), so the “lost nocturnal synergy” of a morning shot carries essentially no cost. That’s what makes the trade clearly favor morning fasted rather than being a close call.
3. The one boundary condition: if you could get a clean fasted window at night, night might edge ahead via synergy — so “morning wins” is conditional on the night option being under-fasted, not an absolute.
4. Retatrutide doesn’t flip this. Slowed gastric emptying mildly reinforces morning-fasted as the cleanest window, and improved insulin sensitivity helps the pulse. The variable it introduces — deficit-driven hepatic GH resistance lowering IGF-1 — is independent of injection timing, so it doesn’t change the timing conclusion.
The caveat - Important one IMO
1. GHRH-receptor signaling directly promotes slow-wave sleep via the preoptic/anterior hypothalamus, independent of GH release.
2. That effect is time-locked — it needs the agonist centrally active around sleep, which a short-half-life peptide only achieves with an evening dose.
3. It’s GHRH-receptor-specific, not a GH/IGF-1 effect (the GHRP-2 dissociation), so the mechanism is consistent rather than just “more GH → better sleep.”
1. IGF-1 output tracks GH pulse amplitude, and meal-induced insulin blunts that pulse at the pituitary — so protecting the fasted state outranks protecting circadian timing.
2. IGF-1 is timing-insensitive anyway (long half-life, integrates GH exposure across the day, builds to steady state over ~2 weeks), so the “lost nocturnal synergy” of a morning shot carries essentially no cost. That’s what makes the trade clearly favor morning fasted rather than being a close call.
3. The one boundary condition: if you could get a clean fasted window at night, night might edge ahead via synergy — so “morning wins” is conditional on the night option being under-fasted, not an absolute.
4. Retatrutide doesn’t flip this. Slowed gastric emptying mildly reinforces morning-fasted as the cleanest window, and improved insulin sensitivity helps the pulse. The variable it introduces — deficit-driven hepatic GH resistance lowering IGF-1 — is independent of injection timing, so it doesn’t change the timing conclusion.
The caveat - Important one IMO
1. GHRH-receptor signaling directly promotes slow-wave sleep via the preoptic/anterior hypothalamus, independent of GH release.
2. That effect is time-locked — it needs the agonist centrally active around sleep, which a short-half-life peptide only achieves with an evening dose.
3. It’s GHRH-receptor-specific, not a GH/IGF-1 effect (the GHRP-2 dissociation), so the mechanism is consistent rather than just “more GH → better sleep.”
Yeah, the caveat matters to me. I care more about the sleep effect than the adipose tissue reduction, though that's also desirable.Hopefully there's enough of a gap between dinner and bedtime to get at least a partial benefit.
sheilarae74
GLP-1 Enthusiast
Thank you for sharing! I have 10lbs to go until I hit my goal weight on reta and I plan on starting tes/ipa soon after I do.
Dilbert4Life
GLP-1 Apprentice
So, you need to be fasted 3-4 hours before they pin and then a couple of hours fasting afterwards too? Like if you pin in morning, then how much gap required before you have breakfast?
rkbleddyn
GLP-1 Apprentice
I'm about ready to start it. I have noted that my Tirzepatide/diet combo is just not targeting that visceral fat, so an intervention needs to occur here. I'm thinking start at 500mcg. Maybe 250 is a better starting point?, not sure.
coach chickpea
GLP-1 Apprentice
2mg seems like a high dose and likely more side effects. 1mg is a typical dose.
2mg is the study dosage for relevant fat loss, 1mg is more for IGF-1 levels
coach chickpea
GLP-1 Apprentice
That might be the study, as is 12mg for reta but there comes alot more side effects with doses. I lost 17lbs and alot of lean tissue using .6mg of tesa daily for only 2 months
woundcarping
GLP-1 Specialist
How did tesa cause you to lose "alot of lean tissue", how did you measure the lean tissue loss, and what is lean tissue?
coach chickpea
GLP-1 Apprentice
Sorry mistyped, lost 17lbs and gained lean tissue. I have a hume scale and track my body comp daily.
coach chickpea
GLP-1 Apprentice
Lean tissue is muscle
That’s not really comparable. Retatrutide shows relevant fat-loss effects at doses well below 12 mg. Tesamorelin doesn’t have the same kind of evidence for lower doses.
If someone is aiming for the effect shown in studies, then the studied dose matters. What you do with that information is up to you.
Also, Tesamorelin’s fat-loss effect appears to be more visceral than subcutaneous, not general fat loss. Since its a GH/GHRH the lean mass is probably just the result of water-retention and is measured on these type of scales as lean mass
coach chickpea
GLP-1 Apprentice
Im very happy with my results. And as a hyper responder I always start low and slow, seems to work well for me. Of course everyone has to figure out how their body responds.
Steve_Burns
Recently Joined
🚫No Source Discussion🚫
I feel like everyone should get their IGF-1 levels tested before running any secretagogue. I did and found out my natural levels are 257, so it leaves me wondering if Tesa would even do anything beneficial.
Ticks
GLP-1 Apprentice
Yeah, there are more receptors in the visceral fat therefore its more affected than subcutaneous
hotsauceboss
GLP-1 Novice
🚫No Source Discussion🚫
I got mine tested and got an 87! My Tesa is on the way 😂
bogardbilla
GLP-1 Apprentice
2mg is the only prescription dosage, not only study/trial dosage. I don't think Tesamorelin is being prescribed at all "for IGF-1 levels."
