Reta tolerance or degraded?

[miameow]

How long are you staying on your current doses? I'm a firm believer in 4 weeks on a certain dose. Wait till you hit 8mg, shit happens.

I have been on reta for almost 6 months now, and I've been on each dose for exactly four weeks before titrating up by 1mg. Currently on week 2 of 6mg, and the noise and hunger are much stronger than even before I was on reta.

I just listened to a podcast episode with Jay Campbell (MindPump #2500) and he said he got extra hungry when at a higher dose of Reta and it was more effective at a smaller dose. https://podcasts.apple.com/us/podcast/mind-pump-raw-fitness-truth/id954100822?i=1000682068795

Hm that's interesting. Thanks for sharing. Unfortunately I don't think going back down to a lower dose is the answer for me at this stage, but I'm going to switch to cagri soon. I was going to give reta a last fighting chance at 6mg, but at this rate I will end up eating the entire fridge, freezer, and pantry.

 

[BNLFL]

I just listened to a podcast episode with Jay Campbell (MindPump #2500) and he said he got extra hungry when at a higher dose of Reta and it was more effective at a smaller dose. https://podcasts.apple.com/us/podcast/mind-pump-raw-fitness-truth/id954100822?i=1000682068795

110% wrong. I just did my 2nd 8mg, and it's killed my appetite. Much different than 2-6mg. I'm still eating because I need to, and get full extremely fast.

 

[RamCummins6.7]

Based on what I’m seeing, my vial is definitely degraded. Reconstituted Reta with BAC lasts about 28-30 days when stored properly in the fridge. I'm well past that, which means I need a higher dose that isn’t as effective to feel the minimal effect. Larger vials, unless you're doing larger doses, don’t store well for long periods. I'm going to use my last new 60mg vial and share it with my wife to make sure it’s used within 28 days of reconstitution. I’m also going to lower my dose since the new vial should be at full strength. After this, I’ll be using 10-20mg vials from now on.

 

[RetCurious]

Thats pretty interesting 🤔

They could be from different vendors which would reinforce the thought to stay away from cheap, no-name back street brands.

 

[Hawk_recon]

They could be from different vendors which would reinforce the thought to stay away from cheap, no-name back street brands.

For sure. Always sounds advice to follow

 

[RamCummins6.7]

UPDATE

So I tossed the rest of my previous 60mg vial and reconned a my last fresh 60mg with 3ml for me and my wife to both use. I pinned 5mg last week and i felt it wayyy more than 6.5mg with the other vial. Badically got everything feeling of it back. Slowing digestion, fuller feeling, lower appetite and the loss of the food noise. My wife is also feeling the same but with some slight nausea after injection. Also still pinning every 6th day.

 

[cujet]

UPDATE

So I tossed the rest of my previous 60mg vial and reconned a my last fresh 60mg with 3ml for me and my wife to both use. I pinned 5mg last week and i felt it wayyy more than 6.5mg with the other vial. Badically got everything feeling of it back. Slowing digestion, fuller feeling, lower appetite and the loss of the food noise. My wife is also feeling the same but with some slight nausea after injection. Also still pinning every 6th day.

Thanks for the update. There are differences between vendors, vials, percentage of fill over and under, and some degradation. I speculate that some Reta products degrade faster than others. The last batch I used was epic good. This batch is from a different vendor and I don't get the same results. I even gained 4 pounds over two weeks on the exact same diet, zero changes.

I increased the dose 1mg. If that does not work, I will try a different vendor that I have in the freezer. And if no results there, I will go back to my original Reta source.

The good news is that I am at my goal weight so plus or minus a few pounds is a non issue. My belt is still on the tightest hole I punched.

 

[BNLFL]

I've said this about one of my vendors 2 products. R30 and R50. He usually list the manufacturer, and this stuff hits like a train, almost too much. Funny thing, doesn't affect my wife at all.

 

[RetCurious]

Funny thing, doesn't affect my wife at all.

That blows my mind.

 

[RamCummins6.7]

I've said this about one of my vendors 2 products. R30 and R50. He usually list the manufacturer, and this stuff hits like a train, almost too much. Funny thing, doesn't affect my wife at all.

My wife just started feeling and it hit her like a freight train. But it’s funny it was the second dose in with the new vial it must have crept up on her. I also had her DOAs every 6 days too. But the little to no appetite and food noise are working which great but i have to remind her to hit her protein for the day.

It’s still kicking for me too. I’m curious to try the Reta from my new batches from new vendors that had excellent reviews and COAs and see if it hits different

 

[quicksilver80]

Update pertaining to this thread. My weight went up some then slingshotted down 7+ after my last post. These plateaus are about as understandable as a david lynch films plot. Guessing water mostly

 

[Oreos69]

Personally I was doing 3MG up from 2MG and it was doing pretty much nothing like the previous couple of weeks. This week i upped to 4.5 with a new vial and holy crap I'm having a hard week and going up 1.5mg seems like a stretch. Maybe I agitated the peptide too hard when I reconstituted the previous vial (this usually isnt a problem?) but it may be worth trying another vial.

 

[BNLFL]

This week i upped to 4.5 with a new vial and holy crap I'm having a hard week and going up 1.5mg seems like a stretch. Maybe I agitated the peptide too hard when I reconstituted the previous vial (this usually isnt a problem?) but it may be worth trying another vial.

Nah, don't toss the vial, and you didn't agitate it too hard.. Some of this stuff is just different. Yes, I mix based on the measured vial volume, not what it's marked as.

 

[RamCummins6.7]

Update pertaining to this thread. My weight went up some then slingshotted down 7+ after my last post. These plateaus are about as understandable as a david lynch films plot. Guessing water mostly

Thanks for the update

Personally I was doing 3MG up from 2MG and it was doing pretty much nothing like the previous couple of weeks. This week i upped to 4.5 with a new vial and holy crap I'm having a hard week and going up 1.5mg seems like a stretch. Maybe I agitated the peptide too hard when I reconstituted the previous vial (this usually isnt a problem?) but it may be worth trying another vial.

ive heard this and someone i believe on this thread said that at certain mgs the got nothing then they make a jump to 8mg and it smacked them again. My wife is visibly down weight and her waist is shrinking.

As far as agitated the peptide too much, what did you do when you reconned it? I just add the BAC and try to get it to squirt down the side of the vial then i roll the vial until it all dissolves.

 

[RamCummins6.7]

Nah, don't toss the vial, and you didn't agitate it too hard.. Some of this stuff is just different. Yes, I mix based on the measured vial volume, not what it's marked as.

Yes like stated here don’t toss it unless your well pst the 28-30 day mark on it

 

[BNLFL]

Yes like stated here don’t toss it unless your well pst the 28-30 day mark on it

Yep, I'll go 10 weeks reconstituted, but have never gone past 8 weeks. This current R50 is good for 7 doses at 8mg. 4 down, 3 to go. 7 weeks.

 

[Elgordoboy]

Same exact problem. Bumped up to 6mg last 2 weeks ago? Had some weird sides so i dropped back to 4. Been raising calories and lowering them and if anything been gaining weight every day. Usually see a 2 to 4 pound raise from morning to night. Now im swinging like 5 to 6. Drink a gallon of water a day. Under 2500c in deficit too regularly. Over 150g minimum of protein. Gym of heavy weight training 5 days a week.Nothing. no budge. At lowest 269 then keep bouncing around 270 to 275. its so bizarre

A 2 to 4lb increase morning to night isn’t anything unusual. I have a 2 to 4lb decrease from night to morning as well.

Update pertaining to this thread. My weight went up some then slingshotted down 7+ after my last post. These plateaus are about as understandable as a david lynch films plot. Guessing water mostly

Well known occurrence in weight loss and recomp. No worries

“The "whoosh effect" is a popular weight loss theory describing a sudden, overnight drop in weight after a long, frustrating plateau. According to the concept, the body flushes out water that has temporarily accumulated in shrinking fat cells, resulting in a sudden, sharp decline on the scale”

 

[sheilarae74]

“The "whoosh effect" is a popular weight loss theory describing a sudden, overnight drop in weight after a long, frustrating plateau. According to the concept, the body flushes out water that has temporarily accumulated in shrinking fat cells, resulting in a sudden, sharp decline on the scale”

This just happened to me recently. I had only lost 2 pounds in three weeks then all of a sudden, I lost 2 lbs in three days.

 

[PAPoots]

Water is a huge part of it. I find it takes a lot of water when taking GLPs to get your urine clear. I assume it is working if the urine is cloudy. Yellow is different story IMO, I think you are dehydrated if you see bright colors.

Someone posted a video on the site put together by a couple of compounders who said the agitation is a myth. Your body would be a wreck if you went on a run and all the peptides in your body separated due to agitation.

I bring my peptides upstairs daily and they aren't packed in foam or bubble wrap, I also might get distracted and they might sit out for 20 minutes.

I think there is as much disinformation about peptides out there as there is about politics.

Before I found the grey, my peptides were shipped via UPS already reconstituted and maybe they had an ice pack in the box. But they would be delivered to the porch or mailbox in the middle of summer. They worked as well as me throwing powder in the freezer and reconning fresh and storing in the fridge.

Accelerated degradation happens at 40C/104F.

Surprisingly it does start to degrade in the fridge quicker than I thought

Practical stability window at 39°F (refrigerator):​

• Chemically stable for ~7–14 days
• Biologically active for ~2–3 weeks
• Potency begins to decline meaningfully after ~28 days

 

[kj4otu]

Degrading Reta is a real thing. Mix up a new batch and you'll feel it pretty quickly. I did the same with too big of a vial and went 10 weeks on the same vial...the last 3 weeks were mostly discipline and determination. The next vial I mixed up was VERY noticeable in effect. Note mine was kept in the fridge...the 28 day limit is pretty real for Reta.

 

[RetCurious]

the 28 day limit is pretty real for Reta.

I would disagree with the caveat that not all are created and handled the same.

 

[BNLFL]

the 28 day limit is pretty real for Reta.

I'll disagree as well. I have a vial of R50 I just pinned #6 out of, and it feels the same. Pretty sure there's one more dose in there.

 

[kj4otu]

I would disagree with the caveat that not all are created and handled the same.

Yeah those tests are way off from what I experienced real world. I won't push pas 8 weeks again.

 

[RetCurious]

Yeah those tests are way off from what I experienced real world. I won't push pas 8 weeks again.

My first order was for 1 R12 kit to start off with and 1 R30 to continue on.
After submitting the order I was informed the R12 was OOS and would be a week or 2 behind the R30. Packages of supplies had been arriving for weeks and we had everything we needed for years we thought. 😆 So I reconned a chunky vial of R30 and hit it. R12 showed up 3 days later. 🤦‍♂️
Anyway. long story short we ran that first vial for at least 3 months and averaged over 2 lbs loss a week. Ideally, don't do that. I'm sure it wasn't as good as a fresh under 30 days batch and was courting trouble but it can be done if you're very careful in your handling of the product.
I've now got a kit of R12 that seems like it will be almost more trouble to recon and filter than it's worth.😆

 

[GLiPtest]

Appetite suppression decreasing, then feeling no appetite suppression, on the same dose, while weight remains stable isn’t tolerance, it’s how all GLPs work. On a given dose, your weight “thermostat”, the homeostasis weight your body wants to maintain, is set to a certain point. When you’re above that weight you experience appetite suppression, once you reach it appetite suppression stops. If you regain weight, on the same dose, appetite suppression will return until you return to the set weight again. To lose more you increase the dose, the homeostasis weight setting is now lower, and appetite suppression returns until you reach that weight.

If tolerance was developing, which has never once been observed in the thousands of participants in the 4 year+ trials of Sema and Tirz, weight would begin to return towards baseline.

Evidence is growing that interrupting treatment and restarting later can result in reduced efficacy, a type of tolerance, possibly from immunogenicity( developing an immunity to the drug). The same phenomenon has been observed with other peptide pharmaceuticals, sometimes causing a permanent decrease in effectiveness, not the “reset” people are hoping for.

More frequent injections, contaminants (especially the aggregates that form from degradation, or when reconstituting with too little water), can also contribute to this.

It’s essentially the same process vaccines use to train your immune system to recognize and destroy a certain molecule.

Filtering can help reduce the risk of this.

 

[Lyophilized]

Water is a huge part of it. I find it takes a lot of water when taking GLPs to get your urine clear. I assume it is working if the urine is cloudy. Yellow is different story IMO, I think you are dehydrated if you see bright colors.

Someone posted a video on the site put together by a couple of compounders who said the agitation is a myth. Your body would be a wreck if you went on a run and all the peptides in your body separated due to agitation.

I bring my peptides upstairs daily and they aren't packed in foam or bubble wrap, I also might get distracted and they might sit out for 20 minutes.

I think there is as much disinformation about peptides out there as there is about politics.

Before I found the grey, my peptides were shipped via UPS already reconstituted and maybe they had an ice pack in the box. But they would be delivered to the porch or mailbox in the middle of summer. They worked as well as me throwing powder in the freezer and reconning fresh and storing in the fridge.

Accelerated degradation happens at 40C/104F.

Surprisingly it does start to degrade in the fridge quicker than I thought

Practical stability window at 39°F (refrigerator):​

• Chemically stable for ~7–14 days
• Biologically active for ~2–3 weeks
• Potency begins to decline meaningfully after ~28 days

Why cloudy urine means "it's working"?

 

[woundcarping]

Water is a huge part of it. I find it takes a lot of water when taking GLPs to get your urine clear. I assume it is working if the urine is cloudy. Yellow is different story IMO, I think you are dehydrated if you see bright colors...

Clear urine is more likely to be over hydrated, although the risks from moderate over hydration are fairly minimal. Cloudy isn't usually a good thing. Bright colors make me think medications or supplements. Pale yellow is ideal or ok, darker is progressively dehydrated.

Surprisingly it does start to degrade in the fridge quicker than I thought

Practical stability window at 39°F (refrigerator):​

• Chemically stable for ~7–14 days
• Biologically active for ~2–3 weeks
• Potency begins to decline meaningfully after ~28 days

I don't know what that references, but it seems like a hallucination from AI. Only "biologically active" for 2-3 weeks, but potency doesn't decline until after 4 weeks...

 

[Lyophilized]

Clear urine is more likely to be over hydrated, although the risks from moderate over hydration are fairly minimal. Cloudy isn't usually a good thing. Bright colors make me think medications or supplements. Pale yellow is ideal or ok, darker is progressively dehydrated.




I don't know what that references, but it seems like a hallucination from AI. Only "biologically active" for 2-3 weeks, but potency doesn't decline until after 4 weeks...

I asked because yesterday was the pin day.
Reta, early morning, 7mg, taking since February
At night I noticed that the color of the urine was OK, but very cloudy (in fact opaque)
I felt some very small pain / discomfort

Today the urine was already clear and normal.. No discomfort

 

[WLBLD]

Appetite suppression decreasing, then feeling no appetite suppression, on the same dose, while weight remains stable isn’t tolerance, it’s how all GLPs work. On a given dose, your weight “thermostat”, the homeostasis weight your body wants to maintain, is set to a certain point. When you’re above that weight you experience appetite suppression, once you reach it appetite suppression stops. If you regain weight, on the same dose, appetite suppression will return until you return to the set weight again. To lose more you increase the dose, the homeostasis weight setting is now lower, and appetite suppression returns until you reach that weight.

If tolerance was developing, which has never once been observed in the thousands of participants in the 4 year+ trials of Sema and Tirz, weight would begin to return towards baseline.

Evidence is growing that interrupting treatment and restarting later can result in reduced efficacy, a type of tolerance, possibly from immunogenicity( developing an immunity to the drug). The same phenomenon has been observed with other peptide pharmaceuticals, sometimes causing a permanent decrease in effectiveness, not the “reset” people are hoping for.

More frequent injections, contaminants (especially the aggregates that form from degradation, or when reconstituting with too little water), can also contribute to this.

It’s essentially the same process vaccines use to train your immune system to recognize and destroy a certain molecule.

Filtering can help reduce the risk of this.

View attachment 26913View attachment 26910

You mentioned recon with too little water. Is there a % it should be to make sure its enough or a standard? I know the EL comes with a higher amount than most like going grey