woundcarping
GLP-1 Specialist
Overweight TRT Considerations
- Thread starter msyntakz
- Start date
Moonshine72
GLP-1 Novice
🚫No Source Discussion🚫
Damn, I had never heard of TRT's honeymoon phase. I have only noticed a slight improvement in sleep and tone, but no increase in libido.
sfkid
GLP-1 Enthusiast
Are you taking any aromatase inhibitor?
Moonshine72
GLP-1 Novice
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I live in way upstate NY; I’ll have to check if they have any close by.
Moonshine72
GLP-1 Novice
🚫No Source Discussion🚫
No, I was subscribed to a 1 mg tablet of anastrozole by TRTnation in case I noticed any estrogen or titty pain.
Get your blood/hormones done before you even consider trt especially if you don’t know what you’re doing. Keep on losing weight as the weight is what causing the problems you’re encountering. Eat clean start training.
Whilst it is true that test gives you a great feeling especially confidence take it from me (yes a stranger on the internet) I messed up a post cycle therapy and have screwed my fertility. It’s reversible but gonna take a while.
Interesting. Well, everyone's different. At the end of your first 90 days, you need to review the ADAMS questionnaire https://www.nature.com/articles/ijir200935 and see how you feel. Those results can be read against your blood lab work and the Dr will adjust your protocol.
Gt3294a
GLP-1 Enthusiast
Are you sure they prescribed you 1mg? That is a heavy dose. For small e2 adjustments, smaller dosages of .125mg are common. Crashing e2 is worse than high e2.
MikeyMike
GLP-1 Apprentice
I am about 6 weeks into my TRT and libido is through the roof! Started building about 2 weeks ago. I had heard about this as well. My wife is loving it, I just hope it doesn't wane too much. How long have you been on it and what dose?
woundcarping
GLP-1 Specialist
Yep, they want you to split them.
chewonmysac
GLP-1 Enthusiast
My consult with TRT Nation is today. Already paid for 2 months. This appointment took 2 weeks. During that time, I have done exhaustive daily research on the pros/cons of TRT. There is a lot to pay attention to, especially constant bloodwork and possible add-ons to minimize the effects of Estrogen. This is a completely different rabbit hole than GLP or Peps. Not sure if I want to really commit to this. My biggest fear is to unwind the last year of dramatic success with Tirz and other peps. At the same time, I do not want to waste this window of momentum in my body recomposition. Still 50/50 whether I will start. Total test is 417, and free is 5.7.
I was in the low 300s TT and my Uro started me at 70mg/wk and the first couple months was a noticeable improvement! After 90 days I moved up to 100mg/wk and held there for 5 years and just moved up to 150/wk. I have never needed to manage estrogen. Just my honest opinion, if your clinic puts your weekly dose at a level that involves a Rx for an AI "just in case you need it" then that clinic is pushing the envelope on the dose.
I am in my 4th week right now, 120mg/week test cyp. I was tested, and my total test was 285 ng/dL, and free was 9.4 ng/dL. So, I decided to move forward. I agree that a large portion of my issues are from the weight I am carrying. I am now 90 lbs down from my heaviest, and there are big improvements for sure, but I am seeking more mental improvements. The physical benefits are a nice bonus.
I am injecting 4 times per week for more stable blood levels, and it seems to be working well. I have had no sides to speak of in these 4 weeks, even at my body fat percentage. Never touched the AI.
I am guessing my endogenous supply must be reducing by now, as I hit the honeymoon phase for about a week, and now it's leveling back. But sleep is great, mood is stable, pumps in the gym are great, and weight is still trending down. The scale slowed a bit, but I am assuming some water retention, as calories are unchanged.
As far as fertility, I am 37 with two kids, and I am done. I was entertaining a vasectomy anyway, so maybe chemically it will get the job done haha.
woundcarping
GLP-1 Specialist
Still waiting on my DHT results from last Monday's labs, but going from 120mg/week to 180mg/week raised my hematocrit to the point of donating blood Tuesday. I'll go tomorrow to see what my levels are after donation.
I started supplemental creatine at the end of April... I'm expecting I've got an extra 3-6lb of lean mass from that, but haven't confirmed that with a DEXA yet.
| Marker | 03-16-2026 | 05-18-2026 | Change |
|---|---|---|---|
| Weight | 247lb | 227lb | -20 |
| Total Testosterone | 680.8 ng/dL | 774 ng/dL | +93.2 |
| Free Testosterone | 23.4 pg/mL | 24.4 pg/mL | +1.0 |
| Estradiol Sensitive | 26.2 pg/mL | 21.0 pg/mL | -5.2 |
| SHBG | 18.6 nmol/L | 24.3 nmol/L | +5.7 |
| DHT | 20ng/dL | Pending | — |
| Hematocrit | 48.3% | 56.4% | +8.1 |
sfkid
GLP-1 Enthusiast
Hema is very high... Donating will get it down maybe 5 points but it will creep back up.
Did you take the lab after pinning? If you did that could be a peak.
You need pound water like your life dependent on it.
How frequent are you pinning?
woundcarping
GLP-1 Specialist
I increased my dose from 120mg/week to 180mg between those labs based on the DHT being low. I've cut the dose back to 150mg based on the hematocrit peaking and the total/free basically shrugging it off.
I take TRT labs the same point in every week. Like the quoted post said, I pin 3x weekly.
It's possible I had less than ideal hydration the day before May's labs, although I drank my usual amount of water before the draw.
I started TRT on 1/19. Dose increase on 3/25. Dose reduction on 5/20. I have labs planned for tomorrow, June, July, August, and Oct/Nov... data comes in, I'll adjust my monitoring schedule.
| Date | HCT |
|---|---|
| 12-30-2025 | 49.4 |
| 03-16-2026 | 48.3 |
| 04-07-2026 | 53.3 |
| 04-20-2026 | 51.1 |
| 05-18-2026 | 56.4 |
Moonshine72
GLP-1 Novice
🚫No Source Discussion🚫
Yeah, I’m suppose to split them. But I haven’t felt any titty pain or seen any overgrowth of back hair yet to take it
woundcarping
GLP-1 Specialist
I don't think estrogen commonly causes back hair...
Moonshine72
GLP-1 Novice
🚫No Source Discussion🚫
Yeah, that’s what the prescribing nurse told me lol. I didn't think that was a thing myself.
woundcarping
GLP-1 Specialist
Elevated testosterone can cause hair loss on your head and hair growth on your body.
Well, got my partial 6-week blood results back, and the blood is indeed thickening:
It's possible that it's an elevated level from dehydration. I have such a hard time with it on these GLP1s. This is on 120mg test cyp split shots, 4x 30mg per week. Yet to see what the hormone side looks like, but wanted to see what success folks have had lowering hematocrit without donating. I really don't want to get into that rebound cycle.
EDIT: Hematocrit was 46.6 previously, for context.
It's possible that it's an elevated level from dehydration. I have such a hard time with it on these GLP1s. This is on 120mg test cyp split shots, 4x 30mg per week. Yet to see what the hormone side looks like, but wanted to see what success folks have had lowering hematocrit without donating. I really don't want to get into that rebound cycle.
EDIT: Hematocrit was 46.6 previously, for context.
sfkid
GLP-1 Enthusiast
if your drinking enough water and doing enough cardio then the next thing to change is to switch to subq injections from IM. Subq will have slower up take than IM and produce more steady levels.
How long was your last injection from the blood test day?
Typically injections are Mon,Wed,Friday and test days are Monday. This way you give 2 days for levels to stable out, not to capture peaks levels, before doing blood work.
I’m doing 4 sub q per week already. I tested yesterday (Friday) before my injection, last injection was Wednesday morning. I definitely need to up my water and I can always use more cardio. I guess those are my next goals.
sfkid
GLP-1 Enthusiast
What did your total test/free come back as on 120mg?
Skidude
Illegitimi non carborundum
I was scheduled for blood work on Thursday but ended up having entirely too much whiskey on Wednesday so was concerned as that can affect hematocrit levels.
I also take a diuretic for blood pressure which can be a contributing factor.
I also take a diuretic for blood pressure which can be a contributing factor.
Still awaiting those results. I am anxious to see where I'm at as I am nervous to increase dosage with these results on the blood thickness. Again, there are still levers I can pull to correct, but we shall see.
The overall advice I keep hearing is not to donate if possible.
I really want to focus on good hydration and fitness the next six weeks and recheck CBC and see where it lands.
sfkid
GLP-1 Enthusiast
One thing thing is to check your blood pressure. If you have good read outs then hema levels become less worrisome.
But overall , yes , pound lots of water and do more walking daily....
jsc1980
GLP-1 Novice
🚫No Source Discussion🚫
I've been on trt for 14 years and have tried a variety of things re hct and hemo. My previous endo had me on 70mg/week because my hct was slightly elevated (52) on 100mg/week. The dose was too low so I was getting negatives without all the positives. I decided to swap to trt nation and self-manage. I've been doing trt over a decade, I'm not a stranger. Currently running 70mg x 2 per week. Making sure to stay hydrated. Also taking grapefruit seed extract morning and night. Last labs came back at 51.2 hct, 16.7 hemo. That was also fasted, so likely less hydrated than normal. So double the trt dose and decrease in hct, and feeling good.
I'll donate blood next week just to help keep it on the lower side too, but probably not necessary.
I also bought an at-home hemo meter and check it every few days. Often times we know ourselves best and need to do what we know is best.
In terms of AI, trt nation usually includes it in case so you don't have to wait on a separate script if you do end up needing it. They also wrote my script for 200mg/wk but said to start lower and I can always bump up if needed. If not, the bottle will just last longer.
I'll donate blood next week just to help keep it on the lower side too, but probably not necessary.
I also bought an at-home hemo meter and check it every few days. Often times we know ourselves best and need to do what we know is best.
In terms of AI, trt nation usually includes it in case so you don't have to wait on a separate script if you do end up needing it. They also wrote my script for 200mg/wk but said to start lower and I can always bump up if needed. If not, the bottle will just last longer.
rmhla
GLP-1 Novice
🚫No Source Discussion🚫
Good post and to be honest being over weighr has allot to play in erectile dysfunction and way more then I think studies are telling us.
Cialis can definitely get you pumps in the gym taken an hour before, personally for me it was a huge difference compared to just watting enough carbs before my work out and the day before, also straight water to drink during work out with dextrose put in. I felt did more for me then Cialis.
I was once 328lbs 42% bf currently 218lbs 13% bf
So I understand wanting to get on test for trt but just get a blood test .... see what your ranges are. Plus it will help you know down the road as well or what else you'll need to work on to feel better, could be something more complex or very simple.
Personality my moods changed when I got up early rather then sleep later and early I mean 4am , 430am, lots little things added up to helping me be less stressful as well like no social media for the most part.. sounds strange but it kills libido, kills positive thinking too.
Over all i went on TRT Toro Testosterone Cypionate after blood work showed me at 192 which is lower end of the scale im now over 1000+ due to using 500mg weekly (much different once your lean) they say get to your teens in bf and consider peds...
Lots info out there so just don't through and check recheck information before you hope on. Biggest thing with test is hematocrit spike...
Hope you keep succeeding and stay positive.
rmhla
GLP-1 Novice
🚫No Source Discussion🚫
Grapefruit extract is all good but using blood pressure meds it doesn't go well together.
