Canadian, cryptorchidism, cancer => seeking progress

islandtime50

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I am 51, I was in excellent health about 4 years ago - by that I mean working out twice a day except on run days when I only worked out once and taking one rest day a week barring injury. For the last 4 years, I pretty much fell off a cliff - I started a new career, we all went through COVID, and I found out I had colon cancer.
The cancer is as in the bag as that sort of thing can be - I have the best prognosis you can have for a guy who packed a tumour for 8-10 years and had it invade surrounding tissue and then get run down so bad I would have accepted it was my time in that moment. Apparently, 46 sites were sampled surrounding what used to be my colon and they all came back negative and I do not even need chemo ... see you in 6 months. I got downgraded from stage 3 or 4 to 2 asked on my unexpected results.

It's been six months. There have been changes to my diet, I really can't drink alcohol, I can't tolerate creatine any more, and I'm really not making any physical/fitness progress for the first time in my life.

I am 51 for the first time, I am still not up to the same energy levels I hope to regain and I am hanging in at 220lbs 29%bf versus my former glories.

I also have a cool little scar down on my abdomen sort of just inboard and below my right hip bone (I think the term is inguinal) that is 45 years old now. I had a testicle that didn't want to descend and at the age of 6 I had an orchiopexy. Almost by definition, this is an issue of hypogonadism from birth as male hormones are what drives most of this process when it happens naturally.

SIDE NOTE - As a result, I have one little, underdeveloped testicle that I am also supposed to watch for cancer. It's not supposed to work very well but I can assure you it pumps out swimmers because, in an effort to relieve my wife from the burden of birth control, I tried to have a vasectomy. The expert in this area actually badly hurt me by performing a vasectomy on the presumed functional twin, elected to bypass the little fella, and lab results from the follow up show that we would still make babies (something I/we have had no problems with in the past) rendering the entire process not only painful and angering but, ultimately, futile. Beware rich little bored men with knives.

In the intervening 4 years another thing happened along with my 50th and 51st birthdays, cancer and weight gain ... no more wood. No more real drive for it either and well, we aren't going to make any babies anyway. Pretty noticeable little change that, can't recommend. My wife never had the same drive as I had so I think she is frankly quite relieved. However, this is a problem for me.

So the small ball thing first. I think. This has been a life long thing and not something I've really talked about. I assure you there is a lot of casual glancing near urinals and during communal showers during sports or at the municipal pool. I've noticed (and it's been noted) that I'm not built the same as everyone else, or at least, on the spectrum of male sexual physiology I run a little out of the bumpy part of the bell curve. Hasn't really been much of an issue since puberty. However, I'm a low T guy and have been for my entire life, I just didn't think of it that way.

However, I'm thinking it now. I'm thinking TRT. My doctor (we're new to each other since immediately before the cancer discovery) is not going to be any help. In fact, the only answer he has for me is anti-depressants. I will admit, I was down before the emergency, life-saving bowel resection but it did take four years of no results, a relatively late career change (and it's concomitant poverty), and near-death to get there. I am really strongly disinterested, if not opposed, to anti-depressants. New blood work is going to be necessary. I was at 11.6nmol/L in late Feb. However, I also have ferritin problem (originally due to bleeding from my tumour), a weird high RDW on my CBC that could be from the same or the infusion I got right before my surgery. Anyway, the long and short is I have a doctor I don't know well or trust and he's not going to help with any of this.

I want to look at optimal levels of testosterone via trt and then follow up with tirz or reta once that is stable. From what I can see I am looking at UpGuys as a telehealth for trt or simply go grey and get blood work through teletest.ca. I live at around the mid-point of Vancouver Island in B.C.

I have an appointment with my doctor this week and I've thought about trying to get a referral for an endocrinologist or a urologist as what I have is in their respective wheelhouses. However, I feel that the current state of health care looks to be excellent with life-saving interventions and absolute shit with actual health. Health and wellness look to have been sold off to third parties.

Questions? Comments? ... Dirty Jokes?
 
My thought would be to get on Reta before trt.

Losing some weight might give you confidence and stamina back. Fat is like an organ, it releases hormones, it has inertia on your energy.

Reta will help you deal with a lot of the built up visceral fat, water and inflammation too which should give you a noticeable bounce.

Reta also has less long term considerations than TRT. So you may as well give it a shot.
 
In Australia most of the time you are going to be advised to lose weight if t is low and you are overweight, not a huge fan of that approach, but if you start a glp like reta and lose some weight there is a good chance your t levels will increase, and extra t may not be needed. The US seems to often prescribe test therapy to older men with lowish test levels, no idea what Canada is like for that, if I had to guess maybe more like Australia, where it is endocrinologist only.

A study recently showed dramatically increased average life expectancy in persons with colon cancer on GLP therapy. This is a long way from proven, but there are quite a few early studies showing similar effects, including one on breast cancer, and many preclinical bits of research pointing in that direction. So another possible reason for glp treatment. None of the research has been done on reta and cancer yet as it is not approved , but so far it seems to be showing most of the same effects as tirz and sema in other areas.

I have no idea if test therapy influences cancer growth, but I would suggest get an expert opinion ( endocrinologist / oncologist ) on that before going ahead. Or at least some searches on google scholar .
 
On this site there is a link to GLP1's and Retatrutide reducing cancer risk, improving cancer surviveablity. Search for it as it may apply to you.
 
My thought would be to get on Reta before trt.

Losing some weight might give you confidence and stamina back. Fat is like an organ, it releases hormones, it has inertia on your energy.

Reta will help you deal with a lot of the built up visceral fat, water and inflammation too which should give you a noticeable bounce.

Reta also has less long term considerations than TRT. So you may as well give it a shot.
First of all, thank you for taking the time to respond! I am new and honestly trying to formulate a plan.

I have heard others make arguments both ways. I am currently 183cm (6') and 98kg (226lbs), not wildly out of control but not super happy by any means. My Renpho scale is telling me 17.5% body fat (but it was dead this morning and was charging all day). We won't even talk about BMI because I have always skewed that number super hard.

I know losing weight can help with test and I know I am eating too much right now. I have exercised an iron grip of calories and macros in the past and know I can do it again. I have never felt so low on energy for such a protracted period of my life though.

Thanks again
 
In Australia most of the time you are going to be advised to lose weight if t is low and you are overweight, not a huge fan of that approach, but if you start a glp like reta and lose some weight there is a good chance your t levels will increase, and extra t may not be needed. The US seems to often prescribe test therapy to older men with lowish test levels, no idea what Canada is like for that, if I had to guess maybe more like Australia, where it is endocrinologist only.

A study recently showed dramatically increased average life expectancy in persons with colon cancer on GLP therapy. This is a long way from proven, but there are quite a few early studies showing similar effects, including one on breast cancer, and many preclinical bits of research pointing in that direction. So another possible reason for glp treatment. None of the research has been done on reta and cancer yet as it is not approved , but so far it seems to be showing most of the same effects as tirz and sema in other areas.

I have no idea if test therapy influences cancer growth, but I would suggest get an expert opinion ( endocrinologist / oncologist ) on that before going ahead. Or at least some searches on google scholar .
Thank you also for your thoughts!

I do think Canada is probably close to Australia than the US for trt. That said, it looks like there is a wellness clinic in most cities doing brisk business in trt and there are definitely staring to be online telehealth options.

It looks like doctors are looking for below 8nmol/L and I am at 11.6 (I checked my last lab). In the US below 12 seems to be enough.

I had heard about glp being positively correlated with better outcomes for cancer but iirc it was posited to be related to a general reduction in inflammation, etc.

Test seems to be a bit more contested. There is some (contested) concern around the effects on the prostate. It looks like a ton of relatively recent work largely contesting earlier assumptions about trt potentially increasing cancer risk.

I don't seem to have access to BC Cancer since my strongly negative post-surgery results. I know that at least one was consulted but I have not met with anyone other than my GP and surgeon. My best option looks like an endocrinologist and I was going to ask for a referral anyway. I have just found out that there are online endocrine referrals as a pathway as well.

Thank you again. I have a lot to think about.
 
I was on the path to self administering and then just going to labs to check blood but got slapped down pretty hard here and on reddit. Apparently a real clinic with a dr is much preferred, even though it seems most of the clinics are just vessels to milk you of your money?

Ive since stepped back ( I had actually pinned test for the first time this week ) and continuing to research all of this.

My current reading material is r/testosterone wiki..

You and I are the same age, and I am sorry for your poor luck with the cancer, I just had a colonoscopy myself.
 

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I was on the path to self administering and then just going to labs to check blood but got slapped down pretty hard here and on reddit. Apparently a real clinic with a dr is much preferred, even though it seems most of the clinics are just vessels to milk you of your money?

Ive since stepped back ( I had actually pinned test for the first time this week ) and continuing to research all of this.

My current reading material is r/testosterone wiki..

You and I are the same age, and I am sorry for your poor luck with the cancer, I just had a colonoscopy myself.
Thank you, Gr33dy!

I just finished reading that thread. I have a phone call with UpGuys tomorrow (Cdn trt clinic) and an appt with my GP on Thursday.

I don't think my GP is going to help with a damn thing ... maybe a referral to an endocrinologist. My main goal is to get a fresh lab. My last lab said my rdw was too high and ferritin too low. Everything else was normal (given that relatively low test is considered normal here).

It looks like UpGuys want a consultation fee of $50 and then likely $200-300 monthly for test. I will know more tomorrow (and then more again on Thursday).

I have been lurking on Reddit for years and the glp and trt threads in particular for quite a while.

Any immediate decision is premature as I need to see improvement or correction for iron first (I am still taking iron supplements until I see otherwise). I am working out and running again but I am still low.
 
Thank you also for your thoughts!

I do think Canada is probably close to Australia than the US for trt. That said, it looks like there is a wellness clinic in most cities doing brisk business in trt and there are definitely staring to be online telehealth options.

It looks like doctors are looking for below 8nmol/L and I am at 11.6 (I checked my last lab). In the US below 12 seems to be enough.

I had heard about glp being positively correlated with better outcomes for cancer but iirc it was posited to be related to a general reduction in inflammation, etc.

Test seems to be a bit more contested. There is some (contested) concern around the effects on the prostate. It looks like a ton of relatively recent work largely contesting earlier assumptions about trt potentially increasing cancer risk.

I don't seem to have access to BC Cancer since my strongly negative post-surgery results. I know that at least one was consulted but I have not met with anyone other than my GP and surgeon. My best option looks like an endocrinologist and I was going to ask for a referral anyway. I have just found out that there are online endocrine referrals as a pathway as well.

Thank you again. I have a lot to think about.
This is the study I was thinking of -"Association between glucagon-like peptide-1 receptor agonists and colorectal cancer survival: A population-based cohort study "
Diabetes Metab 2026 Mar;52(2):101734.
doi: 10.1016/j.diabet.2026.101734. Epub 2026 Jan 16
"GLP1-RA users had a significantly reduced all-cause mortality rate (11.5%) compared with non-users a (20.4%), with a hazard ratio of 0.58 (95%CI: 0.45-0.76; P < 0.001). Metastasis-free survival rate were 5.3% in the GLP1-RA cohort versus 8.9% in the matched non-user cohort, with a hazard ratio of 0.60 (95%CI: 0.40-0.87; P = 0.01)."

If this turns out to be real, and it is a big if, half the rate of metastasis and half the mortality rate, makes it possibly more effective than a lot of more standard treatments for malignancy. Still probably better evidence even at this stage than for a lot of alternative or supplement type therapies. If I had it and thankfully despite having ulcerative colits for decades, I had a clean scope recently, I would consider it based on current evidence, though no doctor is going to say that at this stage.

Sounds like you have a decent grasp of what options exist for trt, and the unfortunate politics of it. There would be a huge outcry if women were denied HRT the way men are refused TRT. It is not quite that simple but I think sexism and weird attitudes about men increasing testosterone are sort of cheating comes into it. The TRT clinics are a response to this, but they just tend to give it to everyone who asks, which is possibly going a bit too far the other way.
 

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