Hunger on injection day?

[BubbaZ]

I have noticed the last few weeks that on my injection day for Tirz, I am hungrier than normal. I have never had this issue before. This is specifically AFTER the injection.

Anyone else experience this?

 

[SeaGypsy]

What's your dose and how long at that dose? When you titrate up it should help that.

 

[indolent]

Tirzepatide has a half-life of ~5 days, so some people experience what you're finding.

A solution is split-dosing (half the weekly total, pinned every 3.5 days or so). Another is pinning on a different interval -- every six days or every five days -- but reducing the dosage.

Use the free online plotter tool to visualize the levels in your system.

 

[BubbaZ]

What's your dose and how long at that dose? When you titrate up it should help that.

I don’t feel like I need to titrate up, the next day I am fine and even on the day of the injection I am fine. It is just by the afternoon of the day I get the injection that I am feeling it. Plus I am already at 15mg.

 

[SeaGypsy]

I don’t feel like I need to titrate up, the next day I am fine and even on the day of the injection I am fine. It is just by the afternoon of the day I get the injection that I am feeling it. Plus I am already at 15mg.

In that case I would really go with what indolent stated above if it's really bothersome for you. I myself normally get the hunger back the day before my pin. I roll with it and use that time to cram in more protien

 

[texmexpep]

A LOT of my rat family stuck to a 5 day schedule and kept the actual dose they took lower. Didn't have that issue. (most are just maintaining now)
Some also added a tiny bit of sema every 7 days.

 

[Flash-BCR]

Normal response...for me, the first day of pinning is not noticeable, I might start some burps and rumbling overnight, but the food noise drops by the next day, and even more the third day...then it levels and yeah, by the fifth, sixth day food noise starts to build...I have been trying a split dose the last 3-4 weeks and I find it to be better. If I change from that, it would be to do a 5 or 6 day between dose schedule...GL with your journey!... 👍 😎

 

[lessthanhalf]

It takes about 24 hours to hit peak blood levels after a dose, so minimum blood levels would be just before the next dose, and rising after that to a peak 24h later or so. Immediately after the dose levels will be low but should be rising.

If it was due to the drug wearing off it should be worse before the next dose not after, and if it was nausea as a side effect, it should be worse 24 hours after the dose.

My guess and it is a guess, is maybe it is a bit of low grade nausea, as the blood levels are rising, it can be really hard to tell the difference between that and hunger sometimes. I had a year of nausea and hunger on low dose ozempic, which I was using to try to reduce being permanently starving after losing 70kg without glps. And I found I was often both hungry and nauseous, or could not tell which was which, or had nausea that I could fix by eating a tiny bit of chocolate or sugared ginger.

It is not hard to try splitting doses to see if it works.

 

[BBA1969]

Split dosing worked like a charm for me. No more bad sides and a steady hunger suppression.

 

[WLBLD]

I read somewhere someone was having the same issue, they changed their timing to night closer to bed & slept through that & would wake up fine the next day without those symptoms

 

[BubbaZ]

I read somewhere someone was having the same issue, they changed their timing to night closer to bed & slept through that & would wake up fine the next day without those symptoms

That actually makes a lot of sense. I might try it. Since it usually hits a couple of hours after the injection, I could see how sleeping through it would help.

 

[WLBLD]

That actually makes a lot of sense. I might try it. Since it usually hits a couple of hours after the injection, I could see how sleeping through it would help.

Hope that works for you! 🙂

 

[fatjacked]

i've always pinned in the morning because i've heard some people report sleep difficulty after a dose, though now that i think about it i'm not sure that makes sense given what we know about time to peak blood levels & half life.

i typically pin on weekends after a heavy fasted cardio session, which also makes me a little less hungry for a couple hours after, but that's just coincidence.

 

[Frandroid]

I read somewhere someone was having the same issue, they changed their timing to night closer to bed & slept through that & would wake up fine the next day without those symptoms

I experienced the same and this worked for me. I hope it'll work for you too, OP.

 

[BubbaZ]

Hope that works for you! 🙂

This was the ticket. It helped immensely! Thanks for the suggestion!!!

 

[Jfrick11]

I have noticed the last few weeks that on my injection day for Tirz, I am hungrier than normal. I have never had this issue before. This is specifically AFTER the injection.

Anyone else experience this?

I've seen quite a few people mention this.

A 5-day half-life doesn't mean the drug suddenly wears off before the next dose. After several weeks, most people reach fairly stable concentrations, with modest peaks and troughs vs dramatic swings. So injection day hunger isn't fully explained by pharmacokinetics alone.

So... Although I don't know exactly why it happens, I don't think it's necessarily a bad thing. Personally, I don't think the goal is to never feel hungry. A little hunger is healthy and makes it much easier to get the protein and nutrition your body needs. I'd enjoy the appetite and make it a good protein day! 💪