Reta from one supplier (but not others) burning when injected.

[Scrap]

Basically, title. I purchased from one of the well-known suppliers recently, and the injections burn INTENSELY, but only during the injection itself and then for a few seconds after. It doesn’t matter if it’s cold, room temp, the injection site, if it’s angled, or straight in. It’s not the BAC water either because I injected that straight to test and it doesn’t hurt at all. I also tried it with Reta from another supplier and it didn’t burn.

I suppose I could send off for testing, but I was curious if anyone had any ideas on why one supplier’s Reta would burn and another’s would not.

 

[Calm Logic]

Have you tried adding more BAC water?

GENERAL QUESTION ON INJECTIONS WITH COMPOUNDED PEPTIDES

Jan 4, 2024

Hello
I am new, My name is Christy. I started on Sema for about 5 to 6 months then switched Tirz for 4 weeks and now on Reta for my 5th week. I have lost a total of 51lbs.
I wanted to see if anyone else has some stinging when injecting Reta. I did not have any stinging with Sema and Tirz.
I am having to inject slowly into the skin. I am taking 5mg of Reta. I just reconstituted a 10mg bottle with 1ml Bac water and injected half of it ( .5ml/5 units)
This time I had to use two injection sites due to stinging. It is not an immediate burn but stings once I get to the halfway point or inject to...

• christy0110
• Replies: 9
• Forum: Public Square

 

[dogmom]

I had that with Amo/now bfflist. Manufacture date I think was in Nov 2024. It stung like crazy and felt like a tiny tiny metal ball under my skin. Never felt anything like it before. And it lasted for about 2 to 3 hours. I will say it worked and seemed to be real reta. But definitely uncomfortable. I set it aside and will only use it as a last resort.

 

[Guyroscoe]

I had that with Amo/now bfflist. Manufacture date I think was in Nov 2024. It stung like crazy and felt like a tiny tiny metal ball under my skin. Never felt anything like it before. And it lasted for about 2 to 3 hours. I will say it worked and seemed to be real reta. But definitely uncomfortable. I set it aside and will only use it as a last resort.

That's interesting. I actually came here today to ask about where people get their BAC water because the Tirz I got from BFF really stings. I did a half dose on my first round, no stinging. A week later, a full dose, a little bit of initial stinging, and then another full dose 2 days ago with A LOT of stinging, and not just on entry but for at least an hour after dose.

 

[Skidude]

Hopefully this is not a revisit of last fall when there were numerous complaints about stinging Tirz from this vendor. I have had good luck with them and the problem seemed to be resolved, but it is worth keeping an eye out for others having this issue. At the time it tested fine, here is a snippet from STG, you can find the link in my signature.

They were known as amolist at the time and there are many threads in this and other locations surrounding the issue.

 

[Scrap]

That's interesting. I actually came here today to ask about where people get their BAC water because the Tirz I got from BFF really stings. I did a half dose on my first round, no stinging. A week later, a full dose, a little bit of initial stinging, and then another full dose 2 days ago with A LOT of stinging, and not just on entry but for at least an hour after dose.

The sting stopped when I switched to Hospira. My reta was from bff.

 

[hexagonal]

Could be a pH issue. I've run into some Chinese supplier BAC being fairly different pHs than Hospira.

That's why I moved to using exclusively Hospira - not wanting to have to deal with pH stuff. I still think we should be able to trust these vendors to make BAC if we're trusting them to make peptides, but... if they're not bothering to try and set it to a standard pH, this is where we end up.

 

[fvmnhdrt]

does bfflist ship from a domestic warehouse?

 

[dogmom]

Could be a pH issue. I've run into some Chinese supplier BAC being fairly different pHs than Hospira.

That's why I moved to using exclusively Hospira - not wanting to have to deal with pH stuff. I still think we should be able to trust these vendors to make BAC if we're trusting them to make peptides, but... if they're not bothering to try and set it to a standard pH, this is where we end up.

I only use Hospira and got the stinging with Amo/Bfflist and only them. It is definitely something this vendor is doing.

 

[Guyroscoe]

The sting stopped when I switched to Hospira. My reta was from bff.

I also bought Reta from bff, no sting at all.

The sting stopped when I switched to Hospira. My reta was from bff.

where do you source your hospira?

 

[trinaisfive]

I have never had an issue with amo. Used them for 1.5 years with all the family in it now too. I would add double water that means the dose will be double and see if that helps. I bought lidocaine to add to nad for that reason too.

 

[zpped]

does bfflist ship from a domestic warehouse?

That kind of stuff changes on a daily basis. You can email them and ask.

 

[Augu5+1ne]

no offense meant, just curious - you didn't use hospira saline to reconstitute your peptides did you? Also, you did syringe filter using sterile technique and 0.22micron filter didn't you? If not either of these things could explain the burning, though not a definite thing.

 

[flsailfish22]

I only use Hospira and got the stinging with Amo/Bfflist and only them. It is definitely something this vendor is doing.

I would test the PH of the solution. If it doesn't cause an infection but still burns in my experience it is likely a PH issue. Adding more BAC may help if it's a PH issue. Trying to fix the PH besides adding more BAC will likely cause the solution to crash.

 

[flsailfish22]

I have never had an issue with amo. Used them for 1.5 years with all the family in it now too. I would add double water that means the dose will be double and see if that helps. I bought lidocaine to add to nad for that reason too.

NAD+ is typically pretty acidic. I make my own and as long as the PH is 5 to 5.5 I have zero issues doing IM injections. One issue with NAD+ is basically the solution will crash quickly once over a PH of 5. At around PH of 7.5 it will be converted from NAD+ to the reduced form NADH. To give you an example of how quickly this can happen. .38 to .40 NaOH will get you to a PH of 5. Even just a single extra grain of NaOH will shoot the solution to a PH of 9.

 

[TooBigtoFail]

Try more bac. For most peps, I use 25-40u.Tirz 45u. For me, only Ghk-cu stings. Reta does not stink but am only at 1.5mg doses.

When you added Bac to the 'bad' vial, was the water sucked in without pressing the syringe? That would indicate vacuum (no air) and a good sign. I always expect my vials to be under vacuum.

I just threw out 10 Reta vials from ASC Tuk, Jano #45442, June 2024 test. They had no more vacuum and first vial in the batch would not recon properly. Was not going to gamble with ISR, sting, or infection (air in=>bacteria in).

I inject Cagri with pH of 4.0-4.5 (acidic). No sting. Do test your pH in case it is really high.

 

[IronPaw.]

NAD+ is typically pretty acidic. I make my own and as long as the PH is 5 to 5.5 I have zero issues doing IM injections. One issue with NAD+ is basically the solution will crash quickly once over a PH of 5. At around PH of 7.5 it will be converted from NAD+ to the reduced form NADH. To give you an example of how quickly this can happen. .38 to .40 NaOH will get you to a PH of 5. Even just a single extra grain of NaOH will shoot the solution to a PH of 9.

I was sent a post saying to use AA instead of Bac water, mine tested at 2.92PH is this ok to use with NAD+?

 

[CNCCurrency]

I was sent a post saying to use AA instead of Bac water, mine tested at 2.92PH is this ok to use with NAD+?

It will burn, sting a bit. I would use it but add some bac to raise the level

 

[IronPaw.]

It will burn, sting a bit. I would use it but add some bac to raise the level

This what my friend sent me, it says that AA will help with the stability of NAD+. Do you know if it is accurate and will help preserve that potency of NAD+?

 

[tubby]

NAD+ is typically pretty acidic. I make my own and as long as the PH is 5 to 5.5 I have zero issues doing IM injections. One issue with NAD+ is basically the solution will crash quickly once over a PH of 5. At around PH of 7.5 it will be converted from NAD+ to the reduced form NADH. To give you an example of how quickly this can happen. .38 to .40 NaOH will get you to a PH of 5. Even just a single extra grain of NaOH will shoot the solution to a PH of 9.

Does that matter? Once injected into living tissue it's going to take on the pH of its environment very quickly. Bodies have natural buffers build it to keep pH in a fairly tight range, so regardless of what it enters at, it will be in a solution at whatever pH the body dictates in fairly short order.

To be clear I'm not suggesting you should inject something at either extreme on the pH scale unless you enjoy pain. Just pointing out that this is similar to eating a hot or cold item. Regardless of what temperature it went in your mouth at, it's going to hit your small intestine at body temperature.

 

[CNCCurrency]

This what my friend sent me, it says that AA will help with the stability of NAD+. Do you know if it is accurate and will help preserve that potency of NAD+?

I have always just used bac as the buffers keep it stable

 

[IronPaw.]

I have always just used bac as the buffers keep it stable

Ok my Bac tests at 4.90PH so it isn't very high anyway, might try using that in future......