Dosages and Reconstituting

[TheTinMan]

Hi all! I'm trying to navigate the peptide world and am just a few weeks into research. Is there any way I can have someone with a bit of experience, double check my "Dosage" columns? The BAC will vary being either 2 or 3mL. FWIW, these are not all being used at once. These are individual peptides that make up several cycles that I have planned. The plan is to titrate only when necessary.

Cycle Current cycle Dosage / Units - Dosage / mg Amount in Vial BAC to Reconstitute Injection site

Tesofensine
Month 1 - 0.5 tab - 250mcg 500 mcg / 100 tabs N/A Oral
Month 2 - 1 tab - 500 mcg / day
Month 3 - 1 tab - 500 mcg /day
Month 4 - 1 tab - 500 mcg / day

Retatrutide
Month 1 - 17-33 - 2-4 mg / week 24 mg 2mL Left arm
Month 2 - 50 - 6 mg / week
Month 3 - 75 - 9 mg / week
Month 4 - 100 - 12 mg / week

Cagrilintide
Month 1 - 10 - .25 mg / week 5 mg 2mL Right arm
Month 2 - 20 - .5 mg / week
Month 3 - 40 - 1 mg / week
Month 4 - 80 - 2 mg / week

SS-31
Month 1 - 20 - 2 mg / week day 30 mg 3mL Right arm
Month 2 - 40 - 4 mg / week day
Month 3 - 40 - 4 mg / week day
Month 4 - 40 - 4 mg / week day

MOTS-C
Month 1 - 40 - 2 mg / week day 10 mg 2mL Right arm
Month 2 - 100 - 5 mg / week day
Month 3 - 100 - 5 mg / week day
Month 4 - 100 - 5 mg / week day

Glow
Month 1 - 10 - 2.5 mg / .5 mg / .5 mg / week 50 mg / 10 mg / 10 mg 2mL Stomach
Month 2 - 10 - 2.5 mg / .5 mg / .5 mg / week
Month 3 - 10 - 2.5 mg / .5 mg / .5 mg / week
Month 4 - 10 - 2.5 mg / .5 mg / .5 mg / week

Semaglutide
Month 1 - 8 - .25 mg / week 10 mg 3mL Stomach
Month 2 - 15 - .5 mg / week
Month 3 - 30 - 1 mg / week
Month 4 - 51 - 1.7 mg / week
Month 5 - 72 - 2.4 mg / week

 

[dogmom]

Reta dosage look ok assuming you are using a 1.0 ml syringe. The ramp up on reta may be a little aggressive if you have not been on a glp before.

I've done Teso. Remember it has a 9 day half life. So it takes forever to get out of your system. I definitely would not recommend taking it daily. I took 125 mcg once to twice a week. But I tapered off of that now.

 

[FlowerFairy]

Hi all! I'm trying to navigate the peptide world and am just a few weeks into research. Is there any way I can have someone with a bit of experience, double check my "Dosage" columns? The BAC will vary being either 2 or 3mL. FWIW, these are not all being used at once. These are individual peptides that make up several cycles that I have planned. The plan is to titrate only when necessary.

Cycle Current cycle Dosage / Units - Dosage / mg Amount in Vial BAC to Reconstitute Injection site

Tesofensine
Month 1 - 0.5 tab - 250mcg 500 mcg / 100 tabs N/A Oral
Month 2 - 1 tab - 500 mcg / day
Month 3 - 1 tab - 500 mcg /day
Month 4 - 1 tab - 500 mcg / day

Retatrutide
Month 1 - 17-33 - 2-4 mg / week 24 mg 2mL Left arm
Month 2 - 50 - 6 mg / week
Month 3 - 75 - 9 mg / week
Month 4 - 100 - 12 mg / week

Cagrilintide
Month 1 - 10 - .25 mg / week 5 mg 2mL Right arm
Month 2 - 20 - .5 mg / week
Month 3 - 40 - 1 mg / week
Month 4 - 80 - 2 mg / week

SS-31
Month 1 - 20 - 2 mg / week day 30 mg 3mL Right arm
Month 2 - 40 - 4 mg / week day
Month 3 - 40 - 4 mg / week day
Month 4 - 40 - 4 mg / week day

MOTS-C
Month 1 - 40 - 2 mg / week day 10 mg 2mL Right arm
Month 2 - 100 - 5 mg / week day
Month 3 - 100 - 5 mg / week day
Month 4 - 100 - 5 mg / week day

Glow
Month 1 - 10 - 2.5 mg / .5 mg / .5 mg / week 50 mg / 10 mg / 10 mg 2mL Stomach
Month 2 - 10 - 2.5 mg / .5 mg / .5 mg / week
Month 3 - 10 - 2.5 mg / .5 mg / .5 mg / week
Month 4 - 10 - 2.5 mg / .5 mg / .5 mg / week

Semaglutide
Month 1 - 8 - .25 mg / week 10 mg 3mL Stomach
Month 2 - 15 - .5 mg / week
Month 3 - 30 - 1 mg / week
Month 4 - 51 - 1.7 mg / week
Month 5 - 72 - 2.4 mg / week

Peptide Calculator

Easy To Use Peptide Calculator by MEASUREPEPTIDES

measurepeptides.com

 

[TheTinMan]

Reta dosage look ok assuming you are using a 1.0 ml syringe. The ramp up on reta may be a little aggressive if you have not been on a glp before.

I've done Teso. Remember it has a 9 day half life. So it takes forever to get out of your system. I definitely would not recommend taking it daily. I took 125 mcg once to twice a week. But I tapered off of that now.

Thanks! I'm hoping there is minimal ramp-up. I'd like not have to titrate up to the higher dosages. It will only be as necessary.

 

[TheTinMan]

Peptide Calculator

Easy To Use Peptide Calculator by MEASUREPEPTIDES

measurepeptides.com

Thank you. I used a calculator, I just wanted to make sure I was using the recommended titrates.

 

[zpped]

You seem to have the math down but are missing the bigger concepts in a few places.

1) dose volume - you have lots of 100unit volumes. I think you'll find this fairly unpleasant. Ideally adjust your concentrations so your doses are between 20 and 50 units.

2) Tesofensine is way more of a take as needed/tolerable drug. Everyone is different but if I take it for more than 3 days I can't sleep properly anymore.

3) I'm particularly concerned with your incretin memetic strategy. There is no reason to plan out Sema/Cagri/Reta. Start Reta or Sema at the lowest dose (reta is better for nearly everyone if the cost difference doesn't matter) and then only titrate up if you haven't lost any weight for 2 months. If you reach the highest dose than consider adding a a little cagri to break the stall.

 

[Skidude]

You seem to have the math down but are missing the bigger concepts in a few places.

1) dose volume - you have lots of 100unit volumes. I think you'll find this fairly unpleasant. Ideally adjust your concentrations so your doses are between 20 and 50 units.

2) Tesofensine is way more of a take as needed/tolerable drug. Everyone is different but if I take it for more than 3 days I can't sleep properly anymore.

3) I'm particularly concerned with your incretin memetic strategy. There is no reason to plan out Sema/Cagri/Reta. Start Reta or Sema at the lowest dose (reta is better for nearly everyone if the cost difference doesn't matter) and then only titrate up if you haven't lost any weight for 2 months. If you reach the highest dose than consider adding a a little cagri to break the stall.

I started with 250mcg teso, titrated to 500mcg and went back to 250 shortly there after.
I then tapered off until i was at 125mcg every few days before stopping. that was 45 days ago and I am sure there is still some in my system, based on what others have posted and i have read.


After reading more about the meds I decided to titrate off and will only use as needed being certain not to combine with certain other meds.
Although I am not currently taking these other meds it seemed like a risk/reward scenario with the extreme half life and the minimal benefits. I did "feel" like it was helping with my process.

Tesofensine And Antidepressants (Zoloft, Prozac and Wellbutrin)

Find out more about the investigational weight loss drug tesofensine and whether it can be combined with antidepressants

medisearch.io

Indeed, Wellbutrin's effects are very similar to those of tesofensine, as it also inhibits the reuptake of monoamines like dopamine and norepinephrine. Theoretically, combining tesfonensine with antidepressants like SSRIs and SNRIs could have an additive effect on antidepressant response.

A critical difference between tesofensine and Wellbutrin, however, is that tesofensine also blocks serotonin reuptake. This increases the risk of serotonin syndrome, a toxic state caused by excess serotonin in the body manifested by shivering, rigidity, and even seizures. This must be considered when combining serotonergic drugs.

Combining tesofensine with dopaminergic antidepressants, such as Wellbutrin, is also risky. This is because excess stimulation of dopamine can be addictive, and you may develop a tolerance for these drugs, reducing their efficacy [12]. Excess norepinephrine stimulation can increase sympathetic tone, blood pressure, heart rate, and common side effects of taking tesofensine [13].

Therefore, the combination of tesofensine with any antidepressant should be approached with caution until more research is conducted.

 

[TheTinMan]

You seem to have the math down but are missing the bigger concepts in a few places.

1) dose volume - you have lots of 100unit volumes. I think you'll find this fairly unpleasant. Ideally adjust your concentrations so your doses are between 20 and 50 units.

2) Tesofensine is way more of a take as needed/tolerable drug. Everyone is different but if I take it for more than 3 days I can't sleep properly anymore.

3) I'm particularly concerned with your incretin memetic strategy. There is no reason to plan out Sema/Cagri/Reta. Start Reta or Sema at the lowest dose (reta is better for nearly everyone if the cost difference doesn't matter) and then only titrate up if you haven't lost any weight for 2 months. If you reach the highest dose than consider adding a a little cagri to break the stall.

Thanks for the feedback!

On the dosage volume, what are the unpleasantries related to using more units at a lower concentration? To the contrast, are there any benefits to using a higher concentration? Please excuse my ignorance.

I like your approach on the Teso. I'm going to adjust frequency to M,W,F @250mcg.

I definitely had to google incretin memetic strategy. The Sema is the only one I do not plan to take myself. I just wanted to double check dosages before helping a relative with it. It would only be Reta/Cagri on my stack, but I plan to lag a month or two on the Cagri portion of the stack. I didn't want to start two at the same time because I wouldn't be able to discern the individual impact between the two.

 

[Morbius]

On the dosage volume, what are the unpleasantries related to using more units at a lower concentration?

Bigger shots hurt more than smaller shots.