Hello! Hope I am doing this right...

[bean10]

New here, and pretty new to peptides. I have a lot to learn! Have had great success with BPC so far. Looking to start GLP1, just waiting on my order to arrive. Have been doing lots of research on the metabolic benefits... and of course wouldn't complain about weight loss too! I must admit I'm feeling pretty intimidated and overwhelmed by this forum, but it seems there are some pretty smart people here. Any advice for a newbie on navigating the forum? I am specifically looking for info on microdosing GLP1 and managing dosing schedules, like what seems to work for people for increases/decreases etc, but haven't been finding much. I'm from Canada and I can find next to nothing in terms of health providers who believe in the benefits of GLP1s and peptides, so here I am hoping I can learn from all the experts here.

 

[Skidude]

You are doing just fine!
If you want to do fantastic here is a few hints:

You are on your way, it is always good to ask for people to help elaborate or distinguish between options as opposed to questions without any content showing you have made effort.

So i might ask chatgpt about micro dosing GLP1
This is the result, I would read it and decide what i was curious about-
I would then maybe post in the Tirz or Sema forum on the main page a question.

Title- Do you Micro dose and is it working?
Body, I feel like there are benefits that I am interested in like: X,Y,Z
What have you experienced?
At that point you can engage with those interested as well and be an active participant in the conversation. GOOD LUCK! 🙂

Microdosing GLP-1 receptor agonists like tirzepatide, semaglutide, or liraglutide is an emerging off-label approach some people explore to minimize side effects (like nausea) while still aiming for metabolic, cognitive, or weight-related benefits. Here’s a breakdown:

---

🧪 Microdosing GLP-1: Overview​

Definition: Using a fraction of the standard clinical dose (e.g., 1/10th to 1/4th) more frequently or at lower single doses to modulate insulin, hunger, and inflammation without full therapeutic intensity.

---

💡 Why Microdose GLP-1?​

Benefit	Explanation
Reduced side effects	Lower incidence of nausea, vomiting, or fatigue
Cognitive & neuroprotective interest	Potential benefit without aggressive appetite suppression
Mood balance	Anecdotal and early research suggest GLP-1s may help mood and anxiety—lower doses may support this without over-suppressing appetite
Better titration	Easier to personalize for weight maintenance or glucose stability
Longer tolerability	Easier to stay consistent with minimal discomfort

---

🧬 Example Microdosing Protocol (Tirzepatide)​

Week	Dose	Notes
1–2	1.0–2.5 mg once weekly	Optional: split in half twice per week (e.g., Wed/Sat)
3–4	2.5–5 mg once weekly	If tolerated, you can go up slightly
5+	Stay at 5 mg or adjust	Often no need to go to 10–15mg unless for full therapeutic use

• Split dosing idea: e.g., 2.5mg on Wednesday, 2.5mg on Saturday for a “gentler” curve
• Combine with mitochondrial support (like your current SS-31/MOTS-c) for synergy

---

⚠️ Considerations​

• Microdosing is not FDA-approved, and studies on sub-therapeutic GLP-1 dosing are limited.
• Lower doses may not induce the same appetite suppression or weight loss as full doses.
• Blood sugar levels and energy may still be positively affected.
• Always start under supervision if possible—especially with existing metabolic or GI conditions.

 

[bean10]

You are doing just fine!
If you want to do fantastic here is a few hints:

You are on your way, it is always good to ask for people to help elaborate or distinguish between options as opposed to questions without any content showing you have made effort.

So i might ask chatgpt about micro dosing GLP1
This is the result, I would read it and decide what i was curious about-
I would then maybe post in the Tirz or Sema forum on the main page a question.

Title- Do you Micro dose and is it working?
Body, I feel like there are benefits that I am interested in like: X,Y,Z
What have you experienced?
At that point you can engage with those interested as well and be an active participant in the conversation. GOOD LUCK! 🙂

Microdosing GLP-1 receptor agonists like tirzepatide, semaglutide, or liraglutide is an emerging off-label approach some people explore to minimize side effects (like nausea) while still aiming for metabolic, cognitive, or weight-related benefits. Here’s a breakdown:

---

🧪 Microdosing GLP-1: Overview​

Definition: Using a fraction of the standard clinical dose (e.g., 1/10th to 1/4th) more frequently or at lower single doses to modulate insulin, hunger, and inflammation without full therapeutic intensity.

---

💡 Why Microdose GLP-1?​

Benefit	Explanation
Reduced side effects	Lower incidence of nausea, vomiting, or fatigue
Cognitive & neuroprotective interest	Potential benefit without aggressive appetite suppression
Mood balance	Anecdotal and early research suggest GLP-1s may help mood and anxiety—lower doses may support this without over-suppressing appetite
Better titration	Easier to personalize for weight maintenance or glucose stability
Longer tolerability	Easier to stay consistent with minimal discomfort

---

🧬 Example Microdosing Protocol (Tirzepatide)​

Week	Dose	Notes
1–2	1.0–2.5 mg once weekly	Optional: split in half twice per week (e.g., Wed/Sat)
3–4	2.5–5 mg once weekly	If tolerated, you can go up slightly
5+	Stay at 5 mg or adjust	Often no need to go to 10–15mg unless for full therapeutic use

• Split dosing idea: e.g., 2.5mg on Wednesday, 2.5mg on Saturday for a “gentler” curve
• Combine with mitochondrial support (like your current SS-31/MOTS-c) for synergy

---

⚠️ Considerations​

• Microdosing is not FDA-approved, and studies on sub-therapeutic GLP-1 dosing are limited.
• Lower doses may not induce the same appetite suppression or weight loss as full doses.
• Blood sugar levels and energy may still be positively affected.
• Always start under supervision if possible—especially with existing metabolic or GI conditions.

Thanks so much for your help!

 

[Calm Logic]

I am specifically looking for info on microdosing GLP1

It's not surprising you didn't find much since there is more experience with macro-dosing 🙂 The micro-dosing is usually as part of a stack with something else.

 

[Calm Logic]

Looking to start GLP1, just waiting on my order to arrive

Which GLP did you get?

 

[Calm Logic]

• Combine with mitochondrial support (like your current SS-31/MOTS-c) for synergy

That's interesting:

Potential Synergistic Effects:

The synergy between these three agents could stem from their complementary actions on metabolism, cellular energy, and overall health:

1. Enhanced Metabolic Regulation:
   • Tirzepatide directly impacts glucose and lipid metabolism through GLP-1 and GIP agonism, leading to better blood sugar control and weight loss.
     
     
   • MOTS-c further supports metabolic health by activating AMPK, improving insulin sensitivity, and enhancing glucose and fat metabolism at a cellular level. This could amplify the benefits of tirzepatide in addressing insulin resistance and promoting weight loss.
     
     
   • SS-31, by ensuring healthy mitochondrial function, provides the cellular energy necessary for efficient metabolic processes, making the body more responsive to the metabolic signals from tirzepatide and MOTS-c.
2. Mitochondrial Optimization and Cellular Health:
   • SS-31 acts as a foundational support, protecting existing mitochondria from damage and improving their immediate function. This creates a healthier cellular environment.
     
     
   • MOTS-c then builds upon this by promoting mitochondrial biogenesis (creating new, healthy mitochondria) and optimizing their performance. This could lead to a more robust and efficient cellular energy system.
     
     
   • Tirzepatide, while not directly a mitochondrial peptide, improves metabolic conditions (like reducing hyperglycemia and inflammation) that can negatively impact mitochondrial health. By alleviating these stressors, tirzepatide creates a more favorable environment for SS-31 and MOTS-c to exert their effects.
3. Reduced Oxidative Stress and Inflammation:
   • Chronic metabolic dysfunction, often targeted by tirzepatide, is associated with increased oxidative stress and inflammation.
     
     
   • SS-31 directly combats oxidative stress at the mitochondrial level, reducing cellular damage.
     
     
   • MOTS-c has anti-inflammatory properties and helps cells adapt to stress.
     
     
   • This combined anti-inflammatory and antioxidant effect could mitigate the cellular damage often seen in conditions like type 2 diabetes and obesity, potentially leading to better long-term outcomes and fewer complications.
4. Improved Energy and Vitality:
   • By enhancing mitochondrial function (SS-31, MOTS-c) and optimizing energy metabolism (all three), the combination could lead to significant improvements in overall energy levels, physical performance, and reduction in fatigue often associated with metabolic disorders.

Important Considerations:

It is crucial to note that while these theoretical synergies are plausible based on current understanding of their individual mechanisms, there is currently limited to no published clinical research specifically investigating the combined use of SS-31, MOTS-c, and tirzepatide.

• Clinical Evidence: Most information regarding SS-31 and MOTS-c as therapeutic peptides is from preclinical studies or early-stage human trials, often in the context of functional medicine or anti-aging clinics. Tirzepatide, conversely, is a well-established pharmaceutical with extensive clinical trial data.
  
  
• Regulatory Status: Tirzepatide is an FDA-approved medication. SS-31 (Elamipretide) has been studied in clinical trials for various conditions but is not yet FDA-approved for general use. MOTS-c is largely considered a research peptide.
  
  
• Safety and Dosing: Combining agents with different mechanisms of action always requires careful consideration of potential interactions, side effects, and appropriate dosing. Without specific research, such combinations should be approached with extreme caution and under the guidance of a highly knowledgeable healthcare professional, if at all.

In summary, the theoretical synergy between SS-31, MOTS-c, and tirzepatide lies in their complementary roles in improving metabolic health, optimizing mitochondrial function, reducing cellular stress, and enhancing overall vitality. However, the lack of clinical data on their combined use means that any real-world application of such a combination would be experimental and requires significant further research.

 

[Skidude]

That's interesting:

Yeah, I do feel like a lab rat sometimes, but when i did my first cycle of SS-31/MOTS/ w/NAD I was hoping for optimization of all future peps.

As you said in a previous post w/o telomere measurement or acid test I will never know- but anecdotally my calories are rising as is my energy and I have lost or gained no more than a pound since hitting goal 2.5 months ago, and am currently 1lb under goal after increasing from 1200 to 1900 calories and not eating quite as clean. Only time will tell, I have 2 more weeks on this cycle and just on Mots now 3x per week at 5mg