On max dose of sema

[Mle2520]

I’ve been on 2.4mg semaglutide for 2.5 months and have been stalled for a month or so and food noise is coming back a bit. Obviously the next step would be switching to another med, right? The only thing Is I have a stash of a few more months worth of sema. Wondering if anyone has injected the max dose like every 5 or 6 days?

 

[AndyPanda]

There are trials of Semaglutide up to 7mg. I know for a fact people on here and MESO have gone above 2.4mg. Really, with gray market overfill, most people on max dose Semaglutide have likely gone over. I would say bumping it up to 3mg or 3.5mg would be the easiest and most economical course of action.

You could switch to Tirzepatide but you would need to start low and titrate up to find the sweet spot, taking time. You could also add Cagri or switch to Retatrutide, but those are not even out of trials and are more experimental than just upping the Semaglutide dose.

Other option would be to take a break from all of it and give your receptors time to refresh and then start over?

 

[Calm Logic]

Other option would be to take a break from all of it and give your receptors time to refresh and then start over?

Oh god no. That is a recipe for weight gain unless you are particularly motivated and unstressed and all of your chakras are in alignment 😀

 

[AndyPanda]

Oh god no. That is a recipe for weight gain unless you are particularly motivated and unstressed and all of your chakras are in alignment 😀

A good test to see if we learn anything and make good changes. We are all going to lose access to these drugs eventually.

 

[Calm Logic]

A good test to see if we learn anything

When I paid $550 for my first vial of tirz, that changed a lot of priorities right there.

So even at the start, I learned to throw away food despite being cheap, and to not buy any food that was too addictive.

And these injections, as I said before, help to undo years of learned hopelessness. You can't put a price on hope.

 

[Bflo_Bflo_Bflo_Bfl]

There’s a trial of sema up to 7.2. It’s not published yet but you should be able to find some info including a table of adverse events (AEs) by dose. Look for semaglutide step-up trial. It ran its full course, and if there had been a ton of AEs they would have pulled the plug early.

I’m at 3.6 myself. Well, as close as I can get using a 1 ml syringe to measure my BAC and sema.

 

[zpped]

We will all going to lose access to these drugs eventually.

Sema is going generic in Canada next year. I have enough tirz and reta to last me until they go generic in the US.

 

[MsGizmo]

A good test to see if we learn anything and make good changes. We will all going to lose access to these drugs eventually.

If anyone does this I would recommend a slow withdrawal instead of abruptly quitting.
--> study on slow sema withdrawal <--

 

[beingthere]

I would suggest going to 6 then 5 days frequency if you have minimal side effects. If everything looks good after a month but you still have food noise, you might want to try the 2 times/week approach but halve the dosage or just a bit more. So if you are at 2.4mg, if ypu switch to 2 times/week pinning, I would go 1.2-1.4mg max
There is also the switching compound approach, or you could add minimum dose of other compound to your protocol see how you respond and according to that increase the second compound while decreasing the 1st. That would allow for an easy transition from one compound to the other
Third option, the harshest, stop cold turkey for 2 weeks then start again at half dose and see how it goes
To be honest, I think the tapering off sema combined with gradually increasing a second compound (tirzepatide) would be the way to go if you are not responsive after 1.5 months at 2.4mg. And increases with tirz, i would go 10% weekly not doubling every 4 weeks as is stated in the proospect