Retatrutide Journey Pre to Post

[desinr-gal]

Theres also no reason to think Reta will stop working, as the body doesnt seem to deal with as much receptor desensitization.

Something I commonly see with GLPs is the idea that you need to be on them forever.

I know people have results they never dreamed of on them - but thats not right. your body not being able to lose weight is either caused by you eating like an asshole and having no self control(which is fixable) OR its because something is wrong with your body and theres a 90% chance there is medication that can fix your body so you dont need the GLP forever.

hormonal issues or metabolic ones have adverse effects on your body besides making weight loss difficult, its better to figure out some of those issues with a doctor so you dont have long term complications OR get tied to being on a GLP forever.

Ahem.. problems with women's hormones later in life are not easily resolved. Yes there's HRT but very few docs want to deal with it, it changes throughout the day, week etc. so not easily determined there are many kinds to track and the whole body is in a changing situation with many complexities. Your exprssed viewpoint is blind and dismissive, not to mention insulting.

 

[Incognitodoberman]

Please point to what you've been reading that says this. Every expert I've spoken too all agree that this is just uneducated speculation by people that don't know what they are talking about.

I spent way too much time trying to find the article I read last night about the potential effects of going backwards from a triple agonist to a dual or single — and I still can't find it, but I know I read it. Along the way, I ran into a few AI-generated summaries, but I don’t really consider those solid sources. That said, I did end up reading quite a few other articles and studies during the search.

The article that I read last night didn’t claim this happens to everyone, but it did say that switching from a high dose of something like Reta to a dual or single could possibly affect how much stimulation a person receives. It was framed more as a potential effect than a guaranteed outcome. I also talked to someone who went through this kind of transition himself, and his experience lined up with what the article suggested — so to me, that reinforces the idea that it’s at least possible.

If I’m remembering right, I also saw something about Phase 2 trial results where subjects were monitored to see if they'd plateau at high doses, and after 48 weeks, they did not. That's reassuring. Since Reta is now in its final trial phase, I’m really curious to see what kind of data comes out from the trial as it started back in 2023.

 

[zpped]

What would be the purpose of switching off of reta though? Reaching a plateau on reta, you're not going to lose more on tirz because you've already lost more than tirz is capable of giving you.

 

[Incognitodoberman]

What would be the purpose of switching off of reta though? Reaching a plateau on reta, you're not going to lose more on tirz because you've already lost more than tirz is capable of giving you.

I don’t know that I can answer that 100%, but I do feel I can trust in the information I’ve received. It made me second guess myself in that I’m going about things the wrong way (beginning with Reta). I can say this information came from a credible source, not something wonky like Reddit.

My challenge is that I can spend months researching and learning and still end up with conflicting opinions. Feels like a game of tug-of-war and trying to decide which team to stand with, even though both sides provide valid arguments. I guess that’s where personal experiences can add a layer of clarity that the data alone doesn’t always provide.

At this point, I’m still not entirely sure which direction to go. Since I don’t have Tirzepatide in hand yet, I do have some time to keep researching and figuring things out. Oddly enough, I had a dream last night that some friends wanted vials of Tirzepatide, and I ended up selling them all for $100 each. Maybe that’s a sign, but either way, I’m still giving myself time to decide.

 

[spyke65]

From what I’ve been reading, as well as speaking with someone who has gone through this personally, it is possible that if you start with the most powerful option (triple agonist) and later a dual or single agonist, your body may adapt to all three pathways, so moving down to a dual or single agonist may be less effective.

Theoretically Retatrutide is “the most powerful” option, but not necessarily. Your needs today could be vastly different than your needs months or years down the road when Retatrutide stops working for you. Your body may need the glucagon agonist the most right now but as you near your goal weight and maintenance, you may only need the GLP-1 agonist. Or you may need to add an amylin agonist to the mix.

Also, some food for thought, Retatrutide isn’t on the market yet and there are quadruple incretin agonists coming through the research pipeline right behind it. In particular, NA-931 (bioglutide) seems to have a lot of promise.

My personal justification for going from Semaglutide to Retatrutide is the same as why if I’m buying a new computer, I go for the best model I can afford. New technology will follow over time so I’ll take the benefits of the new technology until it no longer works then pick the next better that comes along.

 

[Incognitodoberman]

Theoretically Retatrutide is “the most powerful” option, but not necessarily. Your needs today could be vastly different than your needs months or years down the road when Retatrutide stops working for you. Your body may need the glucagon agonist the most right now but as you near your goal weight and maintenance, you may only need the GLP-1 agonist. Or you may need to add an amylin agonist to the mix.

Also, some food for thought, Retatrutide isn’t on the market yet and there are quadruple incretin agonists coming through the research pipeline right behind it. In particular, NA-931 (bioglutide) seems to have a lot of promise.

My personal justification for going from Semaglutide to Retatrutide is the same as why if I’m buying a new computer, I go for the best model I can afford. New technology will follow over time so I’ll take the benefits of the new technology until it no longer works then pick the next better that comes along.

I really appreciate this feedback; it’s very helpful. I’ve started to see some early information on the quadruple, though I haven’t explored it in depth yet, I imagine it will become the next highly sought-after GLP. The science behind these developments is incredible on so many levels. While working alongside researchers, in an entirely different field, I find it fascinating to follow the evolution of their work and see how consistently life-changing it continues to be.

 

[PackmanJohnny]

That is contrary to what actual doctors who have spent their lives studying the issue are saying. I read just the other day that there are at least 14 different genetic markers that contribute to obesity. While I don't know exactly how many different medical conditions contribute to obesity here are just a few of them: hypothyroidism, Cushing's syndrome, Polycystic Ovarian Syndrome (PCOS), Prader-Willi syndrome, and certain hypothalamic issues. Medications used to treat other conditions, such as certain antidepressants, steroids, antipsychotics, and hormonal birth control, can also lead to weight gain and obesity. I find it strange that you mention "medications" that can "fix our bodies" in the same sentence as you saying we won't need GLP-1 drugs for life .. so which is it? Do we need medicine or not?

The main difference is that the condition CAUSING the obesity is not being treated by the GLP-1. You also have to factor in what other damage that condition is causing your body that you are no longer attempting to treat because the most noticeable part (obesity) is no longer bothering you. Hypothyroidism, for example(which I am diagnosed with) can lead to Peripheral neuropathy, Cognitive issues, as well as endocrinal and reproductive disorders that are unrelated to the likely obesity-related issues like hypertension. When you take the GLP and lose the weight, you still have hypothyroidism and still carry the risk for the other negatives regarding that condition, where if you properly work out the needed medicinal treatment for your thyroid, you would more than likely not need the GLP and be able to lose weight with diet and exercise, and maintain that weight loss with good habits.

The GLP might be great at helping you relieve one issue in your body, but you may be doing yourself a disservice in the long run by not caring for the root cause.

BUT - ALLLLL of that applies to a rather small part of the population. The majority of overweight and obese people in America and other places are not obese because of a medical problem, theyre obese because they do not care for their bodies or have good habits, and being on a GLP for life because youre incapable of not eating cake is weak sauce. not ascribing that to anyone here, thats just my opinion of the general masses.

 

[PackmanJohnny]

Ahem.. problems with women's hormones later in life are not easily resolved. Yes there's HRT but very few docs want to deal with it, it changes throughout the day, week etc. so not easily determined there are many kinds to track and the whole body is in a changing situation with many complexities. Your exprssed viewpoint is blind and dismissive, not to mention insulting.

If your doctor 'doesnt want to deal with' your health, thats a shit doctor. I know healthcare is expensive and finding a good doctor can be hard, but that is not a good reason to dismiss HRT. My mother happens to be about 6 months into it now and she is having some fantastic benefits, both on the scale and in her energy levels, hair thickness, etc.

I'm really not sure whats insulting about urging people to be actually aware of their health. with the body as complex as you're saying, shouldn't we do as much as we can to be as healthy as possible? GLPs are wonderful tools, but they arent magical. If Im blind and dismissive for urging people to monitor their health and try treating actual conditions vs blindly relying on experimental drugs, so be it I guess lol.