Have you stopped taking your GLP, and if so what happened?

[Longstory]

My brother is one of those who has permanent vision loss in one eye, apparently due to sema, so he has been off since June and won't ever take it again since he doesn't want to risk losing vision in both eyes.

Since coming off in June he has gained back 20 pounds. He says he is eating the same as when he was on sema. I'm a little skeptical of that, but I don't see him much so I don't know. So now he's feeling crappy and depressed. He's going to start working out more to see if that combats the gain.

Skeptics my entire life have told me calories in calories out… it’s as simple as that. If that was true then I wouldn’t have needed this medication at all. There’s a lot of research out there to prove that it works to combat insulin resistance amongst other things. It can also change the composition of fibrotic fat seen in lipedema patients.

There is much more research needed to understand all the mechanisms of Glp1’s and the effects on the body.

I’m living proof that calorie intake and calorie expenditure and a calorie deficit- doesn’t always equal weight loss.

 

[cookieguggleman]

I’m in overeaters anonymous which has been a life changer for my BED and bulimia. I want the sanity and the vanity. Tirz is just one of many tools I use, I can’t rely on it 100%

 

[keangkong]

My brother is one of those who has permanent vision loss in one eye, apparently due to sema, so he has been off since June and won't ever take it again since he doesn't want to risk losing vision in both eyes.

Since coming off in June he has gained back 20 pounds. He says he is eating the same as when he was on sema. I'm a little skeptical of that, but I don't see him much so I don't know. So now he's feeling crappy and depressed. He's going to start working out more to see if that combats the gain.

Calories in, calories out. That has turned out to be basically accurate, according to numerous nutritional studies, although nutritionists can tell you a million ways that you may be influencing calories out that were not aware of.

Tirzepatide has been tested to see if it increases metabolism. Tirzepatide has little effect on overall metabolism.

People are poor historians of their dietary habits. (I exempt serious body builders from that generality. They have to be precise in what they eat since they're constantly intentionally going up or down in weight.) I believe it feels like he's eating the same amount of food. He's being a normal human by thinking so.

I recently had to stop retatrutide due to possible liver problems. I'll likely start again soon. On the tirzepatide alone, I don't feel like I'm eating too much. However, my weight keeps increasing. The FEELZ test for how much we're eating is usually a poor indicator. Keeping dietary records, is strictly followed and accurately done, reveals valuable information but it's unusual for a person to consistently and strictly track all food and exercise.

Apparently, reta causes a slight increase in metabolism. Mazdutide also causes an increase in metabolism.

 

[Longstory]

Calories in, calories out. That has turned out to be basically accurate, according to numerous nutritional studies, although nutritionists can tell you a million ways that you may be influencing calories out that were not aware of.

Tirzepatide has been tested to see if it increases metabolism. Tirzepatide has little effect on overall metabolism.

People are poor historians of their dietary habits. (I exempt serious body builders from that generality. They have to be precise in what they eat since they're constantly intentionally going up or down in weight.) I believe it feels like he's eating the same amount of food. He's being a normal human by thinking so.

I recently had to stop retatrutide due to possible liver problems. I'll likely start again soon. On the tirzepatide alone, I don't feel like I'm eating too much. However, my weight keeps increasing. The FEELZ test for how much we're eating is usually a poor indicator. Keeping dietary records, is strictly followed and accurately done, reveals valuable information but it's unusual for a person to consistently and strictly track all food and exercise.

Apparently, reta causes a slight increase in metabolism. Mazdutide also causes an increase in metabolism.

I’ve been keeping strict diet diaries. Not just for myself, but for my daughter who’s part of an NHS programme that requires it. I’ve worked with the dieticians, nutritionists and a speciality endocrinologist nurse and consultant for the past 2 years. They are doing research into genetic obesity with genetic testing involved. My body composition at the moment says that I should be able to consume 1600cals and maintain. However, after many months we’ve found out that that’s not the case. It can be due to many factors but the likely cause is predisposition of fat accumulation and a mixture of lipedema and pcos.

Of course that doesn’t even take into account the amount of aerobic activity and core training that I do, in theory I should be able to eat more and not gain- however, again, the theory was wrong.

Working with the team we hope to shed more light on genetic obesity and isolate the genes involved. It’s eye opening for sure.

I do know that nearly all patients have a period of weight gain after stopping Glp1’s. Some were diet related- but not all.

 

[psycho_driver]

My brother is one of those who has permanent vision loss in one eye, apparently due to sema, so he has been off since June and won't ever take it again since he doesn't want to risk losing vision in both eyes.

If you don't mind my asking a few questions I'm really curious about these cases.

Is he diabetic, pre-diabetic or neither as far as you know?

Was he losing at a healthy 1-2lbs/wk or was it more?

Do you feel there were any other factors that could have contributed to the vision loss outside of GLP-1 use?

 

[keangkong]

I’m in overeaters anonymous which has been a life changer for my BED and bulimia. I want the sanity and the vanity. Tirz is just one of many tools I use, I can’t rely on it 100%

Fortunately, tirzepatide is around to help people. Often, however, more needs to be done.