That's UACR. It stands for urine albumin-to-creatinine ratio. It's a test that measures the amount of albumin and creatinine in a urine sample to help detect early kidney damage. It's measures in mg. They measured UACR at baseline and the study participants needed to have a UACR ≥ 30 mg/g (a threshold often used clinically to indicate micro- or higher albuminuria, a sign of kidney stress/damage) and/or people with reduced baseline eGFR. and again at the end of treatment (week 40 or 42, depending on the subtrial).
They looked at Tirz at 5mg, 10mg and 15 mg and by measuring before and after...... They could estimate how much of the UACR reduction might be due to changes in glycemic control (HbA1c) and weight loss — and how much might be “direct” effects (or due to other factors) associated with tirzepatide.
They looked at Tirz at 5mg, 10mg and 15 mg and by measuring before and after...... They could estimate how much of the UACR reduction might be due to changes in glycemic control (HbA1c) and weight loss — and how much might be “direct” effects (or due to other factors) associated with tirzepatide.