Search results for query: reta transition

It's part of the calculation I'm doing in my head for when I reach goal weight. It's not so much a switch as it is an addition, as I titrate down on Reta. I'm one of the responders that gets almost complete appetite suppression from Reta and I want to maintain that. So as I titrate Reta...

Years of dry, flaking patches, often red and inflamed w/ some bleeding, for years( becoming worse during peri- menopause and Menopause). Dermatologist just prescribed tar shampoos, creams, but issue still remained, and she didn't have a clear answer for me, but always stated " its not eczema...

Starting my transition since the last week from January Titrating up Reta slowly but even with this small dose (now 0.35mg every two days) I'm already "feeling" Tirz was working.. But I started to feel very fatigue and depressed.. Now I'm better

I think if someone brand new to GLPs and just starting with Reta, like it sounds the OP is, therapeutic levels and steady state are pretty close together. I felt my first 1 mg dose later the same day. Each week just reinforced the effects I felt that first day, so going by "feels" it felt...

It takes ~4 weeks to reach steady state for a given dose. Steady state is not the same as therapeutic levels. I switched from Tirz to Reta for the GCGR signaling. Therapeutic levels for that to be reliably signaled are thought to be ~6-8mg/week, which is 7.5-10mg average exposure at steady...

In the same boat. I’ve been doing 5mg tirz every 7 days in hopes of maintaining but now think I’m going to stick with same dose but shorten it to every 5 or 6 days instead of 7. Stupid food noise and cravings are very distracting!

That's where I am to when I started on Tirz I didn't even have a scale in the house (to depressing to even step on one). Six weeks latter I'm wearing jeans I had packed a way two years ago that I could not fit in to and I'm wearing a coat that I previously couldn't zip up. I'm so happy with the...

I run Reta 4 mg every 84 hours. The last 12ish hours get tough with hunger for me. Definitely less hunger suppression than on Tirz, BUT, high dose Tirz was hell for me. I struggled to function for about 72 hours after that injection. I felt like I got ran over by a truck. Plus hit an extended...

I switched cold turkey. Thinking about adding 3mg of tirz this afternoon and seeing how I feel with that. I think that makes the most sense transition down with one and up with another.

There is a viewpoint that you could escalate reta dosage to get in the gcgr signaling range for the metabolic and lean mass preservation benefits over Tirz. I prescribed to that idea with my transition from tirz to reta. Appetite control and noise suppression isn’t a problem for me on reta.

I'd think tapering makes it easier to manage symptoms. I was only at ~5.5mg Tirz peak and not steady state. I started taking small doses of Reta frequently to test for sides. Since starting the transition I've taken two Tirz injections peaking at 4.5mg and 3.5mg respectively, each a week...

I am at 4mg but stalled the past week+ and gained about 2 pounds. I will go to 5mg next dose. I am hoping not to eventually go above 6mg. I've read of several members who've had success stacking Reta and Sema. I think I will go that route at some point in February.

Watching his video here, mainly the part on split dosing this time, I've watched the video before. Split dosing dose not affect your average exposure, but it absolutely suppresses peaks and raises troughs. I posted about the math here showing average exposure is the same, but peaks and troughs...

This app looks great! Thank you for explaining the peaks and troughs a bit better for me. Definitely makes it easier to mitigate the side effects and understand what I’m aiming for. Split dosing seems to be the way to go from everything I’ve read. I’ll have to start playing around with it. Thank...

I’m bridging from Tirz to Reta. I use Shotsy (app) and a spreadsheet to track things. For the transition I have gone with the more frequent smaller doses and so far everything is moving well with no to minimal side effects. Steadier state makes more sense to me with GLP, weekly pulses drop...

I had been on Tirz for close to 2 years before switching to Reta. I was on 15mg for many many months. I have now been on Reta for a few months. Maybe around 3 months. I am getting the same affects with only being on 2mg of Reta each week. Things are going great!

I haven't seen you posting in a minute! Hiya! Been in maintenance since May 2025. Posted the following some where before..... I dont think it meets your specific data need as i didn't switch to a Reta high dose, but did not wash out and pretty much went off Tirz cold. "On Tirz exactly 1 year...

I did! Triz for a year and a month at the highest dose. The hunger is frustrating at first. And also a bit like “is this stuff working” I’ve optd to stack, delivery today. I am in love with Triz noise elimination, I also enjoy the nausea sides of Triz. But once you work thru the titration...

I was on high tirz and freezing all the time, and stalled, so I started with very low dose Reta and slowly decreased my tirz and increased my Reta. I was off tirz completely, but decided to add it back in because my arthritis returned. Currently stack 2.5 tirz with my 8 or 10 Reta and a low dose...

So, you need 30mg of MOTS-Ç weekly? I see some vendors have 40mg vials. Just wanted to make sure I was looking at it correctly.

Interesting.

Here’s another report of cold turkey transition from Tirz 15mg to Reta. It inspired me to switch my MOTS-C to 10mg M/W/F. View: https://www.reddit.com/r/BodyHackGuide/comments/1ldz8kh/preventing_the_ozmpic_skinny_look_how_retatrutide/

Good to hear. I think I'm going to speed up my transition from 15 mg of tirzepatide to retatrutide.

Hey everyone, So I have a question. I have begun reading up on Ret. I am currently on Tirz. Just started 3 weeks ago. I was interested in transitioning to Ret. So far, I see people transition at higher doses. I wanted to give Tirz a chance for a while, but if I were to transition now. How...

Yeah, exactly. I think 9 mg could be a rough ride for newbies. I am glad I am home for the holidays on this pill, as in close to a bathroom. If one is prone to diarrhea on GLPs like me, this one seems no different in that regard (no better or worse). For newbies, I still think orfo may be...

Totally fair and great questions. The main reason I’m starting with Tirz first is simply that I’m brand new to GLP-1s. It feels like a more tried and true entry point for me to understand how my body responds before moving into something stronger. I want to learn my tolerance, appetite...

I love a good plan, just wondering why start with Tirz and then Reta? I get that most people who transition to grey move to Reta. I also when people (friends and family) want to get started I don't reccomend Reta only because I consider Tirz a more "proven" drug with way more data behind it...

I'd be interested in the logical progression it went through to reach that conclusion, as it seems faulty, although I certainly could be mistaken too. The glucagon-agonist in reta is increasing glucagon signaling at receptors (making your body think there's tons of glucagon, when in reality...

I'll be generous of spirit and just assume emotional reactiveness is a side effect of whatever protocol you're on. I told you I appreciated the education on the auto injector pen splitting. And I meant it. But proffering a suggestion doesn't obligate the questioner to adopt it. I've weighed the...

You could recon your pens into vials and draw from that. Many people do that to adjust doses.

I see. In my case my sema is the official Wegovy and I can't adjust its dose. It's an all or nothing style pen, so I wouldn't be able to follow that type of transition protocol that would work for those transitioning From a vial-based sema to a vial-based Reta. I think I'll start week of Reta...

From Gemini:

Transition usually involves stacking during the period of transition.

I'm a longtime weekly sema (Wegovy) user -- for about 18 mos. I take it primarily for insulin resistance -- and it's been great in that regard. Unlike most folks with GLPs, I don't seek major appetite suppression. Been at a weekly maintenance dose of 1mg/week for a year. Insurance is no longer...

With the excitement around Reta's phase 3 trial results being shared, I'm sure there are more people now than ever contemplating making the switch from Tirz to Reta. And while I've read quite a few posts from people who are either stacking both with each other or other peps, or switched from...

The funny thing is that the reduction of appetite, AKA "food noise" could easily go unnoticed except for the fact that many of us that desire to lose weight have become hyper focused on our eating due to many past attempts of trying to lose weight through dieting. The use of GLP1s have made...

Thanks for feedback

I’d stick with tirz and slowly add Reta while leaving the tirz dose the same. I’m trying to avoid having you regain wait during a transition from tirz to Reta.

I stopped testing brand sema for 2 months. Started again at lowest dose. Titrated up to 1.7. it's as if I'm testing water. Titrating up to 2.4 on Wednesday. After that, I don't know what to do. I have a lot of sema; had to make it worth the shipping fee. Tirz? Reta? Stay with Sema and add Cagri?

When this happened to me, I took a 3 week break and it worked. Went from being on 15mg Tirz every 5 days to only needing 10mg. However, it didn't last as long and I was needing to titrate back up fairly quickly. I'm back up on the highest dose, though I'm currently splitting it so I stead of...

Is there a reason that you're not waiting to see if a higher dose of tirz will work better?

Well this was an impactful thread. I am about to start my second dose 10.0 of tirz. It's been a bit of a surprising last 4 weeks for me. So, I was a sema non-responder. Food noise was much quieter, and I was not completely unhappy, but my insurance was pushing for results or cancel of coverage...

you need to add vegetables and fruits and legumes to that. They have the fiber, water, and important nutrients to fuel you and help maintain your body. Plus they are low calorie and filling

I am starting week 4 of a 6 day weekly routine with Sunday’s off. Push/pull/legs/push/pull/legs. I have been fairly lazy with nutrition up to this point, and I still have 35lbs+ to lose. I have been simply working from a calorie deficit with a lot of protein drinks and bars, filled in with...

Gained weight on the transition, but eventually reta did its thing and was effective while still being able to enjoy food more than on other meds. I'm on tirz right now because i have to go off and on a bunch in coming months and i wouldn't want to do that with reta with its longer ramp-up time...

I am trying to give Reta some time. All that I have read says that it takes some time to move up and gain any kind of appetite suppression when you move from Tirz. I was at max dose Tirz, but recently a few months ago started TRT (I’m 48 and had really low test and bad symptoms, not doing cycles...

I'm back on my bs. Months of the tirz plateau so I decided to slowly transition to reta. Currently at tirz 10 and reta 5 but that's just not doing it for me on appetite. Got sick of latent hunger nagging all day so I mixed up a vial of cagri and got back on 0.5mg today. So far so good. Could...

As a precaution, I bought a KardiaMobile device which is an FDA-cleared personal EKG. I have bradycardia and occasional heart palpitations so I plan to use the device when/if I transition to reta. The app will provide an analysis of the EKG results.

I wouldn’t let this discourage you. I’m not maxed on Reta yet, just was curious preemptively. I don’t regret switching honestly

Oh man, this makes me not even want to try Reta. I’m n 18mg Tirz and have been stalled for months and it’s not as effective anymore, definitely don’t wanna go through another transition just to be maxed out again 🫤