2nd week, no effects

[CCamarillo87]

This has probably been talked about before but I'm just not finding anything. My research subject is on 2nd dose of 5mg tirz, last week was fabulous with appetite suppression and food noise. I started her at 5mg because she's been on compounded sema in 2023 and maxed out, and then started on 5mg compounded tirz last year with no effect at all. Frustrated and broke, I stopped researching. Recently got introduced to a vendor for research tirz but 2nd week and subject is seems so hungry.

Advice? 5mg was given evening on Wednesday so I've been thinking about giving another 1 or 2mg... but concerned "it needs to build up in the system" and that may be overkill?

 

[Iamnew2this]

I've noticed, some weeks are like that for me. I just let it go and let it take it's course. However, if I notice that I have a repeat week (I'm more hungry and not losing any weight), I most likely will take action and increase my dose or add a little something(usually by the 3rd week, but that's just me)Water and taking enough fiber(mostly supplements)is very important for me too. That can also help with hunger. In you case, you were on Ozempic. My advice to you would be, is to wait the week out and up your dosage next shot day and see how that dose works for you. I think it's better for your body to adjust to the tirz. That's just my opinion and advice. I really wish you luck!

 

[Calm Logic]

This would require zero thought for my simple male brain, haha. It would be 7.5 mg next time for me. But I would agree with waiting until the next scheduled weekly injection to keep things safe/simple.

 

[hexagonal]

This has probably been talked about before but I'm just not finding anything. My research subject is on 2nd dose of 5mg tirz, last week was fabulous with appetite suppression and food noise. I started her at 5mg because she's been on compounded sema in 2023 and maxed out, and then started on 5mg compounded tirz last year with no effect at all. Frustrated and broke, I stopped researching. Recently got introduced to a vendor for research tirz but 2nd week and subject is seems so hungry.

Advice? 5mg was given evening on Wednesday so I've been thinking about giving another 1 or 2mg... but concerned "it needs to build up in the system" and that may be overkill?

You don't have to do the research subject thing here. Everybody knows we're injecting this stuff ourselves.

7.5mg is considered the first therapeutic dose. Prescription dosing schedule is 2.5mg/w for 4 weeks, 5mg/w for 4 weeks, then 7.5mg

I personally would have followed the official schedule, but I was lucky in that I responded even to 2.5mg so I stayed on it for some time. Never made it past 5mg before I swapped to reta, where I largely followed the trial dosing schedule.

 

[CCamarillo87]

Thank you!

 

[nonyabizznez]

7.5mg is considered the first therapeutic dose. Prescription dosing schedule is 2.5mg/w for 4 weeks, 5mg/w for 4 weeks, then 7.5mg

With Mounjaro 5mg is considered a therapeutic dose.

The only reason I'm interjecting here is that many insurance companies cover only one month of step doses (2.5, 7.5,12.5mg). Some insurance companies are simply adhering to the dosing schedule submitted for FDA approval. If a patient is responding optimally at a step dose level it often requires physician overrides/prior authorizations. (continually, every refill). This is a path patients don't want to be on.

Side advice to those insecure with script coverage (basically for any drug)... Use Auto-fill whenever possible (particularly mail order) and opt for 90 day fills (with GLPs it's 84 but they time it properly). It's become so automated there's little room for human oversight. Much of the initial scrutiny of a script is being done (denied) by AI these days... Let the machines machine!

 

[hexagonal]

With Mounjaro 5mg is considered a therapeutic dose.

The only reason I'm interjecting here is that many insurance companies cover only one month of step doses (2.5, 7.5,12.5mg). Some insurance companies are simply adhering to the dosing schedule submitted for FDA approval. If a patient is responding optimally at a step dose level it often requires physician overrides/prior authorizations. (continually, every refill). This is a path patients don't want to be on.

Side advice to those insecure with script coverage (basically for any drug)... Use Auto-fill whenever possible (particularly mail order) and opt for 90 day fills (with GLPs it's 84 but they time it properly). It's become so automated there's little room for human oversight. Much of the initial scrutiny of a script is being done (denied) by AI these days... Let the machines machine!



View attachment 7048

I stand corrected!

 

[Calm Logic]

Not true but should be: The phrase "stand corrected" comes from the "sitting is the new smoking" school of therapeutikós.

 

[scarywood75]

If you started that expecting instant results, don't bother continuing

It's your second week, it's not even long enough to fully build up in your body.

You're gonna have ups and downs along the way and this isn't gonna be the last time

You need to put yourself into the proper mindset, you're gonna have to be at it for months, maybe years to reach your goal, 2 weeks is nothing.

Id say just follow the titration schedule, continue and don't bother if it doesn't do anything, be patient (you're gonna need a lot of it)

 

[Calm Logic]

If you have prediabetes, high cholesterol/triglycerides, wacky liver values, or your blood pressure is a little high, another option is to monitor your progress on those fronts and not just the scale. Or circle back with your primary care, tell them you are on compounded tirz and would like some baseline bloodwork.

 

[elenacooke10]

This has probably been talked about before but I'm just not finding anything. My research subject is on 2nd dose of 5mg tirz, last week was fabulous with appetite suppression and food noise. I started her at 5mg because she's been on compounded sema in 2023 and maxed out, and then started on 5mg compounded tirz last year with no effect at all. Frustrated and broke, I stopped researching. Recently got introduced to a vendor for research tirz but 2nd week and subject is seems so hungry.

Advice? 5mg was given evening on Wednesday so I've been thinking about giving another 1 or 2mg... but concerned "it needs to build up in the system" and that may be overkill?

Up the dose and frequency.