5’8” Dad Bod in a Battle with Autoimmune Shenanigans—Peptides to the Rescue?

[JuiceTico808]

Hello everyone!
I’m new to the world of peptides, and I’m here hoping to find something that can lend a hand (or, rather, a peptide chain!) in tackling the challenges of metabolic syndrome, dissecting folliculitis, and hidradenitis suppurativa. These autoimmune issues keep me on my toes, but I’m optimistic that with the insights and experiences shared here, I might find a few allies in the peptide family to help out.
A huge thank you to the forum’s creator and moderator—this community is a much-needed space to learn, discover, and grow within the peptide world. Looking forward to connecting with you all and diving into the journey ahead.

 

[Dee X]

Welcome!

What do you take for your other illnesses? Any biologics?

 

[cta7978]

Retatrutide and 5-amino-1MQ broke metabolic syndrome for me. Dropped 52 lbs since March from 242 to 190, doubled my free testosterone, that's with autoimmune thyroiditis to boot.

 

[cta7978]

For folliculitis, look into a NLRP3 inhibitor.. Maybe Luteolin?

 

[AndyPanda]

Hello everyone!
I’m new to the world of peptides, and I’m here hoping to find something that can lend a hand (or, rather, a peptide chain!) in tackling the challenges of metabolic syndrome, dissecting folliculitis, and hidradenitis suppurativa. These autoimmune issues keep me on my toes, but I’m optimistic that with the insights and experiences shared here, I might find a few allies in the peptide family to help out.
A huge thank you to the forum’s creator and moderator—this community is a much-needed space to learn, discover, and grow within the peptide world. Looking forward to connecting with you all and diving into the journey ahead.

Thymosin Alpha-1 https://www.peptides.org/thymosin-alpha-1/

 

[JuiceTico808]

Thank you so much for this reference! I will be sure to read up more on this peptide!
Much appreciated!

 

[JuiceTico808]

Welcome!

What do you take for your other illnesses? Any biologics?

Hello Dee X. Currently I am on Isotretinoin 40mg I have been taking it for 1.5 years started with 80mg for about 6 months then tapered down to 60mg for 4 months and then my current dose of 40mg. I have seen top dermatologists in my city and was recently referred to one of the top dermatologists and researchers in Hidradentitis Suppurativa who diagnosed me with HS. Another named disease in my list. He prescribed Clyndamicin and did suggest a biologic, Cosentyx. His office filled the prior auth paperwork to my insurance but at a cost of about 80k/year i dont know if they will approve. I Insurance did not want to approve Zepbound so I had to resort to compounding. Compounding started getting too expensive so I started finding different options and that is how ai wound up here.

 

[JuiceTico808]

For folliculitis, look into a NLRP3 inhibitor.. Maybe Luteolin?

Thank you cta7978! I will look into these. I appreciate your suggestions!

 

[JuiceTico808]

For folliculitis, look into a NLRP3 inhibitor.. Maybe Luteolin?

Thank you for the Luteolin suggestion. In reading more on it, it sounds promising. Do you have experience with this inhibitor? If so, do you suggest pills or is there an injectable form?
Any help/guidance is appreciated.

 

[cta7978]

Thank you for the Luteolin suggestion. In reading more on it, it sounds promising. Do you have experience with this inhibitor? If so, do you suggest pills or is there an injectable form?
Any help/guidance is appreciated.

I've been following the clinical development of NLRP3 inflammasome inhibitors Ventyx VTX3232 and VTX2735, as well as Nodthera's NT-0796. These drugs are currently in phase 2 clinical testing for both obesity and Parkinson's. Looks like NLRP3 inhibitors will be a game changer, potentially for many autoimmune conditions as well. Here is an article on NLRP3 inhibitors and HS.

Targeting the NLRP3 inflammasome reduces inflammation in hidradenitis suppurativa skin

Treatment for the debilitating disease hidradenitis suppurativa (HS) is inadequate in many patients, and a better understanding of its pathogenesis is requ

academic.oup.com

From my research, Luteolin is the best available natural NLRP3 inhibitor (until the pharma drugs are approved) I purchased a couple bottles of liposomal luteolin off Amazon, but waiting until my body stabilizes from my last experiment before adding to the mix. I have no idea what the appropriate dosage is.

I have autoimmune thyroiditis and research indicates that suppressing NLRP3 can inhibit the progression of AIT.

 

[DevynL90]

Hello Dee X. Currently I am on Isotretinoin 40mg I have been taking it for 1.5 years started with 80mg for about 6 months then tapered down to 60mg for 4 months and then my current dose of 40mg. I have seen top dermatologists in my city and was recently referred to one of the top dermatologists and researchers in Hidradentitis Suppurativa who diagnosed me with HS. Another named disease in my list. He prescribed Clyndamicin and did suggest a biologic, Cosentyx. His office filled the prior auth paperwork to my insurance but at a cost of about 80k/year i dont know if they will approve. I Insurance did not want to approve Zepbound so I had to resort to compounding. Compounding started getting too expensive so I started finding different options and that is how ai wound up here.

just an FYI, but getting coverage for an autoimmune disease is typically more standard than these new GLP1's. the PA requirements can be annoying but i'd be surprised if your insurance just didn't cover it at all.

additionally, novartis (drug creater) might have something like abbvie does w/ skyrizi where they'll pay the entire amount/portion of your medication while you navigate the insurance PA/appeals process.

definitely dig deep and work with your doctor and also give novartis a call as well while you're at it.

edit: check out here: https://www.novartis.com/us-en/pati...dicines should,them to afford their medicines.

 

[JuiceTico808]

I've been following the clinical development of NLRP3 inflammasome inhibitors Ventyx VTX3232 and VTX2735, as well as Nodthera's NT-0796. These drugs are currently in phase 2 clinical testing for both obesity and Parkinson's. Looks like NLRP3 inhibitors will be a game changer, potentially for many autoimmune conditions as well. Here is an article on NLRP3 inhibitors and HS.

Targeting the NLRP3 inflammasome reduces inflammation in hidradenitis suppurativa skin

Treatment for the debilitating disease hidradenitis suppurativa (HS) is inadequate in many patients, and a better understanding of its pathogenesis is requ

academic.oup.com

From my research, Luteolin is the best available natural NLRP3 inhibitor (until the pharma drugs are approved) I purchased a couple bottles of liposomal luteolin off Amazon, but waiting until my body stabilizes from my last experiment before adding to the mix. I have no idea what the appropriate dosage is.

I have autoimmune thyroiditis and research indicates that suppressing NLRP3 can inhibit the progression of AIT.
View attachment 3441

This is a wealth of information! Thank you very much!

 

[JuiceTico808]

just an FYI, but getting coverage for an autoimmune disease is typically more standard than these new GLP1's. the PA requirements can be annoying but i'd be surprised if your insurance just didn't cover it at all.

additionally, novartis (drug creater) might have something like abbvie does w/ skyrizi where they'll pay the entire amount/portion of your medication while you navigate the insurance PA/appeals process.

definitely dig deep and work with your doctor and also give novartis a call as well while you're at it.

edit: check out here: https://www.novartis.com/us-en/patients-and-caregivers/patient-assistance#:~:text=Novartis believes that medicines should,them to afford their medicines.

Well, I have great news, insurance approved Cosentyx! I hope the addition of this biologic will be a game changer to my treatment

 

[DevynL90]

i

Well, I have great news, insurance approved Cosentyx! I hope the addition of this biologic will be a game changer to my treatment

if it's not, don't lose hope. different biologics work for different people for literally the weirdest reasons and theyve all got tradeoffs and pros and cons. theres a lot of the market now and many more to come though. there's technically never been been a better time to have an autoimmune disease lol.