Wow. I am using the slowest titration up then. Started Tirz 35 weeks ago. Now at 10.4mg every 5 days. Started Cagri at 0.13mg/week, 11 weeks ago, increasing ~0.04mg each week, now at 0.5mg/6 days. Cagri is a nice booster but feel a bit nauseous too easily. Never on Tirz. Started Reta at 0.5mg/week 8 weeks ago, increasing about 0.16mg each week, and now at 1.5mg/week. Takes 3-4 weeks before you see full effect. Started low to reduce negative side effects. Loosing ~1.5 lbs a week. 0 exercise, sit at a desk all day. Down 55 lbs in 35 weeks. Past 4 weeks = 0 hunger. I actually don't like eating anymore. I don't want to titrate up to quickly in fear of loosing the magic too fast. Studies show most loose only half a pound a week after 36 weeks, and have to stay at max dosage for another 36 more weeks (on tirz). I have another 45 lbs to go, to hit BMI of 25. That's 30+ more weeks. Tirz half life is 5 days, 99% out your system by 30-32 days. End game plan: Tirz 5mg/week, no Cagri, 8mg/week on Reta. After reaching BMI goal: only Reta ~4mg/week for one more year, or will adjust maintenance based on more current data.