A lot to unpack here...but need advice

[black_tweets]

Hi all - appreciate you reading my novel. I had been doing a ton of research on Reta before I took my first dose on June 9th. I bought a 5mg bottle, reconstituted it with 2ml of BAC and started with a 0.25mg dose. Did that for 2 weeks, saw no change in appetite or weight loss, and then upped it to 0.50mg on June 23rd.

Issue #1: I had read about the vacuum in the bottles and to slowly add BAC to Reta...well it didn't work out that way and unfortunately it went in really fast. Could it have messed with the Reta and is that why I'm not seeing any results? I took my 2nd shot of 0.50mg Reta this Monday and haven't noticed any change in appetite.

Issue #2: Sunday June 22nd, I woke up with severe foot pain to the point that I was limping. It was all in my foot and felt like sharp nerve pain. Went to the doc on Monday and within 30 seconds he diagnosed me with plantar fasciitis...taped my foot and told me to come in a week later and I would be almost fully back to normal. Well I went back yesterday and told him that no, I'm still in pain; not limping because the taping and arch support sneakers help, but still in pain regardless. He seemed a little stumped. Prescribed an anti-inflammatory and I'm to go back in to see him in 2 weeks. I keep wondering if this is because of Reta? Looking back prior to Sunday, I was having a sight ache here and there in my left foot but I didn't think much of it (unfortunately, I can't recall when it started but pretty sure it was after starting my first dose of Reta). Saturday was a cardio day at my group fitness place and so we ran quite a bit so I can see how that aggravated my foot. My whole foot and ankle hurts...it also feels numb but when I touch it, it's fine, I feel the touch but there's this weird numbness I keep feeling. But could Reta be causing this?

Even though I haven't noticed any weight loss, I don't want to stop Reta. But I keep going around in circles: did I mess up when reconstituting the Reta and that's why it's ineffective and causing this foot pain? Would the foot pain still happen if I had done it right? Is this something that just happened and has nothing to do with Reta?

Would appreciate your thoughts on this....thank you!

 

[zpped]

#1 you definitely didn't hurt the reta. Nothing to worry about there.

#2 Never heard of anyone having this issue from reta or any side effects of that sort from the official study.

While I highly advocate going the low dose and slow titration route, 0.5mg of reta is a very small amount of reta.

 

[bbrewer]

Hi all - appreciate you reading my novel. I had been doing a ton of research on Reta before I took my first dose on June 9th. I bought a 5mg bottle, reconstituted it with 2ml of BAC and started with a 0.25mg dose. Did that for 2 weeks, saw no change in appetite or weight loss, and then upped it to 0.50mg on June 23rd.

Issue #1: I had read about the vacuum in the bottles and to slowly add BAC to Reta...well it didn't work out that way and unfortunately it went in really fast. Could it have messed with the Reta and is that why I'm not seeing any results? I took my 2nd shot of 0.50mg Reta this Monday and haven't noticed any change in appetite.

Issue #2: Sunday June 22nd, I woke up with severe foot pain to the point that I was limping. It was all in my foot and felt like sharp nerve pain. Went to the doc on Monday and within 30 seconds he diagnosed me with plantar fasciitis...taped my foot and told me to come in a week later and I would be almost fully back to normal. Well I went back yesterday and told him that no, I'm still in pain; not limping because the taping and arch support sneakers help, but still in pain regardless. He seemed a little stumped. Prescribed an anti-inflammatory and I'm to go back in to see him in 2 weeks. I keep wondering if this is because of Reta? Looking back prior to Sunday, I was having a sight ache here and there in my left foot but I didn't think much of it (unfortunately, I can't recall when it started but pretty sure it was after starting my first dose of Reta). Saturday was a cardio day at my group fitness place and so we ran quite a bit so I can see how that aggravated my foot. My whole foot and ankle hurts...it also feels numb but when I touch it, it's fine, I feel the touch but there's this weird numbness I keep feeling. But could Reta be causing this?

Even though I haven't noticed any weight loss, I don't want to stop Reta. But I keep going around in circles: did I mess up when reconstituting the Reta and that's why it's ineffective and causing this foot pain? Would the foot pain still happen if I had done it right? Is this something that just happened and has nothing to do with Reta?

Would appreciate your thoughts on this....thank you!

Probably unrelated to reta, I never heard of anything like that. That dose is so small I don't think you would see much suppression from it, based on my experience anyway.

 

[Calm Logic]

Never go barefoot again. That is a luxury for the young 🙁

There's also a foot surgeon who blogs that anyone with such issues should stretch their calves for 10 minutes a day, which is crazy to me.

 

[peptideusername]

Hi all - appreciate you reading my novel. I had been doing a ton of research on Reta before I took my first dose on June 9th. I bought a 5mg bottle, reconstituted it with 2ml of BAC and started with a 0.25mg dose. Did that for 2 weeks, saw no change in appetite or weight loss, and then upped it to 0.50mg on June 23rd.

Issue #1: I had read about the vacuum in the bottles and to slowly add BAC to Reta...well it didn't work out that way and unfortunately it went in really fast. Could it have messed with the Reta and is that why I'm not seeing any results? I took my 2nd shot of 0.50mg Reta this Monday and haven't noticed any change in appetite.

Issue #2: Sunday June 22nd, I woke up with severe foot pain to the point that I was limping. It was all in my foot and felt like sharp nerve pain. Went to the doc on Monday and within 30 seconds he diagnosed me with plantar fasciitis...taped my foot and told me to come in a week later and I would be almost fully back to normal. Well I went back yesterday and told him that no, I'm still in pain; not limping because the taping and arch support sneakers help, but still in pain regardless. He seemed a little stumped. Prescribed an anti-inflammatory and I'm to go back in to see him in 2 weeks. I keep wondering if this is because of Reta? Looking back prior to Sunday, I was having a sight ache here and there in my left foot but I didn't think much of it (unfortunately, I can't recall when it started but pretty sure it was after starting my first dose of Reta). Saturday was a cardio day at my group fitness place and so we ran quite a bit so I can see how that aggravated my foot. My whole foot and ankle hurts...it also feels numb but when I touch it, it's fine, I feel the touch but there's this weird numbness I keep feeling. But could Reta be causing this?

Even though I haven't noticed any weight loss, I don't want to stop Reta. But I keep going around in circles: did I mess up when reconstituting the Reta and that's why it's ineffective and causing this foot pain? Would the foot pain still happen if I had done it right? Is this something that just happened and has nothing to do with Reta?

Would appreciate your thoughts on this....thank you!

I'm not sure where so many people are getting this idea that a dose that's only 3.1% of the lowest clinically effective dose (8mg) will do anything for them?

I think a lot of people at that low of a dose are either stacking with other GLPs and/or have some placebo effect happening.

With that said, I had success at the lowest studied dose of tirz of 2.5mg (not .25mg!) and never had to titrate above 5 mg. So I know it's possible!
I just don't think the folks saying they have this huge appetite suppression from 250 or 500 mcg of Reta are truly responding solely to the drug.

Also, I agree with zpped - your Reta is fine and it didn't cause your foot injury. That would be an interesting data point for the studies!

 

[GLP1Pharmacist]

Does is so low, probably aren't going to see much, go low and slow, give if months.

 

[mlke6]

With all the research you did how did you come up with such a small dose to start?

 

[jemifus]

I’m not going to comment on the Reta though I think the others are right that it’s not related.

However my experience with plantar fasciitis is that it lasts much longer than a week. I actually ended up going to physical therapy for it, and the PT gave me an exercise that has cured it completely after struggling with it for years.

I call it a foot kegel because it feels so fricking weird, uses a muscle you aren’t used to using and you can do it whenever you want throughout the day.

Start by putting your bare foot on the ground while standing up. Then pull the ball of your foot towards your heel, but do not curl your toes. That’s it.

Takes a little bit to get the right muscle to contract, but once you get it you can contract that muscle with your shoes on, lying down whatever. After years of struggling with PF it went away completely with this exercise. I haven’t had PF symptoms in 6 years, but I still contract that muscle several times per day.

On top of that you can do the golf ball rollie thing, the calf stretches and whatever but it’s this weird little muscle contraction that really did the trick for me.

 

[rkl123]

I'm not sure where so many people are getting this idea that a dose that's only 3.1% of the lowest clinically effective dose (8mg) will do anything for them?

I think a lot of people at that low of a dose are either stacking with other GLPs and/or have some placebo effect happening.

With that said, I had success at the lowest studied dose of tirz of 2.5mg (not .25mg!) and never had to titrate above 5 mg. So I know it's possible!
I just don't think the folks saying they have this huge appetite suppression from 250 or 500 mcg of Reta are truly responding solely to the drug.

Also, I agree with zpped - your Reta is fine and it didn't cause your foot injury. That would be an interesting data point for the studies!

Agree. Dumbass youtubers started it. Now there's a whole cult dedicated to spinning your wheels.

 

[yobculture]

However my experience with plantar fasciitis is that it lasts much longer than a week.

That’s my experience, too. I’ve never heard of a doctor wrapping it up and saying it would be gone in a week. Plantar fasciitis is an ongoing thing that takes months of stretching and strength exercises to get relief. I’ve had it off and on for years, mainly because I walk so much. Some people get cortisone shots. I seriously doubt that Reta had anything to do with it. But I can’t really talk, because anything that changes in my body I immediately think, “OMG, is it the tirz?!?!”

 

[jemifus]

But I can’t really talk, because anything that changes in my body I immediately think, “OMG, is it the tirz?!?!”

I had some weird knee pain in my first week of Tirz and thought the same thing.

 

[FlowerFairy]

Hi all - appreciate you reading my novel. I had been doing a ton of research on Reta before I took my first dose on June 9th. I bought a 5mg bottle, reconstituted it with 2ml of BAC and started with a 0.25mg dose. Did that for 2 weeks, saw no change in appetite or weight loss, and then upped it to 0.50mg on June 23rd.

Issue #1: I had read about the vacuum in the bottles and to slowly add BAC to Reta...well it didn't work out that way and unfortunately it went in really fast. Could it have messed with the Reta and is that why I'm not seeing any results? I took my 2nd shot of 0.50mg Reta this Monday and haven't noticed any change in appetite.

Issue #2: Sunday June 22nd, I woke up with severe foot pain to the point that I was limping. It was all in my foot and felt like sharp nerve pain. Went to the doc on Monday and within 30 seconds he diagnosed me with plantar fasciitis...taped my foot and told me to come in a week later and I would be almost fully back to normal. Well I went back yesterday and told him that no, I'm still in pain; not limping because the taping and arch support sneakers help, but still in pain regardless. He seemed a little stumped. Prescribed an anti-inflammatory and I'm to go back in to see him in 2 weeks. I keep wondering if this is because of Reta? Looking back prior to Sunday, I was having a sight ache here and there in my left foot but I didn't think much of it (unfortunately, I can't recall when it started but pretty sure it was after starting my first dose of Reta). Saturday was a cardio day at my group fitness place and so we ran quite a bit so I can see how that aggravated my foot. My whole foot and ankle hurts...it also feels numb but when I touch it, it's fine, I feel the touch but there's this weird numbness I keep feeling. But could Reta be causing this?

Even though I haven't noticed any weight loss, I don't want to stop Reta. But I keep going around in circles: did I mess up when reconstituting the Reta and that's why it's ineffective and causing this foot pain? Would the foot pain still happen if I had done it right? Is this something that just happened and has nothing to do with Reta?

Would appreciate your thoughts on this....thank you!

Your Reta survived the recon. Peptides are not as fragile as we have been told- Janoshik (sp?) posted a video of him shaking a vial vigorously, plus the test after. No appreciable effect.

Are you GLP naive? I can’t otherwise think of a reason to start so low. One thing to remember though- it takes 4 weeks for Reta to reach full efficacy, so I’d wait 4 weeks between increases, except that you started so very low- I’d bump it to 2 mg at least.

I got plantar fasciitis years ago. My doctor gave me some stretches and told me I’d probably have to live with flares for the rest of my life. What has worked best for me essentially “curing” it (no flares for 20+ years) is a combination of the surgeon mentioned by calm logic and the stretch mentioned by the other poster. I started about 2 feet out from the wall, put my hands palms flat and lean forward, keeping my feet as flat as possible and slowly increase the distance from the wall. I ended up about 4 feet out from the wall- it stretched my calves, the tendons on the backs of my ankles, and as I leaned forward, eventually the tendons in my feet. Mine was bad first thing in the morning, both feet. I don’t remember how long it took to work the pain out, but it worked fairly quickly. I used to do those stretches a few times a week, then a month, now only if I have a flare. And no, never heard of it being caused by Reta. I tend to wear plastic sandals made by a company named DAWGS that claim their footbeds help ease plantar fasciitis. Not sure if that’s true, but they are comfortable so I wear them most days.

Good luck on your journey, and welcome!

 

[Sun_Seeker]

Your Reta survived the recon. Peptides are not as fragile as we have been told- Janoshik (sp?) posted a video of him shaking a vial vigorously, plus the test after. No appreciable effect.

Are you GLP naive? I can’t otherwise think of a reason to start so low. One thing to remember though- it takes 4 weeks for Reta to reach full efficacy, so I’d wait 4 weeks between increases, except that you started so very low- I’d bump it to 2 mg at least.

I got plantar fasciitis years ago. My doctor gave me some stretches and told me I’d probably have to live with flares for the rest of my life. What has worked best for me essentially “curing” it (no flares for 20+ years) is a combination of the surgeon mentioned by calm logic and the stretch mentioned by the other poster. I started about 2 feet out from the wall, put my hands palms flat and lean forward, keeping my feet as flat as possible and slowly increase the distance from the wall. I ended up about 4 feet out from the wall- it stretched my calves, the tendons on the backs of my ankles, and as I leaned forward, eventually the tendons in my feet. Mine was bad first thing in the morning, both feet. I don’t remember how long it took to work the pain out, but it worked fairly quickly. I used to do those stretches a few times a week, then a month, now only if I have a flare. And no, never heard of it being caused by Reta. I tend to wear plastic sandals made by a company named DAWGS that claim their footbeds help ease plantar fasciitis. Not sure if that’s true, but they are comfortable so I wear them most days.

Good luck on your journey, and welcome!

YES! YES! YES! I came here to add this exact stretch. Cured me. And I haven't had any flareups since then (knock wood).

Black_Tweets, I've gotta wonder, did the reta cause you to shed some water weight which was masking some of the pain from the planter fascitis? All my old, creaky joints tend to squeal when the water weight is flushing.

 

[black_tweets]

With all the research you did how did you come up with such a small dose to start?

I'm looking to loose around 30lbs. I'm in my 40s, diabetic, weight doesn't budge even though I workout 6 days a week. I could be eating better but alas, life. I was terrified of starting at a higher does because 1) I can't stand being nauseous and 2) I didn't want to go any higher than 5mg ever while taking this. This is also the first peptide I've tried. Everywhere I read, people said to start low and go slow so that's why I started with 0.25mg. Plan is next Monday to move up to 1mg.

 

[black_tweets]

I’m not going to comment on the Reta though I think the others are right that it’s not related.

However my experience with plantar fasciitis is that it lasts much longer than a week. I actually ended up going to physical therapy for it, and the PT gave me an exercise that has cured it completely after struggling with it for years.

I call it a foot kegel because it feels so fricking weird, uses a muscle you aren’t used to using and you can do it whenever you want throughout the day.

Start by putting your bare foot on the ground while standing up. Then pull the ball of your foot towards your heel, but do not curl your toes. That’s it.

Takes a little bit to get the right muscle to contract, but once you get it you can contract that muscle with your shoes on, lying down whatever. After years of struggling with PF it went away completely with this exercise. I haven’t had PF symptoms in 6 years, but I still contract that muscle several times per day.

On top of that you can do the golf ball rollie thing, the calf stretches and whatever but it’s this weird little muscle contraction that really did the trick for me.

wow - thank you so much!! I'll give this a shot!

 

[black_tweets]

Black_Tweets, I've gotta wonder, did the reta cause you to shed some water weight which was masking some of the pain from the planter fascitis? All my old, creaky joints tend to squeal when the water weight is flushing.

Haven't lost any weight yet so can't be that I guess.

 

[ocuzuc]

Hi all - appreciate you reading my novel. I had been doing a ton of research on Reta before I took my first dose on June 9th. I bought a 5mg bottle, reconstituted it with 2ml of BAC and started with a 0.25mg dose. Did that for 2 weeks, saw no change in appetite or weight loss, and then upped it to 0.50mg on June 23rd.

Issue #1: I had read about the vacuum in the bottles and to slowly add BAC to Reta...well it didn't work out that way and unfortunately it went in really fast. Could it have messed with the Reta and is that why I'm not seeing any results? I took my 2nd shot of 0.50mg Reta this Monday and haven't noticed any change in appetite.

Issue #2: Sunday June 22nd, I woke up with severe foot pain to the point that I was limping. It was all in my foot and felt like sharp nerve pain. Went to the doc on Monday and within 30 seconds he diagnosed me with plantar fasciitis...taped my foot and told me to come in a week later and I would be almost fully back to normal. Well I went back yesterday and told him that no, I'm still in pain; not limping because the taping and arch support sneakers help, but still in pain regardless. He seemed a little stumped. Prescribed an anti-inflammatory and I'm to go back in to see him in 2 weeks. I keep wondering if this is because of Reta? Looking back prior to Sunday, I was having a sight ache here and there in my left foot but I didn't think much of it (unfortunately, I can't recall when it started but pretty sure it was after starting my first dose of Reta). Saturday was a cardio day at my group fitness place and so we ran quite a bit so I can see how that aggravated my foot. My whole foot and ankle hurts...it also feels numb but when I touch it, it's fine, I feel the touch but there's this weird numbness I keep feeling. But could Reta be causing this?

Even though I haven't noticed any weight loss, I don't want to stop Reta. But I keep going around in circles: did I mess up when reconstituting the Reta and that's why it's ineffective and causing this foot pain? Would the foot pain still happen if I had done it right? Is this something that just happened and has nothing to do with Reta?

Would appreciate your thoughts on this....thank you!

It seems unlikely that reta would cause plantar fasciitis. I had it 20 years ago, it took about a year to get corrected. Basketball players get it a lot, when they do, they are done for the season. I couldn’t walk at all some days it was that bad. I had to have cortisone shots, which worked wonders, but my podiatrist used them sparingly as long term effects are bad. I did the stretches but eventually had to get an Rx night splint. Talk to your doctor about that, but you can probably buy them direct for cheaper than your Rx copay — https://www.braceability.com/products/plantar-fasciitis-stretching-night-splint
And also losing weight helped too. Good luck, I know your pain. If your doctor isn’t a podiatrist, you may want to seek a specialist.

 

[Morbius]

You may find that you will be unable to meet your goals with a maximum allowable dose of 5 mg. These are the average percent losses by dose from the phase 2 trials.

• 1 mg: -8.7%
• 4 mg: -17.1%
• 8 mg: -22.8%
• 12 mg: -24.2%

If you have found some research that doses above 5 mg are not advised, I think that would be new information to most of us.

 

[dogmom]

I would just take 2mg for the next dose and stay on that once a week for 3 to 4 weeks.

 

[toologic]

Not sure about going barefoot but I can attest that many issues with feet (like plantar fasciitis, achilles tendonitis) can be alleviated with proper stretching of the calf. I have a foam incline board in front of the vanity that I stand on every morning and evening while getting ready. I haven't had a problem in 6 years since doing this and I had chronic issues. I also swear by the cloud massager.

 

[Calm Logic]

I forget some people have carpeting. I only have hard floors:

Plantar fasciitis

Find out about plantar fasciitis, including the causes, the symptoms and how to ease them, when to get medical help and treatments from a specialist.

www.nhs.uk

 

[zpped]

You may find that you will be unable to meet your goals with a maximum allowable dose of 5 mg. These are the average percent losses by dose from the phase 2 trials.

• 1 mg: -8.7%
• 4 mg: -17.1%
• 8 mg: -22.8%
• 12 mg: -24.2%

If you have found some research that doses above 5 mg are not advised, I think that would be new information to most of us.

Those are also time constrained values. So they are definitely not maximums. ( I lost 40% staying under 8mg)

 

[zpped]

I'm looking to loose around 30lbs. I'm in my 40s, diabetic, weight doesn't budge even though I workout 6 days a week. I could be eating better but alas, life. I was terrified of starting at a higher does because 1) I can't stand being nauseous and 2) I didn't want to go any higher than 5mg ever while taking this. This is also the first peptide I've tried. Everywhere I read, people said to start low and go slow so that's why I started with 0.25mg. Plan is next Monday to move up to 1mg.

1 mg is enough for most people to start seeing an effect.

 

[pavlovs]

One of the better "did my glp1 cause..." posts was made by someone who had taken their first dose the day before their 29 year old dog died in his sleep. I don't know if anyone was able to convince the gal that the dog didn't somehow overdose from tirz seeping through her pores.

If you are a gal, stop wearing high heels and wear slippers around the house with support. I got PF by running without shoes, like Zola Budd. Was fine when I was a kid, but now the old dogs need support 🙂 Good luck with the reta!

 

[IrishLeoMurphy]

I had severe PF a few years ago after suddenly running after my dog (I was also overweight, of course). It was horribly painful.

I did three things to help get rid of it. I used a night splint that I ordered off of Amazon. It used velcro straps to pull my toes slightly toward my shin during the night. I also used rubber inserts (Heel Seats) in my shoes (also Amazon) from Heal That Pain. The third thing was a cortisone shot in my foot. Thank God I only had to get one and with everything else, my PF finally went away.

 

[Calm Logic]

My favorite shoes are the rocker-bottom sneakers, like by Skechers and originally designed (?) by HOKA. That helps the most with my Achilles tendonitis, even more than heel inserts.

I can't stand the night splints. But I know stretching is important, and you can't stretch too much, at least for those parts of the body.

 

[Bflo_Bflo_Bflo_Bfl]

I had PF for years. Thing that finally got rid of it was to wear the horrible uncomfortable orthotics until the most recent flare up was gone, and then ease my way into 0 drop wide toebox shoes. I started with Hokas with a wide size and a 5mm drop, then got some Altras I cycled into my daily shoe rotation one day a week, then two, etc. until I was wearing them full time.

 

[YoYoFat]

Agree with everyone else. Reta dose is too low to experience any real benefits, and almost certainly didn’t cause your PF that is incredibly common among overweight people and can take a very long time to heal.

I know it’s scary to try something new then experience something odd and how easy it is to link the two. But they’re not related.

 

[toologic]

Another tidbit to add--you can't go wrong by going to a really good shoe store that has the expertise to watch how you walk/run and determining if you need a neutral/overpronation/heel striker, mid sole striker etc to get the right shoe. Even if the shoe feels good , it may not be the right shoe. I was wearing zero drop Newtons for several years until I developed achilles problems. I didn't want to believe it but switched to Brooks Ghost. After a year of wearing the Brooks, I tried to go back to Newton and within a couple of weeks my achilles started flaring. They were donated.