Abnormal Lab Results in Phase 3 Participant

[fatbegone]

This guy is in one of the phase 3 retatrutide trials. He recently had abnormal lab results. I think he said previously he's on the 12mg dose. He's hoping (as are we who are on reta) that it's not due to reta.

Thread by @eecklund on Thread Reader App

@eecklund: Clinical trial update. As of today, it's been 28 days since I last took Retatrutide. I was asked to suspend the last three doses due to abnormal hepatic function labs, indicating liver damage, and CBC lab...…

threadreaderapp.com

 

[indolent]

I wonder if this sort of exception is why (see other recent thread) EL isn't playing up Reta in their corporate/investor communications.

 

[fatbegone]

I wonder if this sort of exception is why (see other recent thread) EL isn't playing up Reta in their corporate/investor communications.

My gut feeling is it's not due to reta. I feel like it would have manifested in the phase 2 trials if it were due to reta. But maybe that's just me really not wanting it to be the reta.

 

[keangkong]

Ouch. I’m at the liver doctor’s office due to greatly elevated liver enzymes that were higher than when I started and which are not caused by fatty liver, a disorder that I do not have.

 

[dogmom]

I've been on reta for over a year. I have to get labs every 3 months because I've an autoimmune disorder and I'm on an immuno suppressant than can cause liver issues. I haven't had any changes since starting reta. Just my personal anecdote.

 

[MsGizmo]

Rapid or extreme weight loss can cause abnormal hepatic function by triggering a massive mobilization of fats from adipose tissue to the liver, which can lead to non-alcoholic steatohepatitis (NASH) and even liver failure in some cases. However, a controlled and gradual weight loss, especially for obese individuals with fatty liver disease, often improves liver enzymes and reduces liver fat. The key is to avoid rapid weight loss, with a recommended rate of no more than 1.6 kg (3.5 lbs) per week.

Aggressive non-alcoholic steatohepatitis following rapid weight loss and/or malnutrition - PMC

While non-alcoholic steatohepatitis is a slowly progressive disease, patients may rarely present in acute liver failure. We describe six patients who developed severe hepatic dysfunction following rapid weight loss or malnutrition. Rapid weight loss ...

pmc.ncbi.nlm.nih.gov

We must always remember that being obese is a health risk and losing weight too fast is a health risk. I don't know how long this person was on reta or how much weight he lost. Rushing to blame the drug itself is a bit premature.

 

[fatbegone]

Rapid or extreme weight loss can cause abnormal hepatic function by triggering a massive mobilization of fats from adipose tissue to the liver, which can lead to non-alcoholic steatohepatitis (NASH) and even liver failure in some cases. However, a controlled and gradual weight loss, especially for obese individuals with fatty liver disease, often improves liver enzymes and reduces liver fat. The key is to avoid rapid weight loss, with a recommended rate of no more than 1.6 kg (3.5 lbs) per week.

Aggressive non-alcoholic steatohepatitis following rapid weight loss and/or malnutrition - PMC

While non-alcoholic steatohepatitis is a slowly progressive disease, patients may rarely present in acute liver failure. We describe six patients who developed severe hepatic dysfunction following rapid weight loss or malnutrition. Rapid weight loss ...

pmc.ncbi.nlm.nih.gov

We must always remember that being obese is a health risk and losing weight too fast is a health risk. I don't know how long this person was on reta or how much weight he lost. Rushing to blame the drug itself is a bit premature.

This might be the cause. This person started the reta trial in early May of 2024 at a weight of 355lbs. In March of 2025 his weight was 176lbs, a total weight loss of 179lbs in 10 months. That's an average weight loss of 17.9lbs per month, or about 4.5lbs per week. That's insanely fast and way more than the 3.5lbs you mentioned.

 

[IshimaruKenta]

Let me ask this stupid question. Do the scientists who create these drugs ever make changes due to the trial outcomes? Or does the formula stay the same the entire time?

 

[Airborne Daddy]

Ouch. I’m at the liver doctor’s office due to greatly elevated liver enzymes that were higher than when I started and which are not caused by fatty liver, a disorder that I do not have.

What's greatly buddy? More than double?

 

[Airborne Daddy]

This might be the cause. This person started the reta trial in early May of 2024 at a weight of 355lbs. In March of 2025 his weight was 176lbs, a total weight loss of 179lbs in 10 months. That's an average weight loss of 17.9lbs per month, or about 4.5lbs per week. That's insanely fast and way more than the 3.5lbs you mentioned.

Or maybe an above average drinker. Weird my old knees be killing me 2 days after last pin.

 

[indolent]

Let me ask this stupid question. Do the scientists who create these drugs ever make changes due to the trial outcomes? Or does the formula stay the same the entire time?

I think the drug is one molecule. So I don't think they can make changes, as such. Maybe to the dosage/administration protocol. But perhaps I'm wrong.