About to start Sermorelin, what to expect?

[PablinhoDoFavela]

expecting muscle gain, fat loss

Mainly scared of the cell growth thing and cancer. Would like to know I’m really in a risk. Are results any good with this peptide? Heard Tesa Is stronger but riskier

I work out regularly as well.

 

[clevesand]

Following. This has been on my radar as well. I even searched for it recently with my regular US warehouse vendors (that are still around) G and BFF and it didn't look like the carried it

 

[Dblue511]

I started it a week ago. Many people say there is water retention for the first couple of weeks but I haven’t experienced it yet. I did start with a very low dose to check reaction. I do 150mcg Sun-Thur, 30min before bed. On those days I sleep like a rock!

 

[AndyPanda]

expecting muscle gain, fat loss

Mainly scared of the cell growth thing and cancer. Would like to know I’m really in a risk. Are results any good with this peptide? Heard Tesa Is stronger but riskier

I work out regularly as well.

How old are you? Theoretically, Sermorelin MAY increase IGF-1 by UP TO 30% in men and 23% in women. You would not definitively know your levels without a blood test for those specific markers, but we can make assumptions.

Up into your 20s, you produce high numbers because it’s there to help you grow, so lets estimate 700 ng/mL just for reference. After age 40 it drops significantly! We will estimate
90 ng/mL or lower. 30% of 90 isn’t enough to see any changes over something like a 16 week cycle.

Unless you are relatively young, I just try to encourage people to look into HGH. Its benefits for anti-aging, skin, muscle mass, bone strength, etc. are phenomenal. Additionally, as a general rule, any supplements, peptides or hormones that help build muscle can accelerate cancer and/or tumor growth.

There is a lot of demonizing of HGH because people abuse it, and the people who generally abuse it are young and don’t need it, so their organs grow and screw everything up. Especially their hearts.

As much as I believe that moderation is for cowards, you should definitely play it safe with Growth Hormone, but it’s an amazing tool. 1-2iu daily on an empty stomach about an hour before bed to start. 3-4iu to really build muscle. A lot of bodybuilders go above those numbers, but they have the life expectancy of a Great Dane.

 

[rpm2026]

Expect flatuence and better sleep

 

[digeraro]

I don't think there is much research data regarding the health risks. Best thing is get a full blood work up done including PSA and IGF-1. It will give you a baseline. If everything is good it may make you feel better. Take note of your IGF-1 number before you start then when you finish your cycle. Your IGF-1 levels can indicate the effects the growth secretagogues are having on your body.

Again your age is a big factor.

I'm over 60+ tried all of the popular secretagogues. None had a noticeable effect. Most made my sleep worse. Ipamorelin though will stimulate your appetite for sure. I was told by a health coach at my age the only few things that I could expect results were HGH and or test. Im not ready for either but on the fence with HGH.

 

[cygnus]

Sermorelin and tesamorelin both made it through FDA approval; the risks are known and found to be well tolerated. Personally, I think tesamorelin is great and pairs extremely well with ipamorelin.

Starting low and going slow on serm is a smart move for your risk assessment. See how you like it; some people I know just feel hungry on it, some sleep better, some felt nothing. Mileage varies, just like any drug. Let us know how it goes.

 

[HZM808]

As a menopausal woman, quality sleep was the greatest gift from sermorelin and now ipamorelin.

 

[PablinhoDoFavela]

How old are you? Theoretically, Sermorelin MAY increase IGF-1 by UP TO 30% in men and 23% in women. You would not definitively know your levels without a blood test for those specific markers, but we can make assumptions.

Up into your 20s, you produce high numbers because it’s there to help you grow, so lets estimate 700 ng/mL just for reference. After age 40 it drops significantly! We will estimate
90 ng/mL or lower. 30% of 90 isn’t enough to see any changes over something like a 16 week cycle.

Unless you are relatively young, I just try to encourage people to look into HGH. Its benefits for anti-aging, skin, muscle mass, bone strength, etc. are phenomenal. Additionally, as a general rule, any supplements, peptides or hormones that help build muscle can accelerate cancer and/or tumor growth.

There is a lot of demonizing of HGH because people abuse it, and the people who generally abuse it are young and don’t need it, so their organs grow and screw everything up. Especially their hearts.

As much as I believe that moderation is for cowards, you should definitely play it safe with Growth Hormone, but it’s an amazing tool. 1-2iu daily on an empty stomach about an hour before bed to start. 3-4iu to really build muscle. A lot of bodybuilders go above those numbers, but they have the life expectancy of a Great Dane.

Im 25 lol

 

[Super Trips]

I would run Tesa first it’s lighter duty than serm. And has less effects to start

 

[AndyPanda]

Im 25 lol

It would probably help then. I would take Ipamorelin and Sermorelin though. Ipamorelin triggers and Sermorelin releases. Take 300-500mcg fasted. You probably don’t need GH.

 

[Calm Logic]

You probably don’t need GH.

Bingo. "You can never get enough of what you don't need."

I would run Tesa first it’s lighter duty than serm. And has less effects to start

More like the other way around.

 

[hexagonal]

expecting muscle gain, fat loss

Expect minimal results, particularly for muscle gain. Even HGH by itself in the absence of steroids is a pretty minimal effects. It's not nothing, but it's not going to be nearly as transformative as the GLP-1s are for weight or going on TRT after being hypogonadal.

IGF-1 is a hot topic in research right now because there's a craze for just upping the number of receptors these drugs hit and it's well popularized that muscle loss is a risk when on them, so throwing in some mitigating factors there helps sell the drug.

Mainly scared of the cell growth thing and cancer. Would like to know I’m really in a risk. Are results any good with this peptide? Heard Tesa Is stronger but riskier

I work out regularly as well.

The downstream increase to IGF-1 is, from current understanding, the single biggest factor in the muscle growth/tissue repair/etc. benefits of HGH and the peptides that increase endogenous production. It's also the single biggest factor in risk of increasing cancer growth rates. You can't currently disentangle them.

I no longer bother with the -morelins and similar and just go straight to HGH since my understanding is that the rsk is largely dependent on the IGF-1 level, so when level matched, no real difference in safety profile between them in that regard, and HGH is actually kinder to my insulin sensitivity than the -morelin stack was.

 

[Calm Logic]

Expect minimal results, particularly for muscle gain. Even HGH by itself in the absence of steroids is a pretty minimal effects. It's not nothing, but it's not going to be nearly as transformative as the GLP-1s are for weight or going on TRT after being hypogonadal.

Yeah, I see GH peptides as being surpassed by TRT and GLPs except for some things like tendon collagen synthesis:

https://www.researchgate.net/publication/40027103_Growth_hormone_stimulates_the_collagen_synthesis_in_human_tendon_and_skeletal_muscle_without_affecting_myofibrillar_protein_synthesis

For tendonitis, it seems BPC and TB would be more effective than HGH, on paper, due to angiogenesis in particular from BPC and cell migration in particular from TB:

Feature	BPC-157	TB-500	HGH	GHK-Cu	KPV
Primary Role	Structural Repair	Cell Migration	Raw Volume	Remodeling	Anti-Inflammatory
Collagen Impact	Increases Type I (Tendon strength)	Supports flexible tissue	Massive Type I synthesis	Type I & III (Skin/Elasticity)	Neutral (Indirectly protective)
Mechanism	Upregulates GH receptors; Angiogenesis.	Actin-binding; moves cells to injury.	Direct mRNA signaling; IGF-1.	Epigenetic: Resets genes to youthful state.	Cytokine Control: Blocks NF-kB path.
The "Vibe"	"Glue it back together."	"Clear the path and move."	"Make everything bigger."	"Make it look/feel young."	"Kill the fire (inflammation)."
Tendonitis Utility	High: Fixes micro-tears.	High: Improves mobility/scarring.	Moderate: Thickens the tissue.	Moderate: Refines tissue quality.	High: Rapidly kills the "ache."

BPC/TB is a "Surgical" repair; HGH is a "Broad-spectrum" repair.

• HGH: Increases the pool of available collagen, but doesn't "know" where to put it.
• BPC-157: Creates the blood supply (angiogenesis) to the specific injury site.
• TB-500: Ensures the new tissue is flexible by migrating cells and preventing adhesions.

Verdict: For acute tendonitis, the BPC/TB combo addresses the root cause (lack of blood/migration) whereas HGH just increases the raw volume of structural protein.

 

[Windingroads06]

As a menopausal woman, quality sleep was the greatest gift from sermorelin and now ipamorelin.

This! Love the sleep!

 

[PablinhoDoFavela]

So I could lose muscle while I run sermo 😭?

IGF-1 is a hot topic in research right now because there's a craze for just upping the number of receptors these drugs hit and it's well popularized that muscle loss is a risk when on them, so throwing in some mitigating factors there helps sell the drug.

 

[Sparky757]

So I could lose muscle while I run sermo 😭?

No, hexagonal is referring to how people who use the current weight loss drugs like semaglutide and tirzepatide also lose muscle. There is a lot of research by big pharma to see how to mitigate muscle loss in newer versions of weight loss drugs like these.

For you, at 25 years old, the -morelin drugs may not have so much of an effect besides good sleep (if anything) because your growth hormone production is still quite high at your age (you can get blood tests to confirm this). The oldies like me who research the -morelins are honestly trying to recapture your growth hormone levels.

 

[AndyPanda]

No, hexagonal is referring to how people who use the current weight loss drugs like semaglutide and tirzepatide also lose muscle. There is a lot of research by big pharma to see how to mitigate muscle loss in newer versions of weight loss drugs like these.

For you, at 25 years old, the -morelin drugs may not have so much of an effect besides good sleep (if anything) because your growth hormone production is still quite high at your age (you can get blood tests to confirm this). The oldies like me who research the -morelins are honestly trying to recapture your growth hormone levels.

It works better for younger people. If it increases 30% of nothing, the results are nothing. That’s why GH is better for us old heads, and the secretagogues are more effective for the younger crown.

 

[Sparky757]

Hmmm. You could be right, Panda. I was under the impression that the -morelins were all limited to the body's natural limit of GH production and secretion. That it had a ceiling at maybe the limit of the research subject's own max GH levels around their earlier peaks in youth. That's why it had a more pronounced effect on those with growth hormone disorders (like those for which sermorelin was originally created) and people who are older whose GH production had naturally waned with age. Because youngsters' endocrine systems are already squirting out at max levels, it was going to be less effective for them than in those with decreased GH from disease or aging. I had kind of assumed peptides were an old man's game so to speak because of this.

 

[hexagonal]

So I could lose muscle while I run sermo 😭?

Whether or not you lose muscle depends on your diet and training more than anything when it comes to losing weight while on GLP-1s. Things like TRT (or TRT+) and GH secretagogues (or HGH) will slow down muscle loss if you don't hit your macros and don't do resistance training, but they won't stop it. If you do have your diet and training dialed in you will maybe see slightly more muscle gain than if you weren't taking sermorelin, but by itself it won't do much.

If your goal in taking anything GH related is gaining muscle, you're not going to get particularly amazing results if the GH stuff is the only stuff in your stack. It's more of small multiplier when it comes to muscle gain - otherwise natural muscle gain is pretty slow, so the multiplier doesn't do a whole lot in absolute terms. When you have increased the baseline by quite a bit with AAS, though, that small multiplier can mean multiple more lb of muscle every year.