SURPASS-2 study showed: "increases in total adiponectin (16-23% vs -.2%) with tirzepatide vs placebo"
Would you like to know more about adiponectin? I sure did. Especially with all the comments like "of course you loose weight if you eat less calories!" and "it just makes you eat less". I could tell from my own journey that WAY more than CICO (calories in, calories out) was occurring, kcal could NOT account for the speed of the weight loss! So here are the notes I took on my deep dive, they might bemmseen haphazard, but hopefully you can glean something useful. (I am not medical professional, and might be interpreting things incorrectly).
In short, adiponectin allows cells to burn fat for fuel more easily (lipolysis). And there is so much more! Read on.
○
○ Tirzepatide has been reported to increase levels of adiponectin, an adipokine involved in the regulation of both glucose and lipid metabolism, with a maximum increase of 26% from baseline after 26 weeks, at the 10 mg dosage. STUDY LINK: https://academic.oup.com/jcem/article/106/2/388/6000489?login=false)
○ metabolic syndrome often leads to left ventricular hypertrophy. low adiponectin is best predictor of LVH!
○ mice with increased adiponectin show reduced adipocyte differentiation (creation into fat cells... I think! need to dig deeper on this)
○ mice with increased adiponectin show increased energy expenditure associated with mitochondrial uncoupling. (I am *very* interested in the mitochondrial uncoupling! this is like burning "free" kcal, roughly). STUDY LINK: https://academic.oup.com/endo/article/148/4/1539/2501482?login=false
○ adiponectin suppresses the metabolic derangements that may result in:
*type 2 diabetes [pubmed.ncbi.nlm.nih.gov/12436346/]
*obesity
*atherosclerosis [pubmed.ncbi.nlm.nih.gov/12611609]
*non-alcoholic fatty liver disease (NAFLD)
*risk factor for metabolic syndrome
[https://pubmed.ncbi.nlm.nih.gov/19258676]
○ Adiponectin in combination with leptin has been shown to completely reverse insulin resistance in mice.[https://pubmed.ncbi.nlm.nih.gov/11479627]
○ coronary artery disease has been found to be positively associated with high molecular weight adiponectin, but not with low molecular weight adiponectin.[https://pubmed.ncbi.nlm.nih.gov/20398150]
○ Adiponectin exerts some of its weight reduction effects via the brain. This is similar to the action of leptin (in factb adiponectin and leptin can act synergistically) [https://pubmed.ncbi.nlm.nih.gov/11479627]
○ Adiponectin promoted synaptic and memory function in the brain. Humans with lower levels of adiponectin have reduced cognitive function.[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340072]
○ Contrary to expectations, despite being produced in adipose (fat) tissue, adiponectin was found to be decreased in obesity (too many studies to list here). This downregulation has not been fully explained
○ Berberine, an isoquinoline alkaloid, has been shown to increase adiponectin expression, which partly explains its beneficial effects on metabolic disturbances. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788178]
○ Mice fed the omega-3 fatty acids (EPA and DHA) have shown increased plasma adiponectin. Curcumin, capsaicin, gingerol, and catechins also increase adiponectin expression.
○ adiponectin is low in Alzheimer’s [https://www.eurekalert.org/news-releases/538252]
○ Adiponectin reduces mitochondrial dysfunction (and reduces endothelial activation and pulmonary vascular injury) [https://faseb.onlinelibrary.wiley.com/doi/ftr/10.1096/fj.201901123R]
Would you like to know more about adiponectin? I sure did. Especially with all the comments like "of course you loose weight if you eat less calories!" and "it just makes you eat less". I could tell from my own journey that WAY more than CICO (calories in, calories out) was occurring, kcal could NOT account for the speed of the weight loss! So here are the notes I took on my deep dive, they might bemmseen haphazard, but hopefully you can glean something useful. (I am not medical professional, and might be interpreting things incorrectly).
In short, adiponectin allows cells to burn fat for fuel more easily (lipolysis). And there is so much more! Read on.
○
○ Tirzepatide has been reported to increase levels of adiponectin, an adipokine involved in the regulation of both glucose and lipid metabolism, with a maximum increase of 26% from baseline after 26 weeks, at the 10 mg dosage. STUDY LINK: https://academic.oup.com/jcem/article/106/2/388/6000489?login=false)
○ metabolic syndrome often leads to left ventricular hypertrophy. low adiponectin is best predictor of LVH!
○ mice with increased adiponectin show reduced adipocyte differentiation (creation into fat cells... I think! need to dig deeper on this)
○ mice with increased adiponectin show increased energy expenditure associated with mitochondrial uncoupling. (I am *very* interested in the mitochondrial uncoupling! this is like burning "free" kcal, roughly). STUDY LINK: https://academic.oup.com/endo/article/148/4/1539/2501482?login=false
○ adiponectin suppresses the metabolic derangements that may result in:
*type 2 diabetes [pubmed.ncbi.nlm.nih.gov/12436346/]
*obesity
*atherosclerosis [pubmed.ncbi.nlm.nih.gov/12611609]
*non-alcoholic fatty liver disease (NAFLD)
*risk factor for metabolic syndrome
[https://pubmed.ncbi.nlm.nih.gov/19258676]
○ Adiponectin in combination with leptin has been shown to completely reverse insulin resistance in mice.[https://pubmed.ncbi.nlm.nih.gov/11479627]
○ coronary artery disease has been found to be positively associated with high molecular weight adiponectin, but not with low molecular weight adiponectin.[https://pubmed.ncbi.nlm.nih.gov/20398150]
○ Adiponectin exerts some of its weight reduction effects via the brain. This is similar to the action of leptin (in factb adiponectin and leptin can act synergistically) [https://pubmed.ncbi.nlm.nih.gov/11479627]
○ Adiponectin promoted synaptic and memory function in the brain. Humans with lower levels of adiponectin have reduced cognitive function.[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340072]
○ Contrary to expectations, despite being produced in adipose (fat) tissue, adiponectin was found to be decreased in obesity (too many studies to list here). This downregulation has not been fully explained
○ Berberine, an isoquinoline alkaloid, has been shown to increase adiponectin expression, which partly explains its beneficial effects on metabolic disturbances. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788178]
○ Mice fed the omega-3 fatty acids (EPA and DHA) have shown increased plasma adiponectin. Curcumin, capsaicin, gingerol, and catechins also increase adiponectin expression.
○ adiponectin is low in Alzheimer’s [https://www.eurekalert.org/news-releases/538252]
○ Adiponectin reduces mitochondrial dysfunction (and reduces endothelial activation and pulmonary vascular injury) [https://faseb.onlinelibrary.wiley.com/doi/ftr/10.1096/fj.201901123R]