Hi y'all. Switching from tirz to reta

[CobraMcJingleballs]

Hi everyone,

Hoping to learn as much as I can about harm reduction and continuing this journey as responsibly and as informed as I can possibly be.

About me: Early 40s guy from SoCal. SW: 197, CW: 189, GW: 175-180. I've been on tirz 2.5mg/week for 6 weeks and have been steadily losing 1-1.5 lbs/week.

I'd otherwise be thrilled with this progress and the appetite suppression, except that I have little energy to get through my daily office job, let alone workouts.

I'm tracking calories and am at a deficit consistent semi-consistent with 1.25 lb/wk weight loss, but I've dieted on greater deficits before without the fatigue.

My sleep is dialed in, as is hydration, protein intake, sunlight, Vitamin D, micronutrients... I've pretty much tried to rule out every other variable that would be causing this fatigue.

So, despite tirz making it super easy to not eat (yet still ensuring I eat enough so that I "should" have sufficient energy), I'm switching to reta. I'm hoping the glucagon and other mechanisms of action help out.

Will keep my progress posted, but in the meantime, I'm absorbing as much info as I can. Thanks for providing this resource.

 

[ocuzuc]

Once I started on 10mg/week of tirz, I got fatigue. Got worse with 12.5mg and would doze off at my desk every afternoon. Tried eating more, less, energy drinks. Caffeine just made me jittery. My doctor suggested taking a few weeks break to see. By the 3rd week fatigue was gone. Restarted at 10mg, came right back. He gave me an Rx for 200mg of Provigil once/day in the morning. It’s been great, no nodding off, no jitters. I’d be interested in how it goes for you as I am considering Reta as well. But my doctor will not advise me on that journey, he has told me to do so would be malpractice.

 

[Calm Logic]

He gave me an Rx for 200mg of Provigil once/day in the morning. It’s been great, no nodding off, no jitters.

That is what I have been taking for my tirz fatigue and fatigue in general, though I get the meds from India. I have a supply of generic Provigil and generic Nuvigil, made by Sun Pharma. I like them since I don't get the jitters, and they are relatively safe for long-term use.

I was taking the stimulant clenbuterol for a little while since it is also used for fat burning and even muscle growth, but it can be riskier on the heart (since it is the opposite of a beta blocker). So I am getting albuterol tablets, which are not as strong/risky.