adverse effects of stopping GLP medications, as evidence suggests risks are associated with Weight cycling

I hate to say it... I agree. After being on sema, and stacking others, I had to stop for 8 weeks as I had scheduled surgeries.. one that got pushed back two weeks. I had stopped a few other times but for only a week or two due to surgeries and colonoscopies.

I was at my absolute lowest since I started this peptide journey. The noise came back full force. I was ravenous. I ate like I had not in 4 years. The holidays and having junk in the house has not helped. Thankfully I have only gained about 7 lbs but... I absolutely hate this. I "thought" I had my shit in check. I eat healthy, walk a lot, do some strength training.. but I don't deprive myself when I want something sweet.. I just eat a "normal" portion. Now? Once I start eating junk I just want more...

I have restarted what I was taking but low and slow. I do not want to get sick because I am eating like an asshole. I still think they are the answer but I am convinced I will be pinning something until the day I die...
"GLPs are for life"..... Learn it, live it, LOVE it.
 
This is my second new years on my 18 month GLP1 journey. I came off a months long stall with mounjaro. Went grey in 2025 and commenced Reta in September.

Three months on Reta, now at 7mg and I’ve dropped 14lbs. Hardly melting away. That’s because the smaller doses of Reta didn’t work for me and 6mg is where weight loss started happening again. As many here suggested and I am delighted with it.

Until…. I hit another stall. This is my third week of staying the same and I increased to 7mg. I was not prepared for how I’d feel hitting a 3 week stall not knowing when or if it will ending, how much that’s challenged my feelings about the journey ahead, and while I know it’s the long game I still have 50lbs to lose. It hits me right in the hope. Hard. Because even then I will still be classed by BMI as obese.

In this stall… I know something is up in my body, I feel it. I have pcos, a metabolic disorder, and I know from the appearance of odd symptoms something is out of whack in my hormones (erm hello 👋 is that you perimenopause 👀?). Make sense it would affect all my systems. But it will pass.

Long way of saying …. I think I know I will be on some form of this long term and I feel good and reassured about my 2 years of peptide freezer supplies.

I knew I would probably have to keep taking it to feel normal and keep the weight stable: I have accepted now there is something wrong with me that cannot be cured and will worsen again without helping myself using this treatment, combined with diet and ongoing exercise for health and self care.

Sending 💜love to @Laxfinity because as bad as I’m feeling, I’d be really depressed if I put 7lbs back on over the festive when it took me 7 dang months to lose it. Reading your story I thank you for sharing it because I feel for you! You will drop it again. Onwards we go!
I notice users of Reta usually also include stories of exercise along with the Reta. Triz just seems to work just by taking it. Also, this is my 3rd go around with Reta. I never got above 4mg a week before I gave up and went back in Triz. This time I will go to 12mg before I give up on it. If it doesn't work at 12mg/week, I will know it's just not for me.
 
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