adverse effects of stopping GLP medications, as evidence suggests risks are associated with Weight cycling

[Good-Heart6425]

Opinion | I No Longer Think GLP-1s Are the Answer

The drugs 'work' but may be working against us long-term

www.medpagetoday.com

 

[Laxfinity]

Opinion | I No Longer Think GLP-1s Are the Answer

The drugs 'work' but may be working against us long-term

www.medpagetoday.com

I hate to say it... I agree. After being on sema, and stacking others, I had to stop for 8 weeks as I had scheduled surgeries.. one that got pushed back two weeks. I had stopped a few other times but for only a week or two due to surgeries and colonoscopies.

I was at my absolute lowest since I started this peptide journey. The noise came back full force. I was ravenous. I ate like I had not in 4 years. The holidays and having junk in the house has not helped. Thankfully I have only gained about 7 lbs but... I absolutely hate this. I "thought" I had my shit in check. I eat healthy, walk a lot, do some strength training.. but I don't deprive myself when I want something sweet.. I just eat a "normal" portion. Now? Once I start eating junk I just want more...

I have restarted what I was taking but low and slow. I do not want to get sick because I am eating like an asshole. I still think they are the answer but I am convinced I will be pinning something until the day I die...

 

[tubby]

Was that doctor truly unaware of the muscle loss concerns prior to January of 2025 (date of the article)? And he also failed to understand that pharma viewed these drugs as a subscription plan rather than a cure? I'm not big on hurling insults around, but perhaps if he's been this hopelessly naive in the past, he should recognize his shortcomings and let others with better critical thinking skills author the contrarian articles of this sort. LOL

The article raises valid concerns. If one were paying full retail price ($1000+ per month in prior years), I can see where it might feel like extortion to have to keep paying that to maintain a stalled out weight loss and avoid regain, but I suspect many here aren't too worried about the financial aspect. The muscle-loss concerns are rather controversial as well with different studies showing different results in regards to body composition results and that likely varying across different formulations.

I think those who view GLP1's as first-line weight loss methods (while failing to address underlying food addiction issues or investigate their own relationship with food) may be disappointed, but like any other tool, these drugs have strong use cases for many people.