All right, i searched for freezing tirz, specifically the Jano response but...

[Calm Logic]

HGH is a peptide too but it so large that it is a protein, which is many times more likely to denature. So people on Meso would be the canary in the coalmine, and they are fine.

 

[Labcat]

HGH is a peptide too but it so large that it is a protein, which is many times more likely to denature. So people on Meso would be the canary in the coalmine, and they are fine.

That is a good general point! But peptides individuals can be very weird, in potentially being super stable or super unstable due to the amino acid residues and the folding structure stability.

 

[Calm Logic]

That is possible but unlikely when HGH is so fragile in comparison.

 

[Gr33dyOctopus]

I’m also searching for some hard data on that same question, but meanwhile, I recommend that you freeze that BAC vial to keep it longer than its own 30day cycle. ETA but not lower than 4.6F, it’s melting point. (Any chemists think this is unreasonable?)
I know the instructions say to keep it in at room temp, but maybe that is a problem with condensation getting pushed into the vial? Also lab freezers are -20C, which is below 4.6F.
And additional good move is to minimize pushing extra air into the vial since oxygen degrades benzyl alcohol. Benzyl alcohol itself degrades over time with alkaline (high) pH, oxygen, and exposure to its ozidation product, benzaldehyde, is my understanding, of course keeping an eye out for data about that as well.

I added all this because I’m trying in my own head to figure out what happens to the benzyl alcohol after you froze the peptide/BAC solution, perhaps gently make sure the benzyl alchol redissolves and gets mixed back in also if you are going to keep it in the fridge after and are relying on its bacteriostatic property.

As always, anyone with a mechanism that contradicts any of what I’m thinking, please do bring it up

 

[Gr33dyOctopus]

I’m also searching for some hard data on that same question, but meanwhile, I recommend that you freeze that BAC vial to keep it longer than its own 30day cycle. ETA but not lower than 4.6F, it’s melting point. (Any chemists think this is unreasonable?)
I know the instructions say to keep it in at room temp, but maybe that is a problem with condensation getting pushed into the vial? Also lab freezers are -20C, which is below 4.6F.
And additional good move is to minimize pushing extra air into the vial since oxygen degrades benzyl alcohol. Benzyl alcohol itself degrades over time with alkaline (high) pH, oxygen, and exposure to its ozidation product, benzaldehyde, is my understanding, of course keeping an eye out for data about that as well.

I added all this because I’m trying in my own head to figure out what happens to the benzyl alcohol after you froze the peptide/BAC solution, perhaps gently make sure the benzyl alchol redissolves and gets mixed back in also if you are going to keep it in the fridge after and are relying on its bacteriostatic property.

As always, anyone with a mechanism that contradicts any of what I’m thinking, please do bring it up

Everything I've ever read about this reccomends keeping bac water at room temp! Even tho it seems like it would make more sense to put it in the fridge at least.

 

[Gr33dyOctopus]

Most here don't freeze after recon. But most here don't filter either (and neither do I anymore).

Of course, it often comes down to risk tolerance, which generally increases over time.

Yep, thanks to Calm Logic im not filtering, tho I bought fucktons of filters. At some point maybe, but not convinced I need to, and yes risk tolerance is ramping up.since I've been here.

 

[Js351]

I think freezing reconstituted glp1’s is currently transitioning from being not advised to being seen as generally ok. That is why there is so much conflicting information out there. Just taking the pulse of this community and a few others, with the leaks from the test groups (I’m not a member). Generally advised if you do it, only do it once (one thaw cycle).

I personally see it as, which would I rather risk, a vial that is potentially destroyed from freezing, and doesn’t do anything, or a vial that is potentially contaminated because I kept it around 3 months instead of 1 (I’m talking greys here not compounded). I’m going to prefer to risk injecting something destroyed vs risking a contaminated vial every time. And the stuff is so cheap if I inject it and nothing happens I’ll just buy more.