Allergic reaction or Lipohypertrophy?

[Nothungry]

I’ve been on Reta since May 2025. I’ve always used hospira bac water and the same supplier (bff/binh). My husband and a couple family members are on it from the same supplier and batches and have had no problem. Since August I’ve been getting itchy welts that increase from quarter size to half a tennis ball. They last about 3 days. I usually inject in my stomach and try to space it out, but the isr’s have been getting worse. I tried it in my thigh and the same thing is happening. I was certain it was Lipohypertrophy until my thigh swelled. I haven’t injected in my thigh in a month. This seems like an allergic reaction to me. Wondering if anyone has experienced this and wondering if I should try a different supplier or if I should switch to tirz.

 

[zpped]

It happens. For me it was with Tirz, but my wife had it with Reta.

You can use a longer needle (1/2" into the shoulder worked for us) as it bypasses some of the immune response. Also rubbing the area with flonase before and after the injection.

Switching to a different peptide will almost certainly work but obviously not ideal.

Most people that stick it out say it goes away after a few months of it starting.

If the reactions become systemic (start getting hives in places you didn't inject) you should should switch to a different peptide.

 

[Nothungry]

It happens. For me it was with Tirz, but my wife had it with Reta.

You can use a longer needle (1/2" into the shoulder worked for us) as it bypasses some of the immune response. Also rubbing the area with flonase before and after the injection.

Switching to a different peptide will almost certainly work but obviously not ideal.

Most people that stick it out say it goes away after a few months of it starting.

If the reactions become systemic (start getting hives in places you didn't inject) you should should switch to a different peptide.

Thank you, your response. That is so helpful. So is the shoulder injection intramuscular then?

 

[zpped]

Thank you, your response. That is so helpful. So is the shoulder injection intramuscular then?

1/2 is enough for a very shallow IM for most people.

 

[Nothungry]

1/2 is enough for a very shallow IM for most people.

Is that safe and effective?

 

[zpped]

Is that safe and effective?

It's definitely effective. Both for the medication and usually for preventing the ISR you are describing.
Safe is for you to decide. Injecting black market drugs is already beyond most people's definition of safe.
You are purposely bypassing a portion of your immune system though. Are you good about your antiseptic procedures? How do you feel about filtering?

 

[ZippityDooDah]

The tirz clinical trials found a certain percentage of participants developed an allergy to it over time, so it wouldn't surprise me if that carries over to reta and other GLP's. At the same time, as best as I can recall none of the reactions were classified as serious or severe to the point that they were required to include any kind of warning about it.