Any stack recommendations for adults 65 and older?

[EAM9112]

Looking for a peptide stack for my parents to support general health. I was thinking Wolverine and something like adamax for cognitive function. Curious to hear everyone’s experiences.

 

[Diamondd817]

KLOW & NAD+ might be a good start.

 

[EAM9112]

KLOW & NAD+ might be a good start.

Do you recommend a full SS-31 and Mots C protocol prior to NAD? I have never taken NAD myself but I have read it is most effective with the SS and Mots.

 

[Lloyd]

I would recommend Semax

 

[ultima thule]

How about Epithalon? I'm a bit younger (49) but gave it a try just for a longevity purpose...

 

[Researcher6076]

I am older than your parents. But you've got to move beyound age to their symptoms and goals. We're all indoviduals. Are they overweight? Cancer risks? chronic conditions? FWIW, here is my stack, but probably a nit more that your parents are looking for.

As with any stack, the foundation has to be sleep, nutrition, reisitance training. If you parents are doing those, some peptides and supliments might help them, towards their goals. But, they have to get those right as a foundation for peptides to help.

Function	Name	Dose	Frequency	Pattern
Metabolic	Tirzepatide	SC 1.5 mg	Weekly (Sunday)	Continuous
Retatrutide	SC 1.5 mg	Weekly (Wednesday)	Continuous
Metformin	PO 500 mg	Daily	Continuous
GH axis	Ipamorelin + CJC‑1295 no‑DAC	SC 200 mcg + 200 mcg	Sun–Thu PM (fasted)	12 weeks on / 6 weeks off
Tesamorelin + Ipamorelin	SC 2 mg + 200 mcg	Mon-Fri AM (fasting)
Tissue repair	GHK‑Cu	SC 1 mg	Daily	Continuous
BPC‑157	SC 200 mcg	2× weekly	Continuous
Zinc Picolinate	PO 50 mg	3× weekly	Continuous
Anti‑inflammatory	KPV	SC 750 mcg	Daily	Continuous
Omega‑3	PO DHA 900 mg; DPA 140 mg	Daily	Continuous
Immune modulation	Thymosin‑α1	SC 1.6 mg	Weekly (Sunday)	Continuous
Longevity	Epitalon + Crystagen + Pinealon	SC 5 mg/day; 0.5 mg/day; 0.5 mg/day	Daily for 10 days	Annually, other peptides paused except GLP‑1s
Prostrate support	Prostamax (KEDP)	SC 0.5 mg/day	Daily for 10 days	Annually
Beta Sitosterol	PO 250 mg	Daily	Continuous
Neurotrophic	Semax	IN 600 – 900 mcg	Daily	2-4 weeks on / 4–8 weeks off
Sleep support	L-Glycine	PO 3000 mg	Daily 1 hr before bed	Continuous
Cellular energy & Brain support	NMN (β‑Nicotinamide Mononucleotide)	PO 1000 mg	Daily	Continuous
Apigenin	PO 200 mg	Daily	Continuous
Acetyl‑L‑Carnitine (ALCAR)	PO 1000 mg	Daily	Continuous
Beta‑Alanine	PO 3000 mg	Daily	Continuous
Creatine HCl	PO 1500 mg	Daily	Continuous

 

[Calm Logic]

Dr. Lee’s “Top 3 Peptides:”

BPC-157 – healing, gut repair, systemic anti-inflammatory.

Thymosin Alpha-1 – immune system support, anti-cancer, anti-viral.

Epitalon – longevity, gene regulation, pineal reset.

View: https://youtu.be/qnnq_-YL8dk?si=z2paSDTQwz9CWZ5j

The video introduces Dr. Edwin Lee as a doctor who specializes in functional and regenerative medicine, with a strong focus on peptide therapy. He is also noted as a co-founder of the Clinical Peptide Society and has authored books on the topic, such as The Fountain of Youth with Peptides.

Epithalon: Dr. Lee describes this as his favorite bioregulator for longevity. It is naturally produced by the pineal gland, and as we age, its production decreases, causing cells to get stuck in the G2 phase of the cell cycle. Epithalon is said to turn on cell cycle activity, helping with self-replication, improving sleep by resetting melatonin production, and potentially reversing markers of biological aging (13:01 - 14:33; 23:45 - 24:12).

Thymosin Alpha-1: This peptide is highlighted for its role in supporting the immune system. As the thymus gland shrivels with age (a process known as immunosenescence), the immune system becomes less effective at fighting infections and cancer. Supplementing with Thymosin Alpha-1 is suggested to help rejuvenate immune function (4:02 - 5:13; 21:19 - 22:06).

BPC-157: Often referred to as the "Wolverine peptide," it is recommended for its powerful ability to reduce inflammation and accelerate the healing of tissues, joints, and tendons, which often become more susceptible to injury with age (7:13 - 11:07; 20:06 - 20:52).

Mitochondrial Peptides (MOTS-c and SS-31): For age-related energy decline caused by mitochondrial dysfunction, the video suggests MOTS-c to enhance mitochondrial performance and SS-31 to help maintain the structural integrity of the mitochondria (36:30 - 43:27).

Attached are lifestyle modifications in place of (or in addition to) taking Epithalon to naturally increase levels of Epithalamin. PDF is by Google Gemini.

 

[Researcher6076]

Dr. Lee’s “Top 3 Peptides:”

BPC-157 – healing, gut repair, systemic anti-inflammatory.

Thymosin Alpha-1 – immune system support, anti-cancer, anti-viral.

Epitalon – longevity, gene regulation, pineal reset.

View: https://youtu.be/qnnq_-YL8dk?si=z2paSDTQwz9CWZ5j


Attached are lifestyle modifications in place of (or in addition to) taking Epithalon to naturally increase levels of Epithalamin. PDF is by Google Gemini.

I do use the Epitalon reset myself. But the evidence is so thin it is almost non-existent. It has a good safety record, and some mechanistic plausibility, so heck, why not try it? But, no way it should be in the top 3.

Ta1, I agree has a real application for supporting aging. Most seniors have immune decline and once weekly 1.6mg Ta1 can likely help.

BPC-157 is worth considering, but only after a serious discussion around cancer risks. BPC-157 is absolutely contraindicated for active or recent malignancies and is highly cautioned for subjects at elevated cancer risk. Cancer risk increases with age.

KPV is almost a no brainer. It should be in the top 3 for sure. It is gentle, is widely used so we can infer safety, and it really helps with inflammation. Most seniors have inflammation.

I would consider a low dose of Retatrutide unless the subjects are below weight. Most seniors are no below weight. It has all kinds of protective effects, including reducing cholesterol due to glucagon activation; it literally encourages the body to burn lipids.

It isn’t a peptide, but unless contraindicated due to some individual condition, get them on 500 mg of Metformin. It helps stabilize blood sugar and it is an AMPK activator, so it improves mitochondrial function. (Google metformin for longevity and you will find mainstream research.)

And there are some simple supplements that almost every senior should be taking that support metabolism, energy and cognition: Omega-3, NMN, Apigenin, Acetyl‑L‑Carnitine, Beta‑Alanine, and Creatine HCl.

RE the video… it is frustrating as heck that videos and podcasts present information as authoritative when they clearly haven’t even done minimal study.