Anyone thinking of switching to oral in maintenance?

[Peptidase]

As we know, Rybelsus is in investigation (at higher doses) for weight management. Some of the trials have shown up to 15% weight loss after 68 weeks.
Orfoglipron from the flower company has shown weight loss of almost 15% after 36 weeks and it looks like some more data readouts will be coming out this year. Anyone thinking of moving to a once daily oral pill when they become available for maintenance instead of injecting every week?
Have a pretty decent stack of the relevant peps that should last for years but sometimes it's tempting to think of how great/convenient it would be to go with once daily oral drugs that have similar effectiveness or close to similar effectiveness as the injectables, especially if in maintenance where continuing to lose weight is not the goal.

 

[Garbo]

As we know, Rybelsus is in investigation (at higher doses) for weight management. Some of the trials have shown up to 15% weight loss after 68 weeks.
Orfoglipron from the flower company has shown weight loss of almost 15% after 36 weeks and it looks like some more data readouts will be coming out this week. Anyone thinking of moving to a once daily oral pill when they become available for maintenance instead of injecting every week?
Have a pretty decent stack of the relevant peps that should last for years but sometimes it's tempting to think of how great/convenient it would be to go with once daily oral drugs that have similar effectiveness or close to similar effectiveness as the injectables, especially if in maintenance where continuing to lose weight is not the goal.

Love this thought-provoking question.

I've been in "maintenance" for a long time, and seem to accidentally accumulated years' and years' worth of tirz and sema

But yeahhhh .... if there was a magic swallowable pill, I can well imagine how desirable that would be in terms of convenience, time, paraphernalia, storage, privacy etc etc etc.

AMENDING MY REPLY because I came back and found @FrankTdog's comment and 100% agree that I would not put up with all the requirements on taking those pills as they exist now. I'm with you, dog of Frank T

 

[keangkong]

As we know, Rybelsus is in investigation (at higher doses) for weight management. Some of the trials have shown up to 15% weight loss after 68 weeks.
Orfoglipron from the flower company has shown weight loss of almost 15% after 36 weeks and it looks like some more data readouts will be coming out this week. Anyone thinking of moving to a once daily oral pill when they become available for maintenance instead of injecting every week?
Have a pretty decent stack of the relevant peps that should last for years but sometimes it's tempting to think of how great/convenient it would be to go with once daily oral drugs that have similar effectiveness or close to similar effectiveness as the injectables, especially if in maintenance where continuing to lose weight is not the goal.

If I had successfully lost weight and reached a point where I didn't want to lose any more, I'd simply stop increasing the dose, or reduce the dose if still losing. Just because a medicine generally works well doesn't mean that it will work for me. I'd stick with what had worked for me. Tried and true beats slightly more convenient.

I stand willing to revise my opinion as we learn more about these new medicines.

 

[FrankTdog]

*For me*, doing a once a week shot is less work / complicated that taking the oral. It has to be taken on an empty stomach in the morning with water (up to 4 ounces of water), no other liquids besides water and then wait at least 30 minutes before eating food, drinking beverages or taking other oral medications. I am not that organized when I roll out of bed and coffee time is not waiting 30 minutes...

 

[chrisdfw]

I do not think Orfoglipron has the same dosage complications. I am looking forward to it showing up on the gray market.

 

[m100568]

I have multi-year peps in storage, so I probably wouldn't consider until then.

My first consideration is the composition of Orforglipron. My understanding is that it is GLP-1 only. So, kind of like Ozempic side effects? I don't know if I want that lump in my stomach feeling for the rest of my life. I kind of like Reta. You have some appetite and can enjoy food, but you don't eat much and you can maintain your weight. I think I could do that for a long time.

Another consideration is would there be even better peps out there by the time I work through my stored peps? I'm always open to even better peps.

My final consideration is coverage by Medicare. I will be on it by the time I run out of my stored peps. Would Medicare pay most or all of the costs of Orforglipron? That might be tempting.

So, overall, I would have to wait and see. I don't think I can decide at this point in time.