Anyone trial >12 mg Reta or stalled on high dose reta?

[catdog]

Hey all,

For some background, I've been on GLPs for >1.5 yrs. Started on Tirz, maxed out and stalled at 15mg. Switched to reta about 3 months ago and am currently at Reta 10mg. On my switch I regained about 10 lbs but reduced 3 of those lbs on reta so far. So net -7 lbs. Just wondering how people have done on Reta high dose? Has anyone stalled? Has anyone tried higher dose than 12mg? I know research wise that is uncharted, but was just curious.

Thanks all!

 

[GLP1Pharmacist]

I am at 12 with good results and may go to 15mg if I need to.

 

[rkl123]

15

 

[Sassypeptide]

Oh man, this makes me not even want to try Reta. I’m n 18mg Tirz and have been stalled for months and it’s not as effective anymore, definitely don’t wanna go through another transition just to be maxed out again 🫤

 

[HoopFan]

Oh wow! Nope. Not I. I just bumped to 6mg Tirz. I’m near goal now. Moving to Reta soon, after I kill off the remaining Tirz. Would like to see if I can start eating more and see how Reta does for when I start lifting again.

 

[catdog]

I am at 12 with good results and may go to 15mg if I need to.

Good to know. How much are you losing per week? Were you GLP naive prior to starting Reta?

 

[catdog]

15

How long have you been at 15mg? Were you at 12 for a while? Are you still losing at 15?

 

[catdog]

Oh man, this makes me not even want to try Reta. I’m n 18mg Tirz and have been stalled for months and it’s not as effective anymore, definitely don’t wanna go through another transition just to be maxed out again 🫤

I wouldn’t let this discourage you. I’m not maxed on Reta yet, just was curious preemptively. I don’t regret switching honestly

 

[GLP1Pharmacist]

Good to know. How much are you losing per week? Were you GLP naive prior to starting Reta?

Sema brand name then tirzepatide compounded, then Reta when I found gray market.

Average 1-2 lbs a week, down over 100lbs.

 

[catdog]

Sema brand name then tirzepatide compounded, then Reta when I found gray market.

Average 1-2 lbs a week, down over 100lbs.

Amazing work. That’s great to hear. Probably great things to come hopefully for me haha

 

[rkl123]

How long have you been at 15mg? Were you at 12 for a while? Are you still losing at 15?

~1.5 months. Very slowly but I'm near goal.

 

[catdog]

~1.5 months. Very slowly but I'm near goal.

Thats great, notice any big difference between 12 and 15 mg?

 

[rkl123]

Im

Thats great, notice any big difference between 12 and 15 mg?

I’m a moderate Reta underresponder. But I have better side effects with it than with tirz. So I hardly felt suppression until like 10ish. 12 feels decent, 15 feels better. Both are still weaker than 5 of tirz was for me lol.

 

[rsmith]

Does anyone have a copy of the graph that lists and compares different amounts of GLP-1, GIP and Glucogon in the 3 primary weight-loss peptides (Sema, Tirz, Reta)???

Please?

 

[Calm Logic]

Someone posted the table above in the survo subforum here. I verified most of the KI values before as being what is in the research literature:

WBS

I really hope so, thank you friend 😁 🙏 Welcome but where can we find the JYC screwup? Didn't see it here or on STG. I screenshot and post I mean it was posted publicly and were looking after our own. If nothing else when was the test performed for jyc? Not sure why there's not an uproar here...

glp1forum.com

But for survo, all I know for sure is the 8:1 ratio between GLP and glucagon was mentioned in the research.

Very different GLP estimates for maz and survo from a different table on TG:

 

[rsmith]

Exactly what I'm looking for. Thanks Calm.

 

[lessthanhalf]

I have seen 2 different GIP binding affinities for tirz and reta, one shows tirz being stronger ( lower ki ) and the other the opposite. As both these peptides have a long fat molecule attached to them they strongly bind to albumin, so nearly all of the drug in the bloodstream exists bound to this protein, which alters the way they interact with receptors and gives them the week or so long half lives. So some of the ki numbers are for the drugs bound to albumin and some are not. My reading and pharmacology are not quite good enough to be certain which actually has the stronger effect on gip receptors, but probably tirzepatide. for glp-1 tirz is stronger either way, and semaglutide much stronger.

 

[rsmith]

PubMed Central Image Viewer.

Dose–response effects on HbA1c and bodyweight reduction of survodutide, a dual glucagon/GLP-1 receptor agonist, compared with placebo and open-label semaglutide in people with type 2 diabetes: a randomised clinical trial - PMC

The aim of this study was to assess the dose–response effects of the subcutaneous glucagon receptor/glucagon-like peptide-1 receptor dual agonist survodutide (BI 456906) on HbA1c levels and bodyweight reduction. This Phase II, multicentre, ...

pmc.ncbi.nlm.nih.gov

Here, survo significantly outperformed Sema on head-to-head comparisons for blood glucose and weight loss. However, the tested Sema dose never exceeded 1 mg./week so I'm not sure it's a fair comparison. Moreover, the study doesn't appear to cast light on whether outcomes resulted from Glucagon or GLP-1 factors although it's implied that the Glucagon agonist was responsible.

 

[rsmith]

GLP-1 single, dual, and triple receptor agonists for treating type 2 diabetes and obesity: a narrative review - PMC

Obesity and type 2 diabetes mellitus (T2DM) present major global health challenges, with an increasing prevalence worldwide. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as a pivotal treatment option for both conditions, ...

pmc.ncbi.nlm.nih.gov

Treatment algorithm for obesity (I don't understand why Reta wasn't included under NASH):

 

[BooneDonk]

GLP-1 single, dual, and triple receptor agonists for treating type 2 diabetes and obesity: a narrative review - PMC

Obesity and type 2 diabetes mellitus (T2DM) present major global health challenges, with an increasing prevalence worldwide. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as a pivotal treatment option for both conditions, ...

pmc.ncbi.nlm.nih.gov

Treatment algorithm for obesity (I don't understand why Reta wasn't included under NASH):


View attachment 8535

Flow chart lives matter!

For the green rectangles, they should approve 3mg Reta every 72hrs as effective.