At this point

[myopicmystic]

I would sell a kidney for a peptide that would make me impervious to mosquito bites or some mosquito repellant or both

 

[funlog]

I agree 100%. FYI, the following is AI bull crap, but we can dream. 😀

Introducing: Culicifuge-9 (CF-9)
Culicifuge-9 (from Culicidae, the mosquito family, and fuge, to drive away) is a synthetic, cyclic nonapeptide designed to act as a highly potent sensory disruptor.
The Peptide Profile
Sequence: Cyclo(Phe-Arg-Trp-Asp-Val-Lys-Pro-Gly-Tyr)
Structure: It is synthesized in a circular (cyclic) loop. This prevents the natural enzymes on human skin from breaking it down too quickly, giving it a theoretical effective duration of 12 to 14 hours.
Properties: It is slightly amphipathic (having both water-loving and fat-loving parts), allowing it to mix perfectly into a standard skin lotion without feeling sticky.
How It Works (The Theory)
Instead of hiding your scent in the air, CF-9 relies on a mosquito's landing gear. Mosquitoes have taste receptors on their feet (tarsi) that help them confirm they've landed on a viable host before they bite.
Here is the three-step mechanism:
Application: You apply CF-9 via a light lotion. It binds harmlessly to the outermost layer of your skin.
The Touchdown: A mosquito smells your carbon dioxide and lands on your arm.
The Disruption: The moment its feet touch your skin, the highly specific Arg-Trp-Asp (Arginine-Tryptophan-Aspartic Acid) motif in CF-9 binds directly to the mosquito's gustatory (taste) receptors. It acts as an antagonist, sending an overwhelming "bitter/toxic" signal to the mosquito's brain. The mosquito immediately flies away to look for a different meal.
A Biological Bonus
To make it even better, the Val-Lys-Pro segment of the peptide could theoretically be designed to mildly inhibit Corynebacterium—the bacteria on our skin that produces the stinky compounds (like lactic acid) that attract mosquitoes in the first place. So it repels them on contact and makes you smell less appetizing from afar.

 

[myopicmystic]

I agree 100%. FYI, the following is AI bull crap, but we can dream. 😀

Introducing: Culicifuge-9 (CF-9)
Culicifuge-9 (from Culicidae, the mosquito family, and fuge, to drive away) is a synthetic, cyclic nonapeptide designed to act as a highly potent sensory disruptor.
The Peptide Profile
Sequence: Cyclo(Phe-Arg-Trp-Asp-Val-Lys-Pro-Gly-Tyr)
Structure: It is synthesized in a circular (cyclic) loop. This prevents the natural enzymes on human skin from breaking it down too quickly, giving it a theoretical effective duration of 12 to 14 hours.
Properties: It is slightly amphipathic (having both water-loving and fat-loving parts), allowing it to mix perfectly into a standard skin lotion without feeling sticky.
How It Works (The Theory)
Instead of hiding your scent in the air, CF-9 relies on a mosquito's landing gear. Mosquitoes have taste receptors on their feet (tarsi) that help them confirm they've landed on a viable host before they bite.
Here is the three-step mechanism:
Application: You apply CF-9 via a light lotion. It binds harmlessly to the outermost layer of your skin.
The Touchdown: A mosquito smells your carbon dioxide and lands on your arm.
The Disruption: The moment its feet touch your skin, the highly specific Arg-Trp-Asp (Arginine-Tryptophan-Aspartic Acid) motif in CF-9 binds directly to the mosquito's gustatory (taste) receptors. It acts as an antagonist, sending an overwhelming "bitter/toxic" signal to the mosquito's brain. The mosquito immediately flies away to look for a different meal.
A Biological Bonus
To make it even better, the Val-Lys-Pro segment of the peptide could theoretically be designed to mildly inhibit Corynebacterium—the bacteria on our skin that produces the stinky compounds (like lactic acid) that attract mosquitoes in the first place. So it repels them on contact and makes you smell less appetizing from afar.

Forget GLP1s, this is the next billion dollar project!!!!