Auto immune and Tirz plus Reta discussion

[tracylynn]

Short story for joint pain - I'm on 8mg of Reta. I'm considering adding a low dose of Tirzep to see if it can help more with joint pain.

Details - I was on Tirzepatide for 6 months and had such an amazing impact on my auto immune disease. Giving me so much relief for inflammation, arthritis, and joint pain. Of course it brought my cortisol levels down really quickly and plus I lost 40 lbs.
Unfortunately, I could no longer get it from my local compound pharmacy and I had to come off of it. That is when I started getting into other peptides and the grey market.

Fast forward 4 months, I had decided to give Reta, LipoC, and KLOW a try. I'm finally on 8mg a week of Reta (2nd week of 8mg felt like it kicked in) but not seeing improvement on the joint pain and swelling. To me it doesn't work like Tirz so I still have a bit of food noise too. Not losing weight but not gaining.
My focus is more about getting relief from the pain and feeling better. I just wonder if there is a reason I shouldn't try a low does of Tirz in the middle of the week to see if it can help my auto immune issues.

Thoughts?

 

[dogmom]

Tirz and Reta did nothing for my rheumatoid arthritis. The only thing that helped me was a biologic, Enbrel. And it took about 3 months of Enbrel to feel the difference. So if you are having a lot of joint pain you may want to consider that.

 

[Calm Logic]

just wonder if there is a reason I shouldn't try a low does of Tirz in the middle of the week to see if it can help my auto immune issues.

Sounds fine to me. People do it and seem fine.

This is where I go off a cliff though:

Maybe the GLP aspect of the tirz was helping you the most for your inflammation? Though GIP is anti-inflammatory too, with synergistic effects. At least for you so far, the glucagon aspect of reta may be not as helpful or could even be slightly counterproductive.

 

[joseblo]

Hmmm... this is good (or bad) information for me since I'm just starting the switch to reta from compounded tirz. One of the things I like most is the anti-inflammatory effects since I'm basically at GW. I had assumed the GIP was doing the job, but reading up on it, looks like the cytokine (non-gut) effects are more pronounced for GLP1. Well, hopefully my research turns out well, and this new knowledge doesn't require blinding. I guess I'll just shut my eyes when I do it and see if that helps.

 

[tracylynn]

Sounds fine to me. People do it and seem fine.

This is where I go off a cliff though:

Maybe the GLP aspect of the tirz was helping you the most for your inflammation? Though GIP is anti-inflammatory too, with synergistic effects. At least for you so far, the glucagon aspect of reta may be not as helpful or could even be slightly counterproductive.

Interesting. What would make it counterproductive? Or when you say counterproductive do you think it can actually make it a little worse?

Seems like I came across someone else saying it was not good for auto immune but I did not see the source as a reliable source. Now I'm wondering if they are right. Maybe I need to go back to Tirz.

 

[tracylynn]

Tirz and Reta did nothing for my rheumatoid arthritis. The only thing that helped me was a biologic, Enbrel. And it took about 3 months of Enbrel to feel the difference. So if you are having a lot of joint pain you may want to consider that.

I've spent several years trying different ones, going down the whole biologic path, and I'm still currently on one but it's never helped with out me adding all kinds of other meds like prednisone, over the counter pain meds, or sometimes prescription pain meds....it's been a journey. Then I got on Triz and I no longer needed anything else but the weekly injection and the biologic every 8 weeks. My goal is to get back to that because now I'm having flair ups again. 🙁

 

[tracylynn]

looks like the cytokine (non-gut) effects are more pronounced for GLP1.

I need to do more research because I didn't know this. Make sense though.

 

[Calm Logic]

Interesting. What would make it counterproductive? Or when you say counterproductive do you think it can actually make it a little worse?

Seems like I came across someone else saying it was not good for auto immune but I did not see the source as a reliable source. Now I'm wondering if they are right. Maybe I need to go back to Tirz.

It's more in theory since reta was designed to balance all that out.

But speculation with Google Gemini:

It's possible that the systemic metabolic changes induced by strong GCGR activation could, in some individuals, alter the delicate balance of inflammatory mediators, leading to or exacerbating joint pain. The precise nature of this interaction is not fully understood, and more research would be needed to confirm it.

 

[amynurse]

The 2 that help my RS's joint pain the most are AOD9604 and Cartalax. As far as reduction in inflammation, nothing beats tirz.

 

[Thistley]

Great to hear that you found an anti inflammatory effect! I’m always curious to hear how Tirz has these effects for people. I suppose I have noticed a reduction in joint pain ( MJ for 13 months & 4 months mostly plateau at 15mg) so researching impact of Reta on breaking the maintence stall but put that down to taking the weight off rather than the effect of Tirz.

I’m curious as to why you felt like making the move to Reta instead of sourcing and continuing your Tirz journey.

 

[lessthanhalf]

Just on the basis of your previous experience it would be logical to swap back to tirzepatide, if you arthritis was well controlled on it , then there is at least a good chance it was responsible. Autoimmune disorders do tend to fluctuate up and down in severity for no obvious reasons, so it possible it was just coincidence it got better on tirzepatide. I don't think there is much in the way of substantial research yet on glp medications effect on autoimmune diseases, but what I have seen suggests a possible benefit. I cannot think of any good reasons why reta would be less effective than tiz but again I do not think anyone has a comprehensive understanding of the effects of these medications on the immune system. It is not a dangerous or expensive experiment at chinese prices, and if it might reduce pain and the need for complex medications, it would make sense to go back to it. Worst case scenario is it is slightly less effective than reta for weight loss and does not help much, but given that it seemed to work before it would make sense to try it again.

 

[50ShadesGreyMarket]

Short story for joint pain - I'm on 8mg of Reta. I'm considering adding a low dose of Tirzep to see if it can help more with joint pain.

Details - I was on Tirzepatide for 6 months and had such an amazing impact on my auto immune disease. Giving me so much relief for inflammation, arthritis, and joint pain. Of course it brought my cortisol levels down really quickly and plus I lost 40 lbs.
Unfortunately, I could no longer get it from my local compound pharmacy and I had to come off of it. That is when I started getting into other peptides and the grey market.

Fast forward 4 months, I had decided to give Reta, LipoC, and KLOW a try. I'm finally on 8mg a week of Reta (2nd week of 8mg felt like it kicked in) but not seeing improvement on the joint pain and swelling. To me it doesn't work like Tirz so I still have a bit of food noise too. Not losing weight but not gaining.
My focus is more about getting relief from the pain and feeling better. I just wonder if there is a reason I shouldn't try a low does of Tirz in the middle of the week to see if it can help my auto immune issues.

Thoughts?

Have you looked into BPC-157 for inflammation, which addresses joint pain? I have personal success with it in addition to the research and anecdotal evidence available. I backed up my results with a Cortisol test (saliva).

Another I’ve found to work is SS31/Mots-c - you can get it synthesized here in the US, in fact the lab I use is right here in Houston, TX. They give you the COA and endotoxin report as well.

There are also Thymic peptides - I have personal experience with Alpha-1 and Beta-2 - if you are dealing with autoimmune, there’s a long list of peptides depending on the mechanism.

 

[Calm Logic]

Another I’ve found to work is SS31/Mots-c - you can get it synthesized here in the US, in fact the lab I use is right here in Houston, TX. They give you the COA and endotoxin report as well.

How much do they charge compared to China?

 

[50ShadesGreyMarket]

How much do they charge compared to China?

The only thing I’ve ever ordered from China was Reta and Sema, everything else I’ve sourced from a medical doctor (prescription) and local pharmacies or had them synthesized.

The first setup fee for 4 peptides was a little over $20K, without going into too much detail, I didn’t foot the entire bill myself. The amount produced was more than I could justify storing, however it comes with guaranteed purity.

For comparison: Reta costs $.07/mg to manufacture, you can order it on the grey market for $.32/mg, you can get it from a compounding pharmacy (incl. dr visit/prescription) for $12.62/mg or have it synthesized for well over $100/mg. It makes sense to synthesize peptides that are not available from reputable sources or that are obscure enough that there’s no market for, but weight loss is what’s driving the current peptide craze and there’s plenty of supply to meet those demands.