I will tell you my experience from a couple of days ago with them. I asked them if they shipped from the US or China and they said they have a fully stocked warehouse in the US and named a bunch of glp-1s and others. I said great, so I made the order and paid, then they came back and said because of the demand they are not in stock and will be shipped from China. Said it could take 3 to 4 weeks. 🤷♂️. I cant say if it is legit or not but take it for what it's worth. I know it can be difficult finding a vendor. I'm still exploring as well. This has been a great group of people here though!!I found it odd that they just created a new url and all there products are on sale?
Don't think these are the original sellers.
Not the first time for them. Typical Chinese peptide company regarding customer service, as in barely any.I will tell you my experience from a couple of days ago with them. I asked them if they shipped from the US or China and they said they have a fully stocked warehouse in the US and named a bunch of glp-1s and others. I said great, so I made the order and paid, then they came back and said because of the demand they are not in stock and will be shipped from China. Said it could take 3 to 4 weeks. 🤷♂️. I cant say if it is legit or not but take it for what it's worth. I know it can be difficult finding a vendor. I'm still exploring as well. This has been a great group of people here though!!
Actually I've learned alot just from reading your previous posts. Much respect. 🙏Not the first time for them. Typical Chinese peptide company regarding customer service, as in barely any.
Yes Dear Calm. Trust me private. 😜Not the first time for them. Typical Chinese peptide company regarding customer service, as in barely any.
Yeah just looking for a reta source and come upon them its my first time looking for a glp-1 source.They are known for always being on sale and creating a new url multiple times per year. But good instincts to be suspicious.
Yeah hoping the best for you, from the sound of other users on this thread there saying its fine.I will tell you my experience from a couple of days ago with them. I asked them if they shipped from the US or China and they said they have a fully stocked warehouse in the US and named a bunch of glp-1s and others. I said great, so I made the order and paid, then they came back and said because of the demand they are not in stock and will be shipped from China. Said it could take 3 to 4 weeks. 🤷♂️. I cant say if it is legit or not but take it for what it's worth. I know it can be difficult finding a vendor. I'm still exploring as well. This has been a great group of people here though!!
Sounds great update me!I just placed my first order with them on 5/22, should get it tomorrow. Guess we will find out.
Yeah it seems Bfflist has a good reputation but I was just wondering if the Bfflist.org were the original sellers.If you look at the various Telegram and Discord groups, you will find of all the Chinese vendors Bfflist has perhaps the most third party testing, and pretty consistently positive results too.
I have used them myself, not the cheapest but reliable with good service.
Of course this can change rapidly from a reliable to dodgy vendor, as we have seen.
So i should be good to buy from bfflist.org?They always change their site. I had my last order from there arrive in 3 days.
That's entirely up to you to decide.So i should be good to buy from bfflist.org?
I used PayPal on their Alibaba pay.So i should be good to buy from bfflist.org?
And I saw they take alibaba pay, is it card?
I really don't think that they are run of the mill resellers. Their vials and packaging have a unique look and their lyophilized peptide itself has a very distinctive look with crumbly pucks that no other vendor I'm aware of has. They also have had a lot of stinging issues in the past which is unique in how common it was for them. There's a pretty strong case for them actually being a finisher, ie buying raw peps and lyophilizing them. That, or they are sole sourcing from a finisher.They are almost certainly resellers.
Yes they are notorious for broken pucks. I haven’t had stinging for their Reta or Cagri thoughI really don't think that they are run of the mill resellers. Their vials and packaging have a unique look and their lyophilized peptide itself has a very distinctive look with crumbly pucks that no other vendor I'm aware of has. They also have had a lot of stinging issues in the past which is unique in how common it was for them. There's a pretty strong case for them actually being a finisher, ie buying raw peps and lyophilizing them. That, or they are sole sourcing from a finisher.
Long story very short, no. Best theory I've seen is a mismatch in osmolarity.Did anyone ever get to the bottom of the stinging? I am on their Tirz and it stings moderately for an hour or two after pinning. I am a big boy and can cope fine but it does make you wonder...
Just bought a kit of Reta any tips? I thought about freezing should i? Or keep it in the fridgeLong story very short, no. Best theory I've seen is a mismatch in osmolarity.
Haven't heard any new issue with stinging in a while though. Tirz does fine with bacteriostatic sodium chloride water, so maybe try that and see if it helps. (It's a saline mixture that is closer to your bodies composition.)
Google Gemini said:The general consensus to freeze freeze-dried retatrutide is well-founded, as lower temperatures generally improve stability and prevent degradation. Here's an evaluation of the points raised:
Advantages of Freezing Freeze-Dried Retatrutide:
Concerns about Freeze-Thaw Cycles (and why they are less critical for freeze-dried powder):
- Minimizing Moisture and Degradation: The primary reason for freezing freeze-dried peptides is to further minimize moisture content and reduce the rate of chemical degradation. Even after freeze-drying, some residual moisture can remain. Colder temperatures significantly slow down chemical reactions, including hydrolysis and oxidation, which are major degradation pathways for peptides.
- Preventing Sterility Problems: While freeze-drying itself removes most water, which inhibits microbial growth, complete dryness is crucial for long-term sterility. Any remaining moisture, especially at higher temperatures, could potentially allow for microbial proliferation over time. Freezing further reduces water activity to negligible levels, creating an environment where microorganisms cannot grow.
- Long-term Stability: Peptides in powder form are generally much more stable than in solution. Storing them at -20°C or even -80°C can extend their shelf life from months to years, preserving their purity and biological activity.
The concern about "freeze-thaw cycles" is primarily relevant for solutions of peptides or proteins, not typically for completely freeze-dried powders. Here's why:
Practical Considerations:
- Mechanism of Damage in Solutions:
- Ice Crystal Formation: When solutions freeze, ice crystals form. These crystals can physically damage protein structures, cause aggregation, and concentrate solutes (freeze concentration), leading to localized stresses on the peptide.
- Oxidative Stress: Freeze-thaw cycles can induce oxidative stress, generating reactive oxygen species that can damage peptides.
- Denaturation: The repeated freezing and thawing process can lead to irreversible denaturation or unfolding of proteins, leading to loss of activity.
- Why it's less of a concern for freeze-dried powder:
- Absence of Bulk Water: In a properly freeze-dried powder, the vast majority of water has been removed. There's no bulk liquid phase to form large ice crystals or concentrate solutes in the same damaging way as in a solution.
- Amorphous State/Vitrification: Freeze-drying often creates an amorphous, glassy solid (vitreous state) where the peptide molecules are essentially "locked" in a stable conformation. This glassy state further protects against molecular mobility and degradation.
- Excipients: Many freeze-dried formulations include excipients (like sugars such as trehalose or sucrose) which act as cryoprotectants and lyoprotectants. These excipients help maintain the peptide's structure during the freezing and drying process and contribute to the stability of the amorphous solid, reducing the likelihood of damage even if minor temperature fluctuations occur.
Conclusion:
- Allow to warm to room temperature before opening: For freeze-dried peptides stored in a freezer, it's generally recommended to allow the vial to warm to room temperature before opening. This prevents condensation of atmospheric moisture onto the cold powder, which could introduce unwanted water and compromise stability.
- Airtight Containers and Desiccants: Regardless of temperature, ensuring the freeze-dried powder is in a tightly sealed, airtight container, possibly with a desiccant, is critical to prevent moisture ingress.
- Retatrutide Specifics: Retatrutide is a peptide (a 39-amino acid peptide, a triple agonist targeting GLP-1, GIP, and glucagon receptors) and its stability, like other peptides, is highly dependent on storage conditions. As an investigational drug in clinical trials, precise handling and storage instructions are paramount to maintaining its integrity and efficacy.
The general consensus to freeze freeze-dried retatrutide is sound advice. While freeze-thaw cycles are a legitimate concern for peptide solutions, they are far less impactful on properly freeze-dried powders. The colder temperatures simply offer an additional layer of protection by further reducing residual moisture activity and slowing down any potential degradation pathways, thereby maximizing the stability and shelf life of the compound. The overarching principle is to minimize moisture exposure, and freezing is an excellent way to achieve this.
No stinging here, but added 3mL Hospira to their 60mg Tirz. We’ve only tested 2.5mg. Maybe 3mL prevented stinging?Did anyone ever get to the bottom of the stinging? I am on their Tirz and it stings moderately for an hour or two after pinning. I am a big boy and can cope fine but it does make you wonder...