Just an FYI for anyone interested in Cargilintide and has been thinking about fibrils that there is currently a group forming in STG's Discord Testing Server looking to have Jano run some tests on the formation of fibrils in reconsititued solutions. No decisions have been made about the test parameters at this point, but if you're interested in Cargi and been wondering about fibrils I thought some might be interested in joining. There are about 50 people in the group so far, so I'm thinking that testing won't be too expensive.
Cagri Fibrils Group Test
- Thread starter Grogu
- Start date
woundcarping
GLP-1 Specialist
I too, am interested in such things.
Raidenfat2fit
GLP-1 Apprentice
I'm interested. I'm currently awaiting for my order of reta and cagri to arrive. I've bought some standard bac water from my vendor but there's a lot of different opinions on whether or not bac water is enough and the possible risks are SCARY to say the least.
HereKittyKitty
GLP-1 Enthusiast
Holy seamonkeys! I never heard of fibrils until this moment. Is the testing for product from a specific vendor or the product in general? If general product, I have a vial to donate and am very interested for more information. Please.
Yeah, I hadn’t even heard about fibrils either [or the ph issue] until my first kit was well on its way to me. I haven’t done the deep dive into the research, so can’t say if fibrils are a real concern or smoke. So, the testing group should be interesting.
As far as donor vials, I think that the group in envisioning two vials, but the group is in the recruiting phase and testing parameters haven’t been determined. The people putting the group together appear to be very democratic at this point and I think the plan is to take polls about how the tests would be conducted.
I can DM some instructions on how to get to the testing server if you’re not familiar with Discord.
Thedooman445
GLP-1 Novice
🚫No Source Discussion🚫
Can I get a DM? I would love to participate 🙂
HereKittyKitty
GLP-1 Enthusiast
Sounds good. I am on Discord. Would you mind to please send me an invite via DM here?
@Thedooman445 and @MeedzMoar sent a DM with the Discord invite and how to access the group once in the server. Hopefully I did it correctly. I’m new to discord.
The StG testing server was nuked, but someone had posted a bunch of research, which I wish I had downloaded, but basically you use Thioflavin T, a chemical that turns fluorescent in the presence of fibrils.
Fluorescent Filter-Trap Assay for Amyloid Fibril Formation Kinetics in Complex Solutions - PMC
Amyloid fibrils are the most distinct components of the plaques associated with various neurodegenerative diseases. Kinetic studies of amyloid fibril formation shed light on the microscopic mechanisms that underlie this process as well as the ...
pmc.ncbi.nlm.nih.gov
👍🏻
Also something that might be helpful in considering fibrils, is that from the research I read before the nuke, I think that the consensus is that these fibrils are too large to break the Brain Blood Barrier (BBB) in normal healthy adults. Some small aggregates might break the barrier.
I personally don't want any extra fibrils floating around, even if too large to break the barrier. I haven't had time to research the mechanism (if one even exists) that fibrils in a SQ injection travel from fat into the bloodstream or if the fibrils stay localized in the fat. Unfortunately, I think that there is a lot unknown about fibrils.
Lyophilized
GLP-1 Apprentice
people with T1D insulin dependent suffer the same problem over all the years of SQ injections
So they are a good study subject to start. Insuline creates also fibrils at injection site
You will find a lot of scientific articles about this. Maybe even one with migration study..
I don´t believe that those fibril or aggregates migrate to other areas...but that´s my opinion...
So they are a good study subject to start. Insuline creates also fibrils at injection site
You will find a lot of scientific articles about this. Maybe even one with migration study..
I don´t believe that those fibril or aggregates migrate to other areas...but that´s my opinion...
Thanks so much for this! I'll look into this stream of research as it definitely sounds related to what the group on Discord was trying to look at prior to it being nuked. Thanks again!
So, the Cargilintide fibrils group had about 100 members and then the StG Discord Server got nuked and was never was restored.... What a bummer....
Tangentially related, not sure if anyone is interested, but I'm working with a couple of others on testing this cagri.
🧪 Group Test Recruiting
📦 AMO/BFF Cagrilintide C10
🗓️ Batch #107220 – 12/2/2025
Tangentially related, not sure if anyone is interested, but I'm working with a couple of others on testing this cagri.
🧪 Group Test Recruiting
📦 AMO/BFF Cagrilintide C10
🗓️ Batch #107220 – 12/2/2025
Last edited by a moderator:
CNCCurrency
GLP-1 Specialist
I thought this, Unlike native human amylin, which is highly prone to forming amyloid fibrils, cagrilintide is specifically designed to minimize this, allowing for better formulation stability.
I've also been thinking that even if fibrils form in the vial, I'm not sure if they can travel from the SQ location to the brain and cross the BBB.
philicibine
Recently Joined
🚫No Source Discussion🚫
Very interested to see the results of this. It might lay to rest some worries alot of people have.
Is there a group to join?
Yeah, it would be great to see the results. The good news was that the group had a HUGE number of folks interested in testing and sharing the cost of the tests, but the BAD news is StG's Discord Server was nuked and wasn't restored. So, there is no way to get back in touch with those 100+ folks.
Still looking to see if a new group reformed after the nuke, but it doesn't look like it.
petrelintide maybe the replacement as it is potent, stable, long-acting analogue of human amylin that can be formulated at about neutral pH. Studies show that there is no fibril formation. currently in phase 2 clinical studies with semi
HereKittyKitty
GLP-1 Enthusiast
I don't have this batch from this vendor but I will contribute to cost of testing. Can you connect me to the group?
retarequired
GLP-1 Apprentice
I know I'm late but if this is somehow still happening I'd like to contribute!
It got nuked a few months ago and I don't think it ever reorganized (unfortunately).
Exactly. My research shows this is mostly a non-issue. Fibrils don't migrate in the body. Amyloid plaques found in Alzheimer's patients are an example of fibrils. They don't cause problems anywhere else. If a fibril formed at the injection site, even if formed, the immune system would attack it right where it is. I'm not worried from what I've seen.
Eloralintide beats both of them. Significantly more weight loss after a year of use (~20% vs ~10%) and unlike both its specific to amylin 1/3 and not calcitonin. Also developped for low to no propensity to fibrils. Cant wait for it to be produced in china.
Raidenfat2fit
GLP-1 Apprentice
Damn so I wasted money on cagri for nothing, this is probably the drug I'm waiting on the most, stacking this with reta would basically be bariatric surgery in a jab, I'd never have to worry about being obese again 😊
lessthanhalf
Banned
I think the bigger advantage of eloralintide is the good weight loss with quite a lot less side effects than cagrilintide, which has pretty high rates of nausea and vomiting, at least at higher doses used in the studies like 2.4mg. But it is not available from china yet, so cagri is the only option for amylin agonists at the moment, except pramlintide which is for diabetes.
