Cagri finally (I think!)

[Captconundrum]

Now 2 days after my T6mg/5day and 1 day after Cagri 0.75mg third dose in the first week (1.1mg total week one out of the gate) finally I (think) I am feeling the cumulative effect of C + T suppression. Basically standard 3rd day T suppression but amped up, effectively mimicking my first ever couple of 2.5mg weeks but more intensive. Would say nausea rather than suppression. The oddity of this is I was such a strong responder to T and expected the same with the next peptide. I know it's amylin not GLP but still, body sensitivity (should be?) body sensitivity. It's the variance that is striking, how the same physiology that reacts to T immediately requires nearly a full dose of C to even get going. This may be turning into an amylin journal but I am really interested/curious if any scientific insights or practical experience why.

 

[nonyabizznez]

Pretty much same with me. Got to 1.25mg Cagri on top of my 5mg Tirz (took 5mg all the way to goal) and the fact I'm not getting the day 5/6 hangry issues keeps me taking Cagri. (No negative effects)

 

[peptideusername]

Now 2 days after my T6mg/5day and 1 day after Cagri 0.75mg third dose in the first week (1.1mg total week one out of the gate) finally I (think) I am feeling the cumulative effect of C + T suppression. Basically standard 3rd day T suppression but amped up, effectively mimicking my first ever couple of 2.5mg weeks but more intensive. Would say nausea rather than suppression. The oddity of this is I was such a strong responder to T and expected the same with the next peptide. I know it's amylin not GLP but still, body sensitivity (should be?) body sensitivity. It's the variance that is striking, how the same physiology that reacts to T immediately requires nearly a full dose of C to even get going. This may be turning into an amylin journal but I am really interested/curious if any scientific insights or practical experience why.

To add to your curiosity, the first time I pinned 250mcg of cagri, I couldn't eat for 48 hours.

 

[indolent]

@Captconundrum, it would be much better if you further commented on the same thread you initially created (https://glp1forum.com/threads/cagri-nothing.2893/), instead of creating a second thread on the same topic (https://glp1forum.com/threads/cagri-still-nothing-in-fact-the-opposite.2902/) and this, the third one.

That way, readers in the future can learn comprehensively from your progressive steps taken, and the results.

 

[Captconundrum]

@Captconundrum, it would be much better if you further commented on the same thread you initially created (https://glp1forum.com/threads/cagri-nothing.2893/), instead of creating a second thread on the same topic (https://glp1forum.com/threads/cagri-still-nothing-in-fact-the-opposite.2902/) and this, the third one.

That way, readers in the future can learn comprehensively from your progressive steps taken, and the results.

Yes that makes a lot of sense thank you!

 

[Captconundrum]

Cagri Day 10

I am appending a followup here in the same thread as @indolent suggested.

So finally 12+ hours after 0.8mg (!) there is a noticeable effect thats independent from Tirz and definitely different. The food aversion kicks in about 12 hours after pin and is definitely not nausea (the Tirz affect) but instead a lower grade aversion to food. However from previous doses I am expecting it to be pretty short-lived to be honest (and this before I have had time to get used to it), let's see next 7-10 days. At this rate I would end up at 2mg/week in multiple doses which is WAY more than I ever expected (I thought maybe 0.5-0.7mg).

I guess my observations on Cagri are several already. First, there is a WIDE sweet spot range, I am literally living proof. Second, if you are intent on using it (and some aren't) be prepared to start very low but go through the gears pretty rapidly if you 'need to.' I went from the ultra cautious 0.15mg to 1.6mg/week basically in 10 days. Third, sensitivity to amylin agents is TOTALLY independent of GLP1 sensitivity; I have responded well to Tirz and a lot less to Cagri.

Which of course begs the question why continue it? I am way off my original protocol - (which was a bit of extra Cagri to add suppression around my Tirz dosing), and never intended to become a 2 medication lab rat. Question I am asking myself, will stay on it for another couple of weeks then see if the extra stack is really worth it. Maybe to stay lower on Tirz overall I guess, that seems like the biggest positive in my mind. Also, if at some point at or around 1.5-2mg a week suppression lasts for longer than it has so far, then maybe that combo of benefits will be worth it. Jury definitely still out, and nowhere near a slam-dunk addition.

Finally, after reading more than I ever thought, I am being really careful with this stuff. Taking care to keep refrigerated, and planning to toss vials earlier than 28 days just to limit risk of degradation. I know it's been formulated to avoid fibrils and Novo chose it over dozens of other options, but I also have enough info that suggests Cagri is just a bit more fragile than GLPs, and last I checked I don't have another body.

The sema idea (instead of Cagri) is an interesting one. I'd resisted stacking GLPs simply to avoid screwing around with their effects too much. They were formulated each in a certain way for a reason, and I respect the effort that went into that research. But compared to spending $50-100 a week on Cagri, Sema does seem awfully tempting as an option. Or be a simpleton and just move up on Tirz and stop all this faffing around.

Not at all the journey I had expected, and thought helpful to share.

 

[nonyabizznez]

But compared to spending $50-100 a week on Cagri, Sema does seem awfully tempting as an option.

I am having a similar experience with Cagri all the way up until this sentence. Gray Cagri is currently around $2.30/mg (source PGB). More Tirz would be cheaper but doesn't have the Amylin component.

 

[Captconundrum]

I am having a similar experience with Cagri all the way up until this sentence. Gray Cagri is currently around $2.30/mg (source PGB). More Tirz would be cheaper but doesn't have the Amylin component.

You are right thats me moaning about single vial price but as you say even breaking open my kit of Cagri it is still a lot more per mg than adding Tirz. Needs to over perform to justify the $ even vastly reduced. V surprised you are having a similar experience, maybe we are spoiled by the GLPs.

 

[Super Trips]

Cagri Day 10

I am appending a followup here in the same thread as @indolent suggested.

So finally 12+ hours after 0.8mg (!) there is a noticeable effect thats independent from Tirz and definitely different. The food aversion kicks in about 12 hours after pin and is definitely not nausea (the Tirz affect) but instead a lower grade aversion to food. However from previous doses I am expecting it to be pretty short-lived to be honest (and this before I have had time to get used to it), let's see next 7-10 days. At this rate I would end up at 2mg/week in multiple doses which is WAY more than I ever expected (I thought maybe 0.5-0.7mg).

I guess my observations on Cagri are several already. First, there is a WIDE sweet spot range, I am literally living proof. Second, if you are intent on using it (and some aren't) be prepared to start very low but go through the gears pretty rapidly if you 'need to.' I went from the ultra cautious 0.15mg to 1.6mg/week basically in 10 days. Third, sensitivity to amylin agents is TOTALLY independent of GLP1 sensitivity; I have responded well to Tirz and a lot less to Cagri.

Which of course begs the question why continue it? I am way off my original protocol - (which was a bit of extra Cagri to add suppression around my Tirz dosing), and never intended to become a 2 medication lab rat. Question I am asking myself, will stay on it for another couple of weeks then see if the extra stack is really worth it. Maybe to stay lower on Tirz overall I guess, that seems like the biggest positive in my mind. Also, if at some point at or around 1.5-2mg a week suppression lasts for longer than it has so far, then maybe that combo of benefits will be worth it. Jury definitely still out, and nowhere near a slam-dunk addition.

Finally, after reading more than I ever thought, I am being really careful with this stuff. Taking care to keep refrigerated, and planning to toss vials earlier than 28 days just to limit risk of degradation. I know it's been formulated to avoid fibrils and Novo chose it over dozens of other options, but I also have enough info that suggests Cagri is just a bit more fragile than GLPs, and last I checked I don't have another body.

The sema idea (instead of Cagri) is an interesting one. I'd resisted stacking GLPs simply to avoid screwing around with their effects too much. They were formulated each in a certain way for a reason, and I respect the effort that went into that research. But compared to spending $50-100 a week on Cagri, Sema does seem awfully tempting as an option. Or be a simpleton and just move up on Tirz and stop all this faffing around.

Not at all the journey I had expected, and thought helpful to share.

I feel like cagri is a good short burner like 2 weeks to a month then it loses the effects or "feels" as some put it. i went as high as 3mg every 3-4 days on a stack and burned through it quickly when chasing that 1st or 2nd week push

 

[chmuse]

I am having a similar experience with Cagri all the way up until this sentence. Gray Cagri is currently around $2.30/mg (source PGB). More Tirz would be cheaper but doesn't have the Amylin component.

Crypto-doser still on .04 dose every Saturday and Sunday (doing .08 on one day makes me ill, two days in a row and I'm okay.) Wild how we're all hit so differently!

 

[nonyabizznez]

Crypto-doser still on .04 dose every Saturday and Sunday (doing .08 on one day makes me ill, two days in a row and I'm okay.) Wild how we're all hit so differently!

But you're dosing a bird right? It's all about proportion.

 

[Captconundrum]

Cagri Day 20

Encapsulating my observations now that I have settled into a kind of 'steady state,' which for me is T 7.5-8.5mg / 5 days, + adding C 1mg / 5 days 2-3 days after T.

What is the point of this? First, maintenance looms in 2-3 months and I want to 'stay low' on T to make adjusting to maintenance easier/less disruptive (not sure my protocol for that yet, but some version of reducing dosage/stretching out days). Also the reference studies show weight loss at T 10mg and 15mg basically asymptotes to nearly the same, so we don't seem to get more bang out of ⅓ more dosage and why pour more in if it isn't giving me more value? The added C is really to push through the next 2-3 months solidly.

Why 2-3 days after T? Well even at 5 day intervals, the day of the next T shot and a day or so after that the suppression moderates. I am not going for total aversion here, just trying to smooth the general suppression profile day in day out (tried split T doses for this, worked less well as the single shot spike seemed to have greater effect).

My experience finally at 1mg C is day 1 shivers (big time) and no suppression, but now finally the next day it definitely works. I mean that infamous aversion feeling really kicks in and I can feel it as I write this (morning day after C shot). This for me is short-lived but I don't care, I am only looking for a bit of extra suppression until a day or so after T shot day (tomorrow). So the bridging effect works fine. My expectations of C have really moderated, I thought at 0.25mg it would whack me hard, but definitely hasn't, but I also don't need to accelerate to 2mg+.

Finally, I am using each vial of C for 3 weeks then tossing. The blessings of gray is I can do that without feeling the $ pinch. Why? An abundance of caution re stability (no matter what anyone says C is inherently more 'fragile' than the GLPs), I get enough use out of it and anyway I don't plan to roll through more than 1 kit max at this rate so the $ loss is pretty minimal.

Now after all this trial and error, would I recommend this stack? Yes, finally I would. C does its job to a certain extent for me, I like the ability to flex out of it when hitting maintenance, and my expectations of it are moderate and it delivers. I can definitely see why it's not a weight loss world beater on its own, but I don't care.

Would I go higher on C? No, no need to really but I am sure it would be fine within reason (I figure 1mg/5 days = 1.4mg/7 days which is the low end of standard dosing so not a big deal). Could easily go to 1.5mg C /5 days with impunity IMO.

Here is how I might describe all this. Tirz is 'strategic' - the anchor of this whole journey (never shifted to Reta because I don't need to - just trying to lose some pounds here guys, not optimize for next-gen GLPs). Cagri is 'tactical' - a focused add-on for a while. All possible because of the unimaginably great gift of being able to go gray with confidence.

And on that confidence point, finally my only source has been Nexaph. Ph checks out, they are all over sterility from everything I have seen, and nothing I have bought from them has been in any way 'less than.' Why would I be adventurous re source? Gray is adventure enough! Esp for Cagri, land on a source you trust and do not move.

Hope some of the above is helpful in some way to someone sometime....

 

[dogmom]

Is it helping you lose weight?

 

[Captconundrum]

Is it helping you lose weight?

Well I’d say it’s helping keep weight loss steady even as I plateau dosage and get nearer to goal. So what might have otherwise tapered off hasn’t. This is what I wanted and if cagri is helping ‘insure’ that that has value to me!