Can research-grade GHK-CU be used to make a topical serum?

Why would anyone want to pay 10x more for lypholized ghk to make a topical application when they can buy it unlypholized for a fraction of the cost.

If it’s not going to be injected why pay to have it prepared as such
 
CNCCurrency said:
Still say hog wash:
Lyophilized peptide fillers, such as mannitol and trehalose, are inert substances added to peptides before freeze-drying to protect their structure and stability

Trehalose is a natural, stable disaccharide sugar (
derived from sources like mushrooms and tapioca, used widely as a stabilizer, sweetener, and hydrating agent. It is roughly 45-55% as sweet as sucrose, protects against moisture loss in food, and stabilizes protein-based drug formulations. It is also used in eye drops for dry eye and holds promise as a neuroprotective agent
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The issue isn't that you're adding trehalose to the skincare formula or the fact that the ingredient is lyophilized. In fact trehalose is often used as a humectant in formulations, more so in the East than the West. It's a less superior humectant than hyaluronic acid, and more expensive than glycerin without really adding additional benefits, so it's often just there as label appeal.

In professional formulations, everything must and needs to be exact as every ingredient has a compatibility range, and there are different regulatory thresholds for each ingredient (if it is regulated) according to what kind of product you're formulating. This will also vary according to the standards of the local regulation. So you need to be able to break down every individual ingredient in exact percentages and a real formulator or a contract manufacturer simply would not use the injectable version as it adds a lot of unwanted variables that could potentially be problematic or just annoying to deal with.

ETA.. I forgot to mention the most important factor in manufacturing: cost. The topical/raw ingredient is considerably cheaper than the injectable lyophilized version. You can get an entire gram of the raw ingredient for a few dollars in bulk.. $10 if you are buying single vials from resellers. One vial of an injectable GHK-Cu only contains 50mg or 100mg, which obviously ends up being far less economic.
 
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GortBong said:
Some research I did so far said not to use research grade ghk-cu for topical use, and that only cosmetic grade should be used topically.

Thoughts?

Also, any suggestions for a serum recipe to apply to the scalp for thicker hair? I would think the facial serum recipes would be too thick for the scalp.

Thanks for any guidance!!
Click to expand...
YEP.... When the burn juice is to intense but one has a end of the world amount of GHK-cu you make lemonade with them burn lemons. Not saying that is the most cost efferent way to rub some ghk-cu on your face but you work with what you got.... lol..
 

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wildweasel said:
Why would anyone want to pay 10x more for lypholized ghk to make a topical application when they can buy it unlypholized for a fraction of the cost.

If it’s not going to be injected why pay to have it prepared as such
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Yes exactly, and not only that, but there is actual danger in adding additional ingredients to a premade formula without adding additional preservatives. When you use the injectable version, which includes other materials including fillers, you are adding more variables which increases the chances of contamination. Plus the fillers could change the viscosity of the product, making it break completely or turn gloopy. If the injectable ingredient has been buffered on top of being freeze-dried, you have even more problems to deal with.
 
miameow said:
The issue isn't that you're adding trehalose to the skincare formula or the fact that the ingredient is lyophilized. In fact trehalose is often used as a humectant in formulations, more so in the East than the West. It's a less superior humectant than hyaluronic acid, and more expensive than glycerin without really adding additional benefits, so it's often just there as label appeal.

In professional formulations, everything must and needs to be exact as every ingredient has a compatibility range, and there are different regulatory thresholds for each ingredient (if it is regulated) according to what kind of product you're formulating. This will also vary according to the standards of the local regulation. So you need to be able to break down every individual ingredient in exact percentages and a real formulator or a contract manufacturer simply would not use the injectable version as it adds a lot of unwanted variables that could potentially be problematic or just annoying to deal with.

ETA.. I forgot to mention the most important factor in manufacturing: cost. The topical/raw ingredient is considerably cheaper than the injectable lyophilized version. You can get an entire gram of the raw ingredient for a few dollars in bulk.. $10 if you are buying single vials from resellers. One vial of an injectable GHK-Cu only contains 50mg or 100mg, which obviously ends up being far less economic.
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I also don't know how a formula can meet exacting additive percentages when using other than a cosmetic grade product. Available formulas assume cosmetic grade ingredients.

In skin care formulating, percentages matter.
 
CandyCap said:
I prefer to not trust my face (or in this case hair) with AI, but thanks.
They make cosmetic versions for a reason, which are readily available. Fillers can cause emulsion to break as well. I dont want that crap on my face.
I know of no professional formulator (I follow many) that would recommend using lyophilized as opposed to cosmetic. Too many variables to cause problems.
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Ma’am. The cosmetic versions are also lyophilized. I’ve been using them for almost 2 years.
 
YoYoFat said:
Ma’am. The cosmetic versions are also lyophilized. I’ve been using them for almost 2 years.
Click to expand...
The reference seems, pretty clearly, not to the format per se but to differentiate between research grade and cosmetic grade.
 
Can anyone pm me a link for research grade Ahk cu raw , my partner is on and on at me and Binh is sold out and Alice has doubled the price on hers and am not trusting she actually has it in stock looking at the poor reviews lately .
 
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