Changing my stack from Tirz + Reta to…

[cloratheshadow]

Considering switching my Tirz out for Sema. So far Reta has been really good and I’m currently at 8.5 mg Tirz and 4mg Reta. I’m kind of wanting to focus on Reta and lowering Tirz. But it had me thinking…

If Sema has more GLP-1 than Tirz and Reta
And Reta has more GIP than Tirz

Wouldn’t it be more cost effective to just switch my Tirz for Reta? I’m already getting everything with Reta, so adding a small bit of Sema to it for added satiety sounds easier to me. Sema is so cheap, kits are like $50.

Is there any reason not to?

 

[cheaperseeker]

Sema side effects are strong. I had to keep ginger beer in the house to deal with the nausea, even after I had been on it for 9 months

 

[cloratheshadow]

Sema side effects are strong. I had to keep ginger beer in the house to deal with the nausea, even after I had been on it for 9 months

I’ve kind of always dealt with nausea and I don’t really mind it (I struggle with vertigo)

What about microdosing?

 

[cheaperseeker]

I’ve kind of always dealt with nausea and I don’t really mind it (I struggle with vertigo)

What about microdosing?

Diarrhea, stomach cramps, fatigue, and sulfur burps were also a problem. Ugh sulfur burps were terrible.

You could always try it out and see how it affects you.

 

[bada bing]

Supposedly the GIP agonism in Tirz has the effect of moderating it's unwanted GLP1 side effects, which is an explanation of why it is better tolerated than Sema. The same GIP agonism is true for Reta. Hypothetically mixing Sema with Reta could have better tolerability than Sema alone while giving a more narrowly targeted boost in GLP1 effects..

It certainly is worth a slow careful try. I have a 5mg Sema kit I bought for just that use, if the need ever arises. Sema is cheap and stores very well in the freezer. There may come a time when it's obsolete and hard to source, so I consider it a cheap contingency investment.

 

[AllCourtTENNIS]

I started on tirz, plateaued for about 2 months at 12.5mg weekly, then started stacking with reta. I'm down to lowish dose tirz and 10mg reta. I'm losing but slowly. Others have had far more numerical success on this stack, but omg I feel so good compared to a year ago.

I've avoided sema because everyone I know irl who tried it had horrible GI side effects.

Edit: lol I forgot my signature shows my stack

 

[Flash-BCR]

Supposedly the GIP agonism in Tirz has the effect of moderating it's unwanted GLP1 side effects, which is an explanation of why it is better tolerated than Sema. The same GIP agonism is true for Reta. Hypothetically mixing Sema with Reta could have better tolerability than Sema alone while giving a more narrowly targeted boost in GLP1 effects..

It certainly is worth a slow careful try. I have a 5mg Sema kit I bought for just that use, if the need ever arises. Sema is cheap and stores very well in the freezer. There may come a time when it's obsolete and hard to source, so I consider it a cheap contingency investment.

I have sema also for the same reason...and am not sure if I will ever use it. It was $45 a kit for 5mg...

 

[Panderas785]

Diarrhea, stomach cramps, fatigue, and sulfur burps were also a problem. Ugh sulfur burps were terrible.

You could always try it out and see how it affects you.

Even after sema for almost six months. Would still get the random burps and runs at times. Went about six weeks no sides then bam, surprise ! Now I’m just split dosing Reta. I feel like I get no sides.