Hi friends. I am happy to share the results of a deep dive I did on the topic of LEAN body mass (versus TOTAL body mass, which includes lean, fat, and a small amount of "other").
I was concerned about this topic after listening to a podcast with Dr Attia, where he showed data that his patients on glp-1 agonists where losing more LEAN body mass than FAT mass, which would be bad. We want to lose fat... and spare the muscles. His evidence for this data was DEXA (whole body imaging) scans, which can be inaccurate when differences in hydration levels occur. I wanted to see if he was correct, based on other, more rigorous studies (his wasn't a study - it was an observation of his patients, many of whom tend to be health enthusiasts).
So here are some studies I found, from PubMed (NIH). I am not sure how long posts can go in this forum, so I will post studies in the comments. Pay attention to which glp-1 the study covers, many are Tirz (my interest area) but some are Sema.
Lastly these are the notes I personally took. I might have interpreted incorrectly. I am not a medical professional, I am just a mom. Please check with your doctor if you have questions on this!
I was concerned about this topic after listening to a podcast with Dr Attia, where he showed data that his patients on glp-1 agonists where losing more LEAN body mass than FAT mass, which would be bad. We want to lose fat... and spare the muscles. His evidence for this data was DEXA (whole body imaging) scans, which can be inaccurate when differences in hydration levels occur. I wanted to see if he was correct, based on other, more rigorous studies (his wasn't a study - it was an observation of his patients, many of whom tend to be health enthusiasts).
So here are some studies I found, from PubMed (NIH). I am not sure how long posts can go in this forum, so I will post studies in the comments. Pay attention to which glp-1 the study covers, many are Tirz (my interest area) but some are Sema.
Lastly these are the notes I personally took. I might have interpreted incorrectly. I am not a medical professional, I am just a mom. Please check with your doctor if you have questions on this!