Crohn's and Tirz

I don't have Crohn's but know several people who have colitis, including a friend who was on sema and had to do a few months on prednisone to get a flareup under control. Their doctor told them to stop taking sema for the duration of the flareup because there could be an interaction between the two drugs, and that sema may be ineffective while on it. I imagine, without even going into what happens with blood sugar, any weight loss would be masked by the amount of water retention people have on pred.

(and before anyone asks why I'm discussing these things with friends lol, they know i'm on a glp1, and they also know my mom and partner (and tbh my dog too) have colitis and sometimes have to go on pred so i know a bit about it)
 
My wife has ulcerative colitis and tirz has helped her tremendously. She used to run to the bathroom 10+ times a day, but tirz has slowed all of that down - less bathroom trips and less urgency while also dropping from 220lbs to 160. It's been amazing for her.
i have a really close friend who has UC and i've been confiding in her about my tirz journey along with the jump to gray. she's curious about it and i think would like to try but is concerned that it would do the opposite of help and actually make her UC flare ups even worse.

what convinced your wife to eventually make the plunge if you don't mind me asking? i want to help her gently to make the plunge with me, at least in the beginning to see if it's worthwhile. i haven't been able to find any "normie proof" data online to send her way to help convince her.
 
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