Day 3 of Selank and blown away

timj382 said:
That's amazing. Thanks for sharing your experience.

Now I'm curious what you do that you have patients.
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Bonus info: it also helps me with my lag of 'executive function'. it's just easier for me to get the shit done at home fx.
I'm a GP, a medical doctor in Denmark. My everyday worklife is highly stressful and eventful, but with the two peptides, I come home and have maybe 15 % energy left to do stuff. Before these I was usually all wiped out.
It's become worse because I've gone into perimenopause.
Yes I should see a psychiatry about it. No, I don't really want to, because I don't like stimulants for myself.
 
miss-sanne said:
Bonus info: it also helps me with my lag of 'executive function'. it's just easier for me to get the shit done at home fx.
I'm a GP, a medical doctor in Denmark. My everyday worklife is highly stressful and eventful, but with the two peptides, I come home and have maybe 15 % energy left to do stuff. Before these I was usually all wiped out.
It's become worse because I've gone into perimenopause.
Yes I should see a psychiatry about it. No, I don't really want to, because I don't like stimulants for myself.
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It's encouraging to see a GP here.

Peptide sounds great.

My primary (our US word for it) prescribes Modafinil for me and it's been a game changer. Sounds like similar results. Maybe a bit more… turbo driven. Haha.
 
timj382 said:
It's encouraging to see a GP here.

Peptide sounds great.

My primary (our US word for it) prescribes Modafinil for me and it's been a game changer. Sounds like similar results. Maybe a bit more… turbo driven. Haha.
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I did Modafinil daily, but after 7-10 days, I become depressed and anhedone.
So I only use it sometimes.
I would MAYBE want to try Atomoxetin, but right now I'm happy with peps.
 
This is so interesting and thank you for sharing the experience with Selank. Have Selank and Semax in line for research and wondering what's the route to go, Intranasal vs IM for OCD / Anxiety, overthinking
 
jw717us said:
RS is on day three of research and in our experience this is gaming changing for my subject. They didn’t know they needed it. Apparently they have been in anxiety denial their entire life. A recent major life impact sent them into a spiral and we decided to try it just to see if it would help.

Three days ago we reconstituted 10mg with 10ml sterile saline in a 10ml nasal spray bottle that disburses .1ml per spray.At lunch time RS sprayed in each nostril and within the hour saw a notable shift in mindset. Constant background concerns faded away to a feeling of control and calm. RS will be trying 4 weeks on, 2 off for several cycles.

The past 3 days suggests that if someone has the right brain chemistry, it will have an immediate impact for. After the first day, RS learned they had been conning myself about things in my life. Apparently RS was a bit of an anxiety ridden mess that lied to myself that I was just always ready for the worst case. It was viewed as a good thing rather than a key sign of high anxiety. RS is high functioning and successful so they couldn’t possibly have anxiety, right??? Clearly wrong..

We just started the Peptide journey due to weight.. RS went from GLP1 via local through support via telemedicine. As we read we ended up going grey. After looking over a list of peptides we noticed comments about Selank for anxiety. We never….never…. bought into anxiety, at least in RS’s personal case. They brushed off a lot of signs and some friends suggesting it may be an issue. As we read more about Selank we realized that the people it helped in the Russian studies exhibited very similar symptoms to RS..

The more we read the more we realized RS was an absolute stereotype for anxiety. Every symptom showed could be traced back to childhood. That childhood experience primed RS for extreme anxiety and eventually cardiac issues in midlife despite being otherwise very healthy….weight aside and GLP1 helped dramatically there.

We decided to give it a shot….well a spray as it were. Within hours we noticed a fundamental difference to how RS was reacting. This is already too long so I’ll spare the details. I can only suggest if it has no, or minimal, effect on you then perhaps you are already wired normally and Selank isn’t the path for you.

I am genuinely optimistic for the remodeling effect exhibited in studies at this point, but the peace of mind it has already delivered is unbelievable. We are now looking at the possibility of adding Semax in the future.
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Very good to hear! I’m trying to tell myself that I can tolerate nasal selank.. but my mom used to use some otc nasal spray on me as a child that smelled like male cat pee.. which left me very averse to ANYTHING nasal… so I’m having to work myself up to trying it..
 
FlowerFairy said:
Very good to hear! I’m trying to tell myself that I can tolerate nasal selank.. but my mom used to use some otc nasal spray on me as a child that smelled like male cat pee.. which left me very averse to ANYTHING nasal… so I’m having to work myself up to trying it..
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I don't think it has an odor, and I'm pretty sensitive to smells.
 
FlowerFairy said:
Very good to hear! I’m trying to tell myself that I can tolerate nasal selank.. but my mom used to use some otc nasal spray on me as a child that smelled like male cat pee.. which left me very averse to ANYTHING nasal… so I’m having to work myself up to trying it..
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For my RS and RS's spouse there are no discernible odors or aftertastes. RS isn't sensitive but spouse is. Flonase for spouse was a disaster. For these it's no different than a saline spray.
 
reyqaz said:
This is so interesting and thank you for sharing the experience with Selank. Have Selank and Semax in line for research and wondering what's the route to go, Intranasal vs IM for OCD / Anxiety, overthinking
Click to expand...
If your goal is immediate effect and to be able dose flexibly, I think IN is the way to go. Bioavailability is higher (~90%) because IN bypasses the first-pass hepatic metabolism, which means your liver isn't breaking it down before it reaches your brain, so you can use less, and you're also placing the peptide more efficiently, closer to point of impact which is your brain and pituitary. All of this means the effects should be more acute. Also, I hope that was a typo and you mean Subq and not IM. Very, very few peptides are administered via IM.
 
Chili777 said:
If your goal is immediate effect and to be able dose flexibly, I think IN is the way to go. Bioavailability is higher (~90%) because IN bypasses the first-pass hepatic metabolism, which means your liver isn't breaking it down before it reaches your brain, so you can use less, and you're also placing the peptide more efficiently, closer to point of impact which is your brain and pituitary. All of this means the effects should be more acute. Also, I hope that was a typo and you mean Subq and not IM. Very, very few peptides are administered via IM.
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Yep, I did mean subq, thanks for the info, much appreciated, any guide on creating this Intranasal saline spray? Thanks again.
 
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reyqaz said:
Yep, I did mean subq, thanks for the info, much appreciated, any guide on creating this Intranasal saline spray? Thanks again.
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Yes, there are a few posts here that explain the process.
 
jw717us said:
RS is on day three of research and in our experience this is gaming changing for my subject. They didn’t know they needed it. Apparently they have been in anxiety denial their entire life. A recent major life impact sent them into a spiral and we decided to try it just to see if it would help.

Three days ago we reconstituted 10mg with 10ml sterile saline in a 10ml nasal spray bottle that disburses .1ml per spray.At lunch time RS sprayed in each nostril and within the hour saw a notable shift in mindset. Constant background concerns faded away to a feeling of control and calm. RS will be trying 4 weeks on, 2 off for several cycles.

The past 3 days suggests that if someone has the right brain chemistry, it will have an immediate impact for. After the first day, RS learned they had been conning myself about things in my life. Apparently RS was a bit of an anxiety ridden mess that lied to myself that I was just always ready for the worst case. It was viewed as a good thing rather than a key sign of high anxiety. RS is high functioning and successful so they couldn’t possibly have anxiety, right??? Clearly wrong..

We just started the Peptide journey due to weight.. RS went from GLP1 via local through support via telemedicine. As we read we ended up going grey. After looking over a list of peptides we noticed comments about Selank for anxiety. We never….never…. bought into anxiety, at least in RS’s personal case. They brushed off a lot of signs and some friends suggesting it may be an issue. As we read more about Selank we realized that the people it helped in the Russian studies exhibited very similar symptoms to RS..

The more we read the more we realized RS was an absolute stereotype for anxiety. Every symptom showed could be traced back to childhood. That childhood experience primed RS for extreme anxiety and eventually cardiac issues in midlife despite being otherwise very healthy….weight aside and GLP1 helped dramatically there.

We decided to give it a shot….well a spray as it were. Within hours we noticed a fundamental difference to how RS was reacting. This is already too long so I’ll spare the details. I can only suggest if it has no, or minimal, effect on you then perhaps you are already wired normally and Selank isn’t the path for you.

I am genuinely optimistic for the remodeling effect exhibited in studies at this point, but the peace of mind it has already delivered is unbelievable. We are now looking at the possibility of adding Semax in the future.
Click to expand...
Awesome report, thank you for sharing this- 🙏
 
Selank calms me down... but it basically completely kills any joy of life as well... like I feel completely emotionless... zero motiviation... and this is on a small dose... if I take a regular dose I feel completely dead emotionally... and a weird kinda deperession... gave it up... shit was not good for me
 
As someone who is pretty deep into nootropics, I am thoroughly surprised selank and semax have made the comeback they have. I think they are mediocre as far as the realm of nootropics goes overall. I'm not saying they don't work - but if they work well for you rest assured there is plenty more out there!
 
asdfasdf said:
As someone who is pretty deep into nootropics, I am thoroughly surprised selank and semax have made the comeback they have. I think they are mediocre as far as the realm of nootropics goes overall. I'm not saying they don't work - but if they work well for you rest assured there is plenty more out there!
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Which ones do you like? I haven't tried semax on its own, just in a blend with selank, and selank on its own. I was not impressed by any of it
 
Nabster said:
Which ones do you like? I haven't tried semax on its own, just in a blend with selank, and selank on its own. I was not impressed by any of it
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I am a full time SWE.
If I had to rank my nootropics by most effective at the number one spot bar none is sub-hallucinogenic doses of (not microdosing) pharmahuasca (5-meo-dmt administered alongside a MAOI). But the risks, difficulties in procuring for most, and lifestyle/dietary changes due to the MAOI make this very difficult to endorse for another person.
Second is creatine/high dose EPA fishoil. I personally maintain a steady intake of 6G+ total Omega3 in liquid form daily. As for creatine (I take liposomal form for extended release), two times per day with proper hydration. I know this sounds pedantic but seriously if you aren't doing this, or have room to grow, then up this before more noots.
Tropisetron, Mag-L-Threonate, BPN-14770, Clomipramine, JNJ-42165279, Tak-653, all honorable mentions.
 
asdfasdf said:
I am a full time SWE.
If I had to rank my nootropics by most effective at the number one spot bar none is sub-hallucinogenic doses of (not microdosing) pharmahuasca (5-meo-dmt administered alongside a MAOI). But the risks, difficulties in procuring for most, and lifestyle/dietary changes due to the MAOI make this very difficult to endorse for another person.
Second is creatine/high dose EPA fishoil. I personally maintain a steady intake of 6G+ total Omega3 in liquid form daily. As for creatine (I take liposomal form for extended release), two times per day with proper hydration. I know this sounds pedantic but seriously if you aren't doing this, or have room to grow, then up this before more noots.
Tropisetron, Mag-L-Threonate, BPN-14770, Clomipramine, JNJ-42165279, Tak-653, all honorable mentions.
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Is this to replace Semax for ADHD? I don't see that happening for anyone I know who isn't already medicated 🤣.
 
mtomm said:
Is this to replace Semax for ADHD? I don't see that happening for anyone I know who isn't already medicated 🤣.
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Read what I am replying to.... I was asked what nootropics I enjoy and I responded accordingly.
 
asdfasdf said:
Read what I am replying to.... I was asked what nootropics I enjoy and I responded accordingly.
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Yes, I realized what it was a response to and just kind of thought it was funny because there was no way a regime like that would be adhered to by my ADHD family. I'm sure many people find your response helpful.
 
mtomm said:
Yes, I realized what it was a response to and just kind of thought it was funny because there was no way a regime like that would be adhered to by my ADHD family. I'm sure many people find your response helpful.
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ah I misunderstood - didn't mean to come off anal a bit too 'dialed in' perhaps.
 
asdfasdf said:
As someone who is pretty deep into nootropics, I am thoroughly surprised selank and semax have made the comeback they have. I think they are mediocre as far as the realm of nootropics goes overall. I'm not saying they don't work - but if they work well for you rest assured there is plenty more out there!
Click to expand...
Just to preemptively clarify, I am asking the following with genuine curiosity and no negative connotation:

Your post here seemed to me like you are saying Semax and Selank were mediocre noots, and that you were aware of others that would be more beneficial (presumably to assist with a similar set of benefits that Semax/Selank provide).

However your next post, (I know it was in answer to what your favorite noots were) I didn’t quite see the direct correlation to Semax/Selank- and perhaps it wasn’t meant to be.

With all that said, do you have any nootropic suggestions to directly supersede Semax/Selank in efficacy, in your experience?
 
writing to second the question, if not to the original answerer.
 
i should mention that semax makes me foggy but selank is perfect for reducing "noise," so to speak, and would welcome more compounds in a similar vein without too much additional stimulation. dmt and maois, which asdf suggested, are certainly not similar!
 
nnnnnaaaaa said:
i should mention that semax makes me foggy but selank is perfect for reducing "noise," so to speak, and would welcome more compounds in a similar vein without too much additional stimulation. dmt and maois, which asdf suggested, are certainly not similar!
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Yeah that was a wild ride of a reply lol. We went from DMT to Creatine/ Fish Oil haha.
 
dirtyharry said:
Yeah that was a wild ride of a reply lol. We went from DMT to Creatine/ Fish Oil haha.
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DMT at sub hallucinogenic doses when taken orally is a modulator of the 5-ht2a site. This is incredibly pro cognitive and the co-administered MAO-I is to help prevent the breakdown of the molecule in your system. I couldn't work on high dose DMT. That said, since I see its maybe a rubicon too far for most let me say this.
A great alternative to Selank is NSI-189 taken with Magnesium L-Threonate.
There are some interesting compounds in development for fragile x syndrome right now the most interesting of which is zatomilast which seems to greatly increase dendritic density. There are no RCTs in otherwise healthy humans so I am hesitant to endorse but caregiver ratings and coding score tests.

If you wanna get really wild you can always go for nightly vTNS.

Personally also using a far bit of tropisteron these days.
 
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