Dermorphin for pain?

hardtaildawn said:
Has anyone ever used Dermorphin, a peptide that I’ve recently read is very good for chronic pain?
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It made me itchy for like three hours. Everywhere! I tried it subcutaneous. Don’t know about IM or otherwise. I still have 9 vials of it that I will never use. lol
 
There was pain relief, but the itching was unbearable for me. I did like that it didn’t have that euphoric sensation that you get with morphine, which is probably good for people prone to that type of addiction? I took a very small dose of .5 mg. I’m 6’ 1” and weighed about 215 at the time. I’m confident that stuff could put me on my ass.
 
Thank you for replying. I’ve been researching it for about a month. Yours is the most detailed side effect that I’ve heard, not one which I would enjoy. I’m sure. I’m gonna keep researching. I have to be honest. It’s really attractive thinking that there might be a solution to this back pain
 
hardtaildawn said:
Thank you for replying. I’ve been researching it for about a month. Yours is the most detailed side effect that I’ve heard, not one which I would enjoy. I’m sure. I’m gonna keep researching. I have to be honest. It’s really attractive thinking that there might be a solution to this back pain
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I just buy muscle relaxers (Tizanidine) from India. Keeps risk for addiction low and they are super cheap. You can get a year supply for about $75.
 
hardtaildawn said:
Thank you for replying. I’ve been researching it for about a month. Yours is the most detailed side effect that I’ve heard, not one which I would enjoy. I’m sure. I’m gonna keep researching. I have to be honest. It’s really attractive thinking that there might be a solution to this back pain
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Could you please say more, as my life is pain. Thanks.
 
Dang no, too scared to try given how strong it is. Even with testing, I still don't trust vendors enough with my life, a decimal error is so easily made

With Tirz I'm gonna be sick but I won't die at least
 
Die??? Not trying to do that. thats a good point. It would definitely have to be privately tested. I haven’t decided to move forward with it. There’s not a lot of research on it that I couldn’t find however, it’s really attractive. Gonna keep looking seeing what I can hopefully get some more people who have used and maybe are still using it and get their feedback.
 
hardtaildawn said:
Die??? Not trying to do that. thats a good point. It would definitely have to be privately tested. I haven’t decided to move forward with it. There’s not a lot of research on it that I couldn’t find however, it’s really attractive. Gonna keep looking seeing what I can hopefully get some more people who have used and maybe are still using it and get their feedback.
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I would be interested in the intellectual discussion of it and knowing ever there is to know. BUT. I doubt very seriously without understanding every ingredient, excipient….that I would ever inject it.
 
AndyPanda said:
I just buy muscle relaxers (Tizanidine) from India. Keeps risk for addiction low and they are super cheap. You can get a year supply for about $75.
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Would you be able to point me in the direction of where you order from? I found a couple potential sources, but a referral would be really helpful.
 
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Got some for my wife's chronic back pain. I decided to be the guinea pig and tried it first. 60mcg. Made me a bit light headed for 30 minutes. That's about it. She said the same. 70mcg the next night. We're still here. lol.
I store it in a refrigerator in our garage, completely separate from all other peptides. When I want a dose, I take my alcohol swab and syringe out there to get it. No chance of mixing them up and making a mistake. That would be tragic.
 
ktg123 said:
I store it in a refrigerator in our garage, completely separate from all other peptides. When I want a dose, I take my alcohol swab and syringe out there to get it. No chance of mixing them up and making a mistake. That would be tragic.
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Great advice. And along with having someone with you, it also helps to have Narcan:

Google Gemini said:
Even with opioid peptides like Dermorphin, Narcan (naloxone) will still be effective in reversing an overdose.
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Pharmacological data on dermorphins, a new class of potent opioid peptides from amphibian skin - PMC

1 Dermorphin and Hyp6-dermorphin are the first representatives of a new class of potent opioid peptides occurring in amphibian skin. They present the unique feature of having a D-Ala residue incorporated in the peptide molecule. 2 Dermorphin ...
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
Naloxone was a powerful antagonist to dermorphin
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ktg123 said:
Got some for my wife's chronic back pain. I decided to be the guinea pig and tried it first. 60mcg. Made me a bit light headed for 30 minutes. That's about it. She said the same. 70mcg the next night. We're still here. lol.
I store it in a refrigerator in our garage, completely separate from all other peptides. When I want a dose, I take my alcohol swab and syringe out there to get it. No chance of mixing them up and making a mistake. That would be tragic.
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Any pain relief or just the light headedness?
 
scarywood75 said:
Dang no, too scared to try given how strong it is. Even with testing, I still don't trust vendors enough with my life, a decimal error is so easily made

With Tirz I'm gonna be sick but I won't die at least
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Muscle relaxers, yes. Pain medication, no. Last time I really threw out my back and could barely get in and out of a chair or take a few steps I turned down pain medication from the doctor. If I won't take it from the doctor I'm not doing grey market.
 
m100568 said:
Muscle relaxers, yes. Pain medication, no. Last time I really threw out my back and could barely get in and out of a chair or take a few steps I turned down pain medication from the doctor. If I won't take it from the doctor I'm not doing grey market.
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I mean, it's stronger than fentanyl, I'm sure there's alternative that doesn't instantly kill you if incorrectly dosed
 
It's certainty is a lot more powerful / dangerous than I thought! I assumed it was weaker than oxycodone, and so the major concern was just dosing properly.

From what I just read, demorphin is 30-40 times stronger than morphine, while fentanyl is 50-100 times stronger than morphine. For comparison, oxycodone is about the same strength as morphine.
 
Calm Logic said:
It's certainty is a lot more powerful / dangerous than I thought! I assumed it was weaker than oxycodone, and so the major concern was just dosing properly.

From what I just read, demorphin is 30-40 times stronger than morphine, while fentanyl is 50-100 times stronger than morphine. For comparison, oxycodone is about the same strength as morphine.
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There's no clinical trials on this one, we have no idea how safe or dangerous it really is

It's currently used for horse doping, but nothing for humans because of its drawbacks

I would not play with this, stick with proven ones
 
The more I read about dermorphin, it seems less potentially fatal, but also more worthless.

For the purported purpose of pain relief, the half-life is a joke, at least in small animal studies:


We have previously demonstrated that plasma half-life of dermorphin is 1.3 min, the peptide being rapidly destroyed in kidney and liver to ditri- and tetra N-terminal peptides that are biologically inactive.
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Google Gemini says the half-life is 24 minutes, but most pain relievers have a half-life of at least several hours.
 
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