Dermorphin for pain?

[Calm Logic]

I have read a lot on this and even have a couple of vials in the fridge but have never tried it. The dosing is difficult, not enough and you get no pain releif, too much and you risk overdose. The half life means the relief is only a couple of hours and then you have to dose again, but do you dose lower on the second dose? No idea. It also zeps your opioid receptors and will make normal pain relievers (Oxy, hydrodone) less effective. This one is bad news, and I can't see any reason to even try it.

If you're the YOLO type and insist on trying this at least have some narcan in the house and let someone know what you are doing. There are very few peps in the gray world that come with the risk of instant death, this is one of them.

According to some anecdotal reports on Reddit, the pain relief was zero even when they did get some feelz for a minute. Like it's over before it even started.

The one person I found on Discord who said it was a "game changer" was extremely vauge. Nothing about dosing or any other details. So could have been placebo.

And like you are saying, the ones who took a much higher dose (whatever that is) may have had eternal pain relief, and are not here to report back. It would be more deadly without the short half life.

And some people who try it think it's crazy to go to a pain clinic for carefully prescribed opiods that are later dispensed by a real pharmacist. So go figure.

If one is worried about opioid dependency, one can ask a pain doc for buprenorhpine instead or try non-opiods together like meloxicam, gabapentin, duloxetine, and/or LDN.

 

[808otter]

I have read a lot on this and even have a couple of vials in the fridge but have never tried it. The dosing is difficult, not enough and you get no pain releif, too much and you risk overdose. The half life means the relief is only a couple of hours and then you have to dose again, but do you dose lower on the second dose? No idea. It also zeps your opioid receptors and will make normal pain relievers (Oxy, hydrodone) less effective. This one is bad news, and I can't see any reason to even try it.

If you're the YOLO type and insist on trying this at least have some narcan in the house and let someone know what you are doing. There are very few peps in the gray world that come with the risk of instant death, this is one of them.

Yeah spent quite a while with the dosing instructions and wow not one you want to mess up. Looks like it is made from a poisonous frog venom, death by frog don't sound like the way to go but was curious if anyone had tried. Hope you are finding other ways to get some pain relief.

 

[PickleRN]

As a nurse who treats pain patients all day… complete pain relief is sometimes impossible to achieve. However, if you’re searching out other means to control your pain, then it’s not well controlled. You should seek out treatment with a pain management specialist, orthopedic doctor, or neurosurgeon to treat the underlying problem.

 

[Calm Logic]

Exactly. Like for chronic back pain, pain specialists also do shots, nerve ablation, implanted nerve stimulators, etc. Not to mention physical therapy and alternative treatments like inversion tables from Amazon, massage therapy, and chiropractic care.

At-home cold-therapy machines like with knee or shoulder wraps are pretty awesome for any extremity, including the hands, wrists, and feet. They are usually prescribed after surgery, but they can help anytime to reduce pain and inflammation.

For knee arthritis that doesn't get enough relief fom cortisone shots, the interventional radiology procedure GAE is becoming more known as an alternative to knee replacement. There's also nerve ablation. And neurostimulator implants can even be used for knee pain.

For foot pain, even buying new rocker sneakers every three months or so can help. As can orthotics, night splints, cortisone shots, and surgery.

For hand/finger arthritis, paraffin wax can help, as can thermic gloves, meloxicam, Voltaren gel, and cortisone shots (sometimes after an MRI).

I usually live pain-free, but the average age in my part of Arizona is sometimes 65. So almost everyone has been to an orthopedist at least once. I love and hate orthopedists, mostly the latter. I rather see a pain specialist.

 

[vjorvj5150]

Has anyone ever used Dermorphin, a peptide that I’ve recently read is very good for chronic pain?

Reconstituted 5mg of dermorphin using 2ml of bac water.

I would definitely recommend using 3ml instead.

I was having lower back pains.

So I took 6 units on a 100 unit syringe.

Please don't believe the person who said to take anything above 250 mcg.

Back pain is completely gone but I am higher than f***.
I am extremely happy that I didn't accidentally overdose.
V.

 

[lessthanhalf]

I read up on it when I first saw it was available. I have chronic abdominal pain from ulcerative colitis and thought it might be useful if I was desparate. The most obvious problem is the super short half life of minutes in the blood stream , like a lot of peptides. The effect might not be that short, as, if injected subcutaneously it may not be degraded there as fast, but it is not likely to take more than half an hour to be absorbed and degraded. Injected IV, sounds like a bad idea, highly potent short acting opiate with poorly understood dosing sounds like an excellent way to die of an overdose, and still a risk with s/c injection.
The bigger problem is if it does work for a while, taking short acting strong opiates by injection for pain relief for chronic conditions, sounds like a pretty sure fire path to addiction.
And it is still a strong opiate and would be considered as such by customs if they intercepted it, or at least in Australia, whether it is officially a banned or restricted substance or not., of course they are unlikely to know what it is, or bother to look it up or work it out , but still a bit of a concern.

 

[winiki]

Reconstituted 5mg of dermorphin using 2ml of bac water.

I would definitely recommend using 3ml instead.

I was having lower back pains.

So I took 6 units on a 100 unit syringe.

Please don't believe the person who said to take anything above 250 mcg.

Back pain is completely gone but I am higher than f***.
I am extremely happy that I didn't accidentally overdose.
V.

It sounds like you didnt calculate properly and almost killed yourself, smh. Maybe you Should listen to the person who said avoiding above 250mg. Your measurements above doesnt really give a clear idea of exactly how much you took. Maybe you could clarify your math, method of injection, and applicators. 6/100 units of a 1ml? @ 2.5mg/ml? whats the total mcg you took?

Spinal application is only 20mcg. Consider doing it topically. I got it to research making a patch out of it. It comes from a frog and the natural way The Frog affects you is topically. Research states Dermorphin cannot cross the blood brain barrier so that hijack that by using the spine like they do when they give an epidural during labor. The idea for me is to alleviate pain signals to improve my ability to self soothe during episodes. The lidocaine patches are ok, but I'd like a better alternative.