Diet/Muscle mass retention on reta

[CuriousInquiry]

I'm leaning heavily toward retatrutide for body recomp, given the study results and loads of positive outcomes I've seen. I am, however, still concerned about muscle wasting. I've been spending a lot of time trying to dig into the science behind reta (I at least understand the three mechanisms), and it seems to be superior in muscle mass retention to other GLPs, but I'm having trouble filtering the massive amount of confident anecdotal from the science based.

One of the things I keep seeing people say is that reta is incompatible with very low carb diets to the point of maybe being dangerous (though I've never seen this backed by anything that doesn't sound like bro science). Another is that you've gotta take X or Y peptide along with it or you lose a bunch of muscle even with good protein intake and lifting. I'm not interested in that game.

So, can anyone point me to some solid reta-specific and science based information about diet macros, and good practices to maximize muscle mass retention when losing fat on this drug? Or, failing that, at least some solid anecdotal evidence (long term, consistent, accurate measurements, etc) showing what has worked for you?

 

[woundcarping]

...I've been spending a lot of time trying to dig into the science behind reta...

Almost the same thread was started yesterday.

 

[tubby]

LOL, you're asking a reasonable question, but you're asking it in the wrong way. We don't even have a phase 3 paper available on reta yet. How in the world would we have more advanced studies in regards to affect on muscle? And to the extent we did, it would be from the manufacturer, so designed to show the most favorable result possible. 🤣

I think you'd be better off looking for research on GLPs that have been on the market for years and the evaluating whether those studies would likely be applicable to reta or not.

 

[PAPoots]

Almost the same thread was started yesterday.

View attachment 24713

Thanks for the heads up. I felt like I responded to a similar question recently.

 

[Llanitox]

Ok so some info for you that may help you decide.

Was previously on an anabolic cycle which ended nearly 3 months ago. Naturally I was apprehensive of muscle loss.

I stated Reta in April taking 2mg a week micro dosing 1mg twice a week. I’ve gone from 97kg to now 91kg.

My diet is dialled in at the following

Calories:1800
Carbs:160
Protein:175 (sometimes a lot higher)
Fats:55


I was worried about muscle retention too but I weight train 5 times a week, some mass has been loss but that has been mainly water retention. I can happily say I haven’t lost any strength.

Having creatine will help your muscles look fuller too or something as simple as a refeed day to replenish glycogen levels.

In summary if you some resistance training and eat a high protein diet you’ll be fine.

 

[LabRatts]

I'm leaning heavily toward retatrutide for body recomp, given the study results and loads of positive outcomes I've seen. I am, however, still concerned about muscle wasting. I've been spending a lot of time trying to dig into the science behind reta (I at least understand the three mechanisms), and it seems to be superior in muscle mass retention to other GLPs, but I'm having trouble filtering the massive amount of confident anecdotal from the science based.

One of the things I keep seeing people say is that reta is incompatible with very low carb diets to the point of maybe being dangerous (though I've never seen this backed by anything that doesn't sound like bro science). Another is that you've gotta take X or Y peptide along with it or you lose a bunch of muscle even with good protein intake and lifting. I'm not interested in that game.

So, can anyone point me to some solid reta-specific and science based information about diet macros, and good practices to maximize muscle mass retention when losing fat on this drug? Or, failing that, at least some solid anecdotal evidence (long term, consistent, accurate measurements, etc) showing what has worked for you?

Seek out Josh Holyfield on YouTube, he has a lot of info on just that .
Keep protein HIGH and of course keep/start doing weight bearing exercises.
I’m 59, sw was180 @18 % bf now 160 12% bf, not a pound of muscle lost- one MUST consume a minimum of 1 gram protein per lean target weight and MUST work the muscle you have-
Other research items help in this goal, but you need to do your due diligence for your own situation/condition. For reference 5 years ago I was 250# 36% bf, lost a lot of weight on carnivore and maintained it easily, but peps and more knowledge have “upped my game”.
Godspeed in your endeavors 🙏

 

[Elgordoboy]

Seek out Josh Holyfield on YouTube, he has a lot of info on just that .
Keep protein HIGH and of course keep/start doing weight bearing exercises.
I’m 59, sw was180 @18 % bf now 160 12% bf, not a pound of muscle lost- one MUST consume a minimum of 1 gram protein per lean target weight and MUST work the muscle you have-
Other research items help in this goal, but you need to do your due diligence for your own situation/condition. For reference 5 years ago I was 250# 36% bf, lost a lot of weight on carnivore and maintained it easily, but peps and more knowledge have “upped my game”.
Godspeed in your endeavors 🙏

180 at 18% and 160 at 12% with not a pound of muscle loss equates into 10lbs of lost fat. To what do you attribute the remaining 10lbs of weight loss?

 

[LabRatts]

BBQ sauce, of course.