Dose vs Estimated Level

[cloratheshadow]

What’s your dosing schedule and what is your average peak/low estimated level? I’m just curious what that looks like while I’m currently titrating from 5 to 7.5 and up!

 

[Grogu]

Hmmmm. Understand the question, I do not.

 

[cloratheshadow]

Hmmmm. Understand the question, I do not.

Autocorrected dosing to food lol

What is your dosing schedule and dose (ex. 5 days, 7.5mg) and what do your peaks and valleys look like on an app like Shotsy (ex. 5.5-10)

 

[cloratheshadow]

Hmmmm. Understand the question, I do not.

I just realized the post had several typos. Note to self: don’t post while rushing to work.

 

[msyntakz]

I am dosing Tirz 2.5mg every seven days, been going 5 weeks, so I should be at steady state, which is also reflected in Shotsy. Lowest estimate 1.7 to highest 3.5

I know Tirz has a 5 day half-life but I am stacking with Reta, so it carries me through.

Friday Tirz 2.5mg
Monday Reta 1mg

So far that works well to get me through the weekend when I would have been most likely to overeat and well balanced through the week, between the two peak/valley overlaps.

 

[woundcarping]

I just realized the post had several typos. Note to self: don’t post while rushing to work.

I thought you were drunk or your blood sugar got carried awat😂

8mg Monday evening and Friday morning. Levels depend on how the PK are modeled, but something like 15mg/20mg for me according to Shotsy. Give or take half a mg pretty easily.

 

[Grogu]

Autocorrected dosing to food lol

What is your dosing schedule and dose (ex. 5 days, 7.5mg) and what do your peaks and valleys look like on an app like Shotsy (ex. 5.5-10)

Figured it was something about peak levels and wasn't sure about the food thing 😂.

Although I love looking at the pretty peaks and valleys of drug levels from apps like Shotsy, I just do the plain ol' vanilla dosing of tirzepatide and pin once per week. I've stacked with sema and now cagri and don't track those either. My dose is now 18mg of tirzepatide weekly.

 

[lessthanhalf]

The peaks and dips on apps or glp plotter are mostly useful to get an idea of what drug levels are doing over time, so you can see that peaks are usually about 24h after a dose, and that repeated doses will build up the valleys and peaks over 4 weeks or so, and the real use is to see how that corresponds to side effects. As you can plug in different doses and timings and see what the levels look like, which is useful once you know what side effects happen at what levels. GLP drugs have very different half lives to just about every other drug, so seeing what it looks like on a graph helps to understand what is going on.

But mainly you have to go by feel, it is what matters. If what you are taking is causing side effects, then you need to reduce doses or sometimes split doses instead, and if you are hungry , increase doses. There is so much individual variation in side effects and response to the drugs that your actual effects from them are what matter in the end anyway. The graphs are just an abstraction , a general estimate rather than actual levels, but can be useful to work out doses or timing of doses if you are going to dose more often than once a week.

 

[Grogu]

The peaks and dips on apps or glp plotter are mostly useful to get an idea of what drug levels are doing over time, so you can see that peaks are usually about 24h after a dose, and that repeated doses will build up the valleys and peaks over 4 weeks or so, and the real use is to see how that corresponds to side effects. As you can plug in different doses and timings and see what the levels look like, which is useful once you know what side effects happen at what levels. GLP drugs have very different half lives to just about every other drug, so seeing what it looks like on a graph helps to understand what is going on.

But mainly you have to go by feel, it is what matters. If what you are taking is causing side effects, then you need to reduce doses or sometimes split doses instead, and if you are hungry , increase doses. There is so much individual variation in side effects and response to the drugs that your actual effects from them are what matter in the end anyway. The graphs are just an abstraction , a general estimate rather than actual levels, but can be useful to work out doses or timing of doses if you are going to dose more often than once a week.

Since I've had very few side effects from tirzepatide and the hunger supression has been pretty consistent, the need for graphing levels and different dosing regimes has been pretty much unnecessary. But I'm sure that some people find the graphs helpful for managing symptoms and hunger cues.

 

[woundcarping]

(Reta) Green is 7mg 2x weekly, purple is 12mg 1x weekly, blue is 8mg 2x weekly.

The plots aren’t magical, they’re only as good as the math and assumptions they model. Tmax, bioavailability, half life, and clearance rates are some of the variables that have to be assumed. GLP Plotter doesn’t match Shotsy values which is fine.