Drugs for reta side effects

[diogenes]

On Friday morning I injected 6mg of retatrutide subcutaneously in my thigh. This is up from 4mg the previous week, and 2 mg the week before that.

• I felt nothing on Friday
• My appetite was mildly suppressed on Saturday
• It was more suppressed Sunday and Monday (today), so great

Unfortunately it's been very difficult to sleep, and my skin feels sensitive and even painful all over. I've been wondering what drugs I might take to help with this. I have lying around some propranolol, gabapentin, and clonidine, all of which I've been prescribed for other things but do not currently take. Might any of these help?

 

[lemon lady]

I can't help with the sleeplessness but I've found Zinc and antihistamines help with the skin sensitivity plus moisturise twice a day and avoid actives like vit.C for a while

 

[GLP1Pharmacist]

Have you tried Sema or Tirzepatide?

 

[PackmanJohnny]

Titrating kinda quick, no? Most of the research Ive seen titrates every 4 weeks by 1MG or so, you might just be hitting the receptor too hard too often.

 

[Calm Logic]

I can't help with the sleeplessness but I've found Zinc and antihistamines help with the skin sensitivity plus moisturise twice a day and avoid actives like vit.C for a while

And Benadryl can help with sleep too, as can melatonin, marijuana gummies, and reading the terms of service for every company you deal with. One hack with melatonin is to take a low dose of 1 mg a few hours before bed.

On the prescription side, trazodone is relatively easy to get from some providers. Gabapentin can help with both nerve pain and sleep. So I would keep taking the gabapentin and maybe raise the nightly dose, taking it 2-3 hours before bed.

 

[peptidepower77]

On Friday morning I injected 6mg of retatrutide subcutaneously in my thigh. This is up from 4mg the previous week, and 2 mg the week before that.

• I felt nothing on Friday
• My appetite was mildly suppressed on Saturday
• It was more suppressed Sunday and Monday (today), so great

Unfortunately it's been very difficult to sleep, and my skin feels sensitive and even painful all over. I've been wondering what drugs I might take to help with this. I have lying around some propranolol, gabapentin, and clonidine, all of which I've been prescribed for other things but do not currently take. Might any of these help?

You might want to slow it down. Lots of people start with 1mg or 2mg a week for a month, then double that for the next month.

 

[diogenes]

Have you tried Sema or Tirzepatide?

I tried tirzepatide for a few weeks and switched to reta simply because it seems to offer more rapid weight loss. I am lifting and doing cardio as well, so I figured the quicker weight loss was worth it.

 

[diogenes]

You might want to slow it down. Lots of people start with 1mg or 2mg a week for a month, then double that for the next month.

Hmm ok. Do you think I should do 6mg next week as well and just hold it there for a while? Or step it down to 4 or 5mg?

 

[zpped]

Hmm ok. Do you think I should do 6mg next week as well and just hold it there for a while? Or step it down to 4 or 5mg?

Personally, I'd skip the next dose and then start back at 2mg. You've overdosed on reta and are going to have a bad week. Make sure you keep your fluids and calories up.

 

[peptidepower77]

Hmm ok. Do you think I should do 6mg next week as well and just hold it there for a while? Or step it down to 4 or 5mg?

You have about 8.5mg in your blood right about now, which is what most people don't hit until week 10-12 I think.

I would wait until your next shot and make a decision. If you still don't feel good, you can wait one extra week. By then you'll have about 2mg in your blood and can start again at 2mg for a few weeks, then move up to 4mg.

If you feel good at the end of the week, you could do the 4mg shot, and stay there a month or so. But I wouldn't move past 4mg for a while until your body adjusts.

 

[AndyPanda]

If your side effects are bad enough for you to consider multiple other drugs to control them, you should probably reconsider the original drug. More drugs is not better. This is a can of worms.

 

[zpped]

most people don't hit until week 10-12 I think.

Took me 10 months to reach that dose.

 

[PackmanJohnny]

If your side effects are bad enough for you to consider multiple other drugs to control them, you should probably reconsider the original drug. More drugs is not better. This is a can of worms.

😀 Reminds me of my DNP days smh.

People forget about the part where the stuff you take is supposed to be Performance Enhancing.

 

[thomas_yajirobe]

Were you on any GLP1s prior to this? I was on max dose tirz and I felt nothing on 1mg twice a week and that was last week lol. I bumped it up to one full shot of 4 mg not too long ago. lets see how that plays out.

 

[CrimsonTaco47]

Have you actually researched the titration schedules out there? This is like the 4th post I’ve seen of reckless and dangerous titrations on Reta….these medications can be extremely dangerous if you blow in there so quick. Everyone is different and requires different doses to feel the desired effects but damn. You’re being reckless bro

 

[Calm Logic]

I wonder what words of wisdom @Super Trips would provide 🤔

 

[Super Trips]

Have you actually researched the titration schedules out there? This is like the 4th post I’ve seen of reckless and dangerous titrations on Reta….these medications can be extremely dangerous if you blow in there so quick. Everyone is different and requires different doses to feel the desired effects but damn. You’re being reckless bro

I'm sure you use a toothpaste tube as directed but how can you say something is dangerous if you never had a human actually do it and see for itself.
research is not for everyone but the most brilliant minds ever did self testing
take Alexander Shulgin and Ann Shulgin for example they made the most advanced chemical discoveries of the 20th century.

 

[AndyPanda]

I miss @raw_oyster_eater. He would try anything once.

 

[FlowerFairy]

On Friday morning I injected 6mg of retatrutide subcutaneously in my thigh. This is up from 4mg the previous week, and 2 mg the week before that.

• I felt nothing on Friday
• My appetite was mildly suppressed on Saturday
• It was more suppressed Sunday and Monday (today), so great

Unfortunately it's been very difficult to sleep, and my skin feels sensitive and even painful all over. I've been wondering what drugs I might take to help with this. I have lying around some propranolol, gabapentin, and clonidine, all of which I've been prescribed for other things but do not currently take. Might any of these help?

It takes 4 weeks to feel the full effect of Reta. Going up every 2 weeks is a great way to experience all the side effects. No wonder you can’t sleep. Be glad your heart rate isn’t through the roof too. Slow down and this will go away. Propranolol is a blood pressure medicine- why would you take a beta blocker to help you sleep? Same for clonidine. You take those two together and you might not sleep, but there’s a good chance you’ll faint from low blood pressure. Gabapentin is used for neuropathic pain and seizures; the pathway it works along does not induce sleep. Try Benadryl, and back off on the Reta.

“Hmm ok. Do you think I should do 6mg next week as well and just hold it there for a while? Or step it down to 4 or 5mg?”

Step it down. You have overdosed yourself. Follow the correct titration schedule. You didn’t get fat overnight, you won’t lose it overnight- but you might do permanent damage to your body.

I miss @raw_oyster_eater. He would try anything once.

Seems he sent his replacement. 🙄😒

 

[FlowerFairy]

Have you actually researched the titration schedules out there? This is like the 4th post I’ve seen of reckless and dangerous titrations on Reta….these medications can be extremely dangerous if you blow in there so quick. Everyone is different and requires different doses to feel the desired effects but damn. You’re being reckless bro

Sounds like you’re a newbie with some common sense. Thank you for that. I’m getting really sick of posts like this.

 

[FlowerFairy]

I'm sure you use a toothpaste tube as directed but how can you say something is dangerous if you never had a human actually do it and see for itself.
research is not for everyone but the most brilliant minds ever did self testing
take Alexander Shulgin and Ann Shulgin for example they made the most advanced chemical discoveries of the 20th century.

Except humans HAVE done this before, and gotten sick as heck. This is reckless and not smart.

 

[diogenes]

Have you actually researched the titration schedules out there? This is like the 4th post I’ve seen of reckless and dangerous titrations on Reta….these medications can be extremely dangerous if you blow in there so quick. Everyone is different and requires different doses to feel the desired effects but damn. You’re being reckless bro

I prefer the term "aggressive," but yes I'm aware the phase 2 trials started at much lower doses. I'll give it a rest for a bit and restart more gently.

 

[Calm Logic]

Gabapentin is used for neuropathic pain and seizures; the pathway it works along does not induce sleep.

From a small study:

Gabapentin increases brain concentrations of γ-amino-butyric acid (GABA) and decreases glutamatergic activity...

After at least 4 weeks of abstinence, alcoholic patients with persistent insomnia reported significant sleep improvement during treatment with either gabapentin or trazodone. Although the overall sleep of each medication group improved significantly over time, patients who received gabapentin improved significantly more than did patients who received trazodone. At follow up, gabapentin-treated patients were less likely than trazodone-treated patients to have initial insomnia and to awaken in the morning feeling tired and worn out. Both gabapentin and trazodone were well tolerated as indicated by low dropout rates that did not differ significantly between the two groups. All dropouts occurred after the first dose of medication because of morning drowsiness.

 

[FlowerFairy]

From a small study:

Yes. ALCOHOLICS.

 

[Calm Logic]

Drowsiness is listed as a side effect, so it's not surprising to me that gabapentin can help with sleep, especially since some people discontinue gabapentin due to daytime drowsiness. A meta-analysis.

 

[FlowerFairy]

Drowsiness is listed as a side effect, so it's not surprising to me that gabapentin can help with sleep, especially since some people discontinue gabapentin due to daytime drowsiness. A meta-analysis.

Yes, but a side effect is something that might happen. Additionally you have to consider the end user. This one has already demonstrated that he is lacking in common sense. If he takes one capsule and it doesn’t make him sleepy, by his own logic he should triple the dose. Harm reduction is the goal.

 

[DR.D.]

On Friday morning I injected 6mg of retatrutide subcutaneously in my thigh. This is up from 4mg the previous week, and 2 mg the week before that.

• I felt nothing on Friday
• My appetite was mildly suppressed on Saturday
• It was more suppressed Sunday and Monday (today), so great

Unfortunately it's been very difficult to sleep, and my skin feels sensitive and even painful all over. I've been wondering what drugs I might take to help with this. I have lying around some propranolol, gabapentin, and clonidine, all of which I've been prescribed for other things but do not currently take. Might any of these help?

I take just a 1/4 dose of a cardio selective beta blocker and it seems to help. Same thing if stacking with T3 or T4. Its hard to sleep when your pulse rate is though the roof!

If you like natural, a few Hawthorn Berry capsules can be surprisingly effective as well.

 

[Calm Logic]

I would rely more on marijuana gummies anyway, not to mention the Benadryl.

 

[FlowerFairy]

I would rely more on marijuana gummies anyway, not to mention the Benadryl.

Same. Gabapentin is what I give my 16 yo dog for pain. Benadryl and MJ gummies are more effective for sleep. Mushroom gummies are pretty relaxing too.

 

[PackmanJohnny]

Yes, but a side effect is something that might happen. Additionally you have to consider the end user. This one has already demonstrated that he is lacking in common sense. If he takes one capsule and it doesn’t make him sleepy, by his own logic he should triple the dose. Harm reduction is the goal.

It's not the most popular opinion(especially here), but RESULTS are the goal, harm reduction is and always will be priority 2.

No matter what anyone here or anywhere says, If you're injecting experimental peptides, not even considering they come from the chinese gray market of all fkn places, you're willing to at least risk a LITTLE harm if it will get you the RESULTS you want.

This guy seems like the average newcomer in SSA's Discord(You guys should take a peek in there when bored, some of those idiots are HILARIOUS) who is lacking general understandings of Half-lifes(lives? nah),and probably reta itself. For the love of god hes pinning subq into his THIGH. he probably just needs to fuck himself up a little bit(in a clean and safe ish and reparable way) and he'll learn his lesson and start reading. He's already taken the first step by coming here and opening himself up to verbal abusein exchange for (if hes lucky) some good advice.