Easy reconstitution and dosing spreadsheet

Morbius

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I wanted a different way to view vial options and calculate doses, so I made a spreadsheet. Some of you may be interested in using it too.

While the spreadsheet is large, it only asks you to think about TWO NUMBERS... The amount of product in a vial (in mg) and the amount of bac used (in mL). It calculates everything else for you based on common dosing protocols. If you are doing your own thing, you can customize the doses too.

Please consider this a preview, and if you take a look at the spreadsheet... please help me check my math, and let me know if there are better default dose values to choose.
https://docs.google.com/spreadsheets/d/1wCjjVoozucZX7c4f0feLvKbul1eJSs90sMw2ahCrZNg/edit?usp=sharing

It works like this...

The left side has a list of vials with amounts (in mg) that will look familiar to anyone who has looked at a peppy price list.

The left side also allows you to fill in some amount of bacteriostatic water that you'd use to reconstitute that vial. 2 mL is prefilled.

You then select a product from the drop-down menu below the table. The spreadsheet looks up the typical doses for that product. For example, for sema, it fetches 0.25 mg, 0.5 mg, 1.0 mg, and 2.4 mg as the four dose tiers. Currently, only reta, sema, and tirz are supported. However, you can edit the values and I provided a Custom product so you can put in your own dosing tiers for anything -- up to 6 tiers, in fact.

Then, for each vial, it calculates how much you'd need to draw to get that dose. It shows those values in mL and in units. It will also calculate how many doses per vial, and vials that don't make a single dose or any doses that are too big or small for normal insulin syringes get marked in red.

Obviously, not all of the values are realistic. No one is buying sema in 0.25 mg vials, nor 1000 mg vials. So... Just ignore those rows. If you only care about a few rows like 5-10-20 mg, select the ones you don't care about, right-click, and Hide them. (You can also edit the values in Column A freely if you really want to.)
Lastly, the orange shading shows you if that dose needs a 30, 50, or 100 unit syringe.

Example: Say we are just starting sema at the first tier, 0.25 mg. We have a 2 mg vial, to which we add 2 mL BAC. Row 7 shows that we need 0.25 mL or 25 units, that it should fit in a 30U (or greater) syringe, and that our vial is good for 8 doses. If we had some nonstandard vial, we would just type the amount (in mg) into cell A2, put the BAC (in mL) into B2, and get our report that way.


1740529623315.png


The tab where dosing tiers is defined looks like this. You can customize the values if you wish.

1740531393185.png


That's it!
 
I wanted a different way to view vial options and calculate doses, so I made a spreadsheet. Some of you may be interested in using it too.

While the spreadsheet is large, it only asks you to think about TWO NUMBERS... The amount of product in a vial (in mg) and the amount of bac used (in mL). It calculates everything else for you based on common dosing protocols. If you are doing your own thing, you can customize the doses too.

Please consider this a preview, and if you take a look at the spreadsheet... please help me check my math, and let me know if there are better default dose values to choose.
https://docs.google.com/spreadsheets/d/1wCjjVoozucZX7c4f0feLvKbul1eJSs90sMw2ahCrZNg/edit?usp=sharing

It works like this...

The left side has a list of vials with amounts (in mg) that will look familiar to anyone who has looked at a peppy price list.

The left side also allows you to fill in some amount of bacteriostatic water that you'd use to reconstitute that vial. 2 mL is prefilled.

You then select a product from the drop-down menu below the table. The spreadsheet looks up the typical doses for that product. For example, for sema, it fetches 0.25 mg, 0.5 mg, 1.0 mg, and 2.4 mg as the four dose tiers. Currently, only reta, sema, and tirz are supported. However, you can edit the values and I provided a Custom product so you can put in your own dosing tiers for anything -- up to 6 tiers, in fact.

Then, for each vial, it calculates how much you'd need to draw to get that dose. It shows those values in mL and in units. It will also calculate how many doses per vial, and vials that don't make a single dose or any doses that are too big or small for normal insulin syringes get marked in red.

Obviously, not all of the values are realistic. No one is buying sema in 0.25 mg vials, nor 1000 mg vials. So... Just ignore those rows. If you only care about a few rows like 5-10-20 mg, select the ones you don't care about, right-click, and Hide them. (You can also edit the values in Column A freely if you really want to.)
Lastly, the orange shading shows you if that dose needs a 30, 50, or 100 unit syringe.

Example: Say we are just starting sema at the first tier, 0.25 mg. We have a 2 mg vial, to which we add 2 mL BAC. Row 7 shows that we need 0.25 mL or 25 units, that it should fit in a 30U (or greater) syringe, and that our vial is good for 8 doses. If we had some nonstandard vial, we would just type the amount (in mg) into cell A2, put the BAC (in mL) into B2, and get our report that way.


View attachment 5719

The tab where dosing tiers is defined looks like this. You can customize the values if you wish.

View attachment 5720

That's it!
Yeah but did you get my taxes done? /s
 
Down the road I may set it so that visitors can edit the file, but I'd then have to protect almost every cell other than the few places you are supposed to customize. It would be a different kind of PITA for everyone.
 
Can someone verify Reta dosing is on par with Tirz?
Are you asking if reta has the same dosing schedule as tirz?

From what I have seen, with retatrutide you begin with 2mg/wk for at least 4 weeks, then 4mg/wk per 4 weeks, to 6mg/wk per 4 weeks, then 8mg/wk for 4 weeks, etc. I do not recall what dose is the recommended upper limit. I have seen it top out at 8mg, but have also read of others dosing up to 12mg/wk.

Of course, you do not need to move up each month, nor does one have to jump in 2mg increments. I wouldn't do bigger jumps, but smaller is always okay. Caution is your friend in this realm.

So no, not on par with tirzepatide, but a similar titration schedule (in terms of moving up each month).

Hope that helps a little.
 
Are you asking if reta has the same dosing schedule as tirz?

From what I have seen, with retatrutide you begin with 2mg/wk for at least 4 weeks, then 4mg/wk per 4 weeks, to 6mg/wk per 4 weeks, then 8mg/wk for 4 weeks, etc. I do not recall what dose is the recommended upper limit. I have seen it top out at 8mg, but have also read of others dosing up to 12mg/wk.

Of course, you do not need to move up each month, nor does one have to jump in 2mg increments. I wouldn't do bigger jumps, but smaller is always okay. Caution is your friend in this realm.

So no, not on par with tirzepatide, but a similar titration schedule (in terms of moving up each month).

Hope that helps a little.
Thanks for that. I was specifically referring to this dosing schedule worksheet. It has Reta starting out at .5, .1, 1.5 etc. My research had Reta at starting doses the same as Tirz which was 2mg for me. I've always moved up .5mg a time with Tirz, which never got above 3mg for me. I dopped back down to 2mg for maintenance. I recently started dosing 1mg/1mg Tirz/Reta.
 
Thanks for that. I was specifically referring to this dosing schedule worksheet. It has Reta starting out at .5, .1, 1.5 etc. My research had Reta at starting doses the same as Tirz which was 2mg for me. I've always moved up .5mg a time with Tirz, which never got above 3mg for me. I dopped back down to 2mg for maintenance. I recently started dosing 1mg/1mg Tirz/Reta.
Sorry for misunderstanding! It's early in the morning for me, lol. Congrats on reaching maintenance! :)
 
It has Reta starting out at .5, .1, 1.5 etc. My research had Reta at starting doses the same as Tirz which was 2mg for me.
When I looked into reta dosing I had a hard time finding a consensus as with sema. If there is a less wrong set of numbers I can use I am happy to update it.
 
When I looked into reta dosing I had a hard time finding a consensus as with sema. If there is a less wrong set of numbers I can use I am happy to update it.
The closet thing to a consensus that I could find on reta was to start using the dosing scheduled being used for the stage 3 trial. That involves using 2 mg each week for 4 weeks; then moving up to 4mg each week for 4 weeks. I don't remember the amounts for subsequent jumps, but I believe they're 2 or 3 mgs every 4 weeks.
 
Cooll, thanks. I updated it to 2-4-6-8-10-12 for reta. It's easy to change if needed. (And everyone can put their own custom dosing tiers in anyway.)

1740599274205.png
 

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