Eli Lilly plans on seeking FDA approval for weight loss pills before the end of this year; results of phase 3 trial

[keangkong]

Pill Causes Major Weight Loss in Eli Lilly Trial’s Results: The company said it planned to seek Food and Drug Administration approval for the drug, orforglipron, before the end of the year. Here is a link to a New York Times article on the subject. There is no paywall:​

https://www.nytimes.com/2025/08/07/health/obesity-pill-eli-lilly.html?unlocked_article_code=1.cU8.0ZE_.OkbPmccYcUDX&smid=url-share

It appears the drug will be quite effective yet less effective than tirzepatide. The drug should be much easier to produce in quantity that the GLP-1 drugs. One person in the article suggests it could be much cheaper than existing drugs; I doubt that will end up happening. I suspect many folks who wouldn’t consider injecting themselves will use it.

 

[esdsafepoet]

I feel like they missed an opportunity to name it orforglipr0n

 

[AndyPanda]

I don’t trust this. Semaglutide and Tirzepatide are SO effective that it makes no sense to introduce a new drug, unless they are attempting to make it seem more desirable than the injectable drugs that are easy to reproduce by UGLs and sell on the gray market. “If it is not broken” and all of that.

 

[keangkong]

I don’t trust this. Semaglutide and Tirzepatide are SO effective that it makes no sense to introduce a new drug, unless they are attempting to make it seem more desirable than the injectable drugs that are easy to reproduce by UGLs and sell on the gray market. “If it is not broken” and all of that.

It's not a matter of trust. They know that many folks will refuse to inject themselves because they hate needles. I agree that the smart move is to stick with injectables even after this new one gets approved.

 

[FrankTdog]

I would rather take a weekly shot than a pill daily. Especially since it has to be taken on an empty stomach in the morning with a 30 minute wait for food or beverage. That's way too long to wait for coffee.