Endotoxin Warning

[rodrom82]

I'm glad you brought this up too. I've been doing peps for more than 3 years - endotoxin testing is the new hype. 3 years ago, 2 years ago - it was rare for anyone to complain of sickness from peptides - from endotoxins. No Chinese vendor guarantees that will pass, and with the math calculation endos for 1 person could be nothing but for another could be something that leads to what exactly? An injection site reaction... There is no huge illness going around for endos in peptides... I guess maybe not yet one could say. Could also be another way for labs to make more money when the worst that could happen is an ISR. Peps been around for a long time... just now getting mainstream.

what about testing for heavy metals?

 

[HARLEYV2]

I think getting the wrong peptide is the most legitimate fear in the peptide world. The chances of getting enough bacterial contamination to actually get an infection are rock bottom. High endos, I'm not really scared of that. But getting swapped peps, that could actually happen.

I agree with your logic here.

 

[RetCurious]

what about testing for heavy metals?

Never been found, I'd file that under "not an issue" at this point.

 

[Calm Logic]

View attachment 29044
So we have a new record holder with this SPB Epitalon at 4990 eu/vial, right? 🏆

So is vendor/API quality generally worse than before? Or is endo testing just more common?

I have seen COAs in Chinese, including with endo testing. If those were legit, then there are vendors/manufacturers in China that do their own endo testing in China before shipping out.

 

[5byfive]

It seems like endo in a new thing. Peter at Jano has said they have been testing endos for a long time and never seen a fail until recently. Does that mean quality is getting worse? It depends on what you mean by quality. Peter has also said that purity has gotten better over time and, from what I have been seeing, it does not seem that purity has declined recently. My guess would be that the API manufactures have been able to increase their volume without any issues but further down the supply chain, things things may be slipping a bit.

 

[BNLFL]

So is vendor/API quality generally worse than before? Or is endo testing just more common?

I have seen COAs in Chinese, including with endo testing. If those were legit, then there are vendors/manufacturers in China that do their own endo testing in China before shipping out.

Something is missing...

 

[mushroomcow]

The 1360EU is an estimate. The actual result could be wildly different.
The confirmed result is 2306EU. In a 30mg vial.
5EU/kg/hr puts the maximum EU for threshold at 350EU per dose in a 70kg person, 500EU in a 100kg person.
As the maximum dose of tirz is 15mg, that is what should be used to determine is a vial is a fail.
2306eu/vial = 1153eu/15mg dose... 3.3x the maximum for an average 70kg person.

Oh my god