Endotoxins (would you inject and if so any modifications)

[Grogu]

I'm in a third-party independent test group and one of the vial we tested came back with about 78EUs of endotoxins on a T60 batch. Much higher than recent results for the vendor and definitely increasing over time. The vials are testing at about 69mg of tirzepatide. So about 1.13 EUs of endos per mg. And if I'm taking 17mg, then I think I would be receiving about 19EUs of endos per injection.

I've done some research and I think that the FDA says no more than 5EUs of endos per kg of body weight per hour. So, just say I weigh about 110kg then my body could theoretically process 550EUs of endotoxins per hour. So, the 19EUs would seem like a very tolerable limit. Definitely higher than I would have liked to see on the test result, but nothing life threatening (I hope).

I'm wondering if I've done my calculations correctly. And what I'm thinking is that maybe for the first couple of injections out of this batch maybe I'll do a smaller doses and supplement with some other supply to get to the 17mg. I'm also thinking that rather than using this batch until it's done, maybe I would switch between this batch with higher endos and another batch. So, I'm not consistently giving my body these endotoxins weekly. Any other thoughts? I'm also thinking that even with third party testing not everyone is testing for endotoxins, so people are probably going to inject this batch without even knowing about the elevated endos.

 

[Airborne Daddy]

I'm in a third-party independent test group and one of the vial we tested came back with about 78EUs of endotoxins on a T60 batch. Much higher than recent results for the vendor and definitely increasing over time. The vials are testing at about 69mg of tirzepatide. So about 1.13 EUs of endos per mg. And if I'm taking 17mg, then I think I would be receiving about 19EUs of endos per injection.

I've done some research and I think that the FDA says no more than 5EUs of endos per kg of body weight per hour. So, just say I weigh about 110kg then my body could theoretically process 550EUs of endotoxins per hour. So, the 19EUs would seem like a very tolerable limit. Definitely higher than I would have liked to see on the test result, but nothing life threatening (I hope).

I'm wondering if I've done my calculations correctly. And what I'm thinking is that maybe for the first couple of injections out of this batch maybe I'll do a smaller doses and supplement with some other supply to get to the 17mg. I'm also thinking that rather than using this batch until it's done, maybe I would switch between this batch with higher endos and another batch. So, I'm not consistently giving my body these endotoxins weekly. Any other thoughts? I'm also thinking that even with third party testing not everyone is testing for endotoxins, so people are probably going to inject this batch without even knowing about the elevated endos.

I was running figures as well and came up with the same. I'd pin it once and see.what happens. I don't understand the per hour, does that mean the every hour it's in ur blood or how much is ingested every hour..... STG has a bunch of stuff on endotoxins but of course I can't find it now as I'm making chili and drinking a Sam Adams.

 

[Grogu]

I was running figures as well and came up with the same. I'd pin it once and see.what happens. I don't understand the per hour, does that mean the every hour it's in ur blood or how much is ingested every hour..... STG has a bunch of stuff on endotoxins but of course I can't find it now as I'm making chili and drinking a Sam Adams.

I wish I was making chili and enjoying a drink!

My research so far suggests that the 5EUs of endos is per hour per kg of body weight, because it appears that endos clear our bodies pretty quickly, mainly through the liver. I think that the main concern is the sudden spike of endos all at once and the more immune response generated. [ETA: thinking of it, maybe vaccines are filled with a lot of endos and that's why they sometimes want people to hang around for awhile to make sure there is no reaction 😂].

The thing for me is that the FDA's limit is the upper bound and not necessarily what clincians would deem acceptable. I'm sure in the real world some people may experience possible symptoms at way less EUs than the guidance.

 

[Calm Logic]

Some very conservative thoughts from someone else:

Thoughts on Endotoxin test results

tinyurl.com

I set a conservative personal safety limit at 14 EU for the endotoxin load I inject into my body at any one time. This is more than an order of magnitude lower than the clinical limit and equal to the spinal injection limit.

Not all endotoxins are equally harmful and we don't know what types of endotoxins we are getting in these peptides and if they are more or less harmful than average.

If you do have a peptide or group of peptides that test a bit higher in EU, you can minimize endotoxin effects by spreading out your dose over several hours to give your body time to clear the endotoxins.

 

[Calm Logic]

I wish I was making chili and enjoying a drink!

Margaritas are half off on Thursdays here, but I still drink water instead. Maybe not next time 🙂

I asked Gemini about it since the advice keeps changing, and it seems fine now-and-then:

Even one drink triggers a minor "emergency response" where the liver must stop other tasks (like burning fat) to clear the toxin.

The damage from alcohol is cumulative. Regular consumption—even just a few drinks a week—can lead to fatty liver, inflammation, and eventually scarring (cirrhosis)."

A gummy is better though (liver-wise, not taste-wise, haha):

 

[ambot88]

I'd risk it but my risk tolerance is pretty high. I like your idea of alternating with less toxic batches.

 

[Grogu]

I'd risk it but my risk tolerance is pretty high. I like your idea of alternating with less toxic batches.

I just had a thought.... What if I reconstituted a vial of the endotoxic brew with 2mL of bac and reconstituted another vial (non-toxic) with another 2mL and then filtered them both into a sterile vial. Then I would have halfed the endos and only need one shot. Although I don't mind two shots. 🤔

 

[Calm Logic]

Another option, of course, is to spread out the dose into two or more doses, at least by a few hours. So if we want to obsess about endotoxins, we should split all doses, at least when there are no endotoxin results available. Another question would be intra-batch variability with endotoxins.

 

[ambot88]

I just had a thought.... What if I reconstituted a vial of the endotoxic brew with 2mL of bac and reconstituted another vial (non-toxic) with another 2mL and then filtered them both into a sterile vial. Then I would have halfed the endos and only need one shot. Although I don't mind two shots. 🤔

this feels like science.

 

[Airborne Daddy]

I wish I was making chili and enjoying a drink!

My research so far suggests that the 5EUs of endos is per hour per kg of body weight, because it appears that endos clear our bodies pretty quickly, mainly through the liver. I think that the main concern is the sudden spike of endos all at once and the more immune response generated. [ETA: thinking of it, maybe vaccines are filled with a lot of endos and that's why they sometimes want people to hang around for awhile to make sure there is no reaction 😂].

The thing for me is that the FDA's limit is the upper bound and not necessarily what clincians would deem acceptable. I'm sure in the real world some people may experience possible symptoms at way less EUs than the

this feels like science.

At this point pin it.....someone needs to message jano and we'll know. Like toss it or you get double that on a slice of cheese.

 

[mraajr]

Overfill and endotoxins? Can't imagine who that might be.

 

[Airborne Daddy]

Margaritas are half off on Thursdays here, but I still drink water instead. Maybe not next time 🙂

I asked Gemini about it since the advice keeps changing, and it seems fine now-and-then:



A gummy is better though (liver-wise, not taste-wise, haha):

Love weed. I'm federally regulated so that'll be another 30 years until i can do 2 hits instead of 5 drinks.... I have to be ready for follicle testing every day. 18 years in Customs Enforcement turned me into a drinker.... nah I'm a local truck driver.

 

[Airborne Daddy]

Overfill and endotoxins? Can't imagine who that might be.

Primal?

 

[mraajr]

Primal?

By the look of my hs-CRP, almost certainly Primal too 🤣

 

[Airborne Daddy]

By the look of my hs-CRP, almost certainly Primal too 🤣

I have primal test c, tren e, and Mast p....just waiting for June....thought I recognized your avatar Sir...

 

[CNCCurrency]

Pretty sure touching a door knob has way more

Someone mentioned that....if ur liver focuses on dealing with alcohol... glut, tb500, tesa, kisseptin won't work due to livers inability to multi task unlike us..... disappointed to say the least. Must be some way to booze and not take 12 years off ur life. Perhaps if I inject gray goose....jk (but when I was 12 I watched a junkie pin vodka cuz he had nothing else)

I think morning injections would solve that. With short half life in minutes on most of these pep's. Unless you start drinking in the morning.

 

[Airborne Daddy]

Pretty sure touching a door knob has way more

I think morning injections would solve that. With short half life in minutes on most of these pep's. Unless you start drinking in the morning.

Good call thanks....