Extreme Fatigue on Reta

[senglish510]

Anyone else experiencing extreme fatigue on Reta?

I have been on Reta for about 4 months and have been at 5mg for about 6 weeks. I am tired all the time. I can get 8 hours of sleep at night, and I still need a 3 hour nap (on the weekends). I am almost falling asleep at work. I can't stand it!

Are there any peptides that can combat the fatigue?

 

[Calm Logic]

Are you getting enough calories/carbs? Just eating more bread has helped me (in the past with tirz fatigue to some degree). Another common suggestion is electrolytes, such as from electrolyte drinks, food sources, or even protein drinks to some degree.

 

[Builderman]

What’s your daily calorie count? You’re probably way low.

 

[Calm Logic]

In addition to more calories, splitting the dose to twice a week may help with sides/fatigue.

Adding on additional peptides is an option, but hormone therapy of some sort is more likely to be effective, IMHO. Even if it's just taking an oral supplement like boron to boost free testosterone.

Increasing activity/movement here and there is also going to help with mitigating GLP-related brain fog/fatigue. Anything like that is usually a "baby steps" situation.

 

[sheilarae74]

My fatigue was brutal until about 3mg. I felt like I had narcolepsy sometimes. Eventually it went away. It sounds like maybe you titrated up too fast. Getting enough protein during the day helps. I take NR and methylene blue in the morning and that has helped me not to get any afternoon crashes.

 

[lessthanhalf]

Anyone else experiencing extreme fatigue on Reta?

I have been on Reta for about 4 months and have been at 5mg for about 6 weeks. I am tired all the time. I can get 8 hours of sleep at night, and I still need a 3 hour nap (on the weekends). I am almost falling asleep at work. I can't stand it!

Are there any peptides that can combat the fatigue?

Age? Start weight? How much weight have you lost? Side effects of reta ? How hungry are you? How many calories per day? General health? Any chance it is unrelated to reta? Maybe a general medical checkup and basic blood tests?

Extreme fatigue with not much other side effects is not very common but definitely not impossible from reta. Weight loss itself or the effects of longer term low calorie intake can cause fatigue as well. Pretty unlikely to be diabetes if you are on reta, but possibly should be excluded anyway, as well as anaemia and iron deficiency.

Depending on hunger levels , dropping the dose is a easy first step to see if it helps, and it might be worth considering trying to swap to tirz instead, though overall on this forum more people have complained about fatigue from tirz that improved with reta instead, but side effects can be very unpredictable and individual. Or there is lower dose eloralintide, which has high odds of fatigue at higher doses but low at doses under 3mg.

 

[Calm Logic]

Some possible mechanisms with reta fatigue (per Gemini), which tend to resolve over time except for the calorie issue:

While Sema and Tirz force a metabolic shift passively through starvation/caloric deficit, Retatrutide actively and chemically forces the liver to burn fat and increase energy expenditure.

 

[ColdSmoke]

Peptide to help with the side effects of other peptides is a slippery slope I would imagine. I’m going through a bit of the same at 11.5mg tirz. I’m confident my body will settle in once Im on my max dose (I hope I’m there now) for a few months.

 

[eidos]

Since the start of Reta, I've switched to polyphasic sleep. I've gotten used to "naps." My work is mostly asynchronous. I just have to coordinate my video calls a little differently. It doesn't really affect me that much.

I realized that much of my fatigue wasn't related to sleep. I have type 2 diabetes, and with the significant drop in my blood sugar, I took a therapeutic break by stopping metformin. It turned out that the metformin was causing my morning fatigue (lactic acid).

I've done several cycles of SS-31, MOTS-C, and 5-amino-1-MQ, and I've switched from B3 (niacin) to NR (which seems to suit me better).
They significantly reduce fatigue but do not affect the need for sleep.

I've significantly increased my coffee intake (from 1 kg/40 days to 1 kg/30 days). But I'm a fast caffeine metabolizer, so it doesn't interfere with my sleep, just makes me feel more refreshed after naps.
I haven't desired tea since the Reta, so I don't know. But it might be worth a try.