This is a helpful thread for me. I've been microdosing Reta (2.5 mgs every 4 days) since March, added 1mg Tesa daily a couple of weeks ago and Glow 5 times a week. I shed weight really quickly losing 30 lbs in three months, continued resistance training 3 times a week, and seemed to have inexhaustible stores of energy and motivation... until about a week ago when both began to plummet. Ugh. Now I seem to drag myself around and feel far less motivation to be productive, and feel a certain brain fog. And constipation! Fortunately, I don't think anhedonia is the issue cuz libido is intact (thanks be to gawd). Some of the advice above suggests the calorie deficit and lack of hydration may be the cause of fatigue which makes sense so I'll turn my attention to those factors, and perhaps add some carbs and fibre. Are there other suggestions from our GLP1forum hive-mind? Is there a peptide solution as well? I was really enjoying my period of high energy and motivation and would like them to climb back up again! TIA everyone.